OR2A2_HUMAN
ID OR2A2_HUMAN Reviewed; 318 AA.
AC Q6IF42; B2RN85; Q8NGT6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 2A2;
DE AltName: Full=Olfactory receptor 2A17;
DE AltName: Full=Olfactory receptor OR7-11;
GN Name=OR2A2; Synonyms=OR2A17P, OR2A2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-280.
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A2";
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DR EMBL; AB065695; BAC05918.1; -; Genomic_DNA.
DR EMBL; AC091768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136742; AAI36743.1; -; mRNA.
DR EMBL; BK004420; DAA04818.1; -; Genomic_DNA.
DR CCDS; CCDS43671.1; -.
DR RefSeq; NP_001005480.2; NM_001005480.2.
DR AlphaFoldDB; Q6IF42; -.
DR SMR; Q6IF42; -.
DR BioGRID; 138235; 5.
DR STRING; 9606.ENSP00000386209; -.
DR GlyGen; Q6IF42; 1 site.
DR iPTMnet; Q6IF42; -.
DR PhosphoSitePlus; Q6IF42; -.
DR BioMuta; OR2A2; -.
DR DMDM; 84029381; -.
DR MassIVE; Q6IF42; -.
DR PaxDb; Q6IF42; -.
DR PeptideAtlas; Q6IF42; -.
DR PRIDE; Q6IF42; -.
DR Antibodypedia; 32705; 21 antibodies from 15 providers.
DR DNASU; 442361; -.
DR Ensembl; ENST00000408979.3; ENSP00000386209.2; ENSG00000221989.3.
DR GeneID; 442361; -.
DR KEGG; hsa:442361; -.
DR MANE-Select; ENST00000408979.3; ENSP00000386209.2; NM_001005480.2; NP_001005480.2.
DR UCSC; uc011ktz.3; human.
DR CTD; 442361; -.
DR GeneCards; OR2A2; -.
DR HGNC; HGNC:8230; OR2A2.
DR HPA; ENSG00000221989; Not detected.
DR neXtProt; NX_Q6IF42; -.
DR VEuPathDB; HostDB:ENSG00000221989; -.
DR eggNOG; ENOG502T1JY; Eukaryota.
DR GeneTree; ENSGT00940000153255; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q6IF42; -.
DR OMA; RSMRTVY; -.
DR OrthoDB; 1018653at2759; -.
DR PhylomeDB; Q6IF42; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q6IF42; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 442361; 7 hits in 633 CRISPR screens.
DR GeneWiki; OR2A2; -.
DR GenomeRNAi; 442361; -.
DR Pharos; Q6IF42; Tdark.
DR PRO; PR:Q6IF42; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6IF42; protein.
DR Bgee; ENSG00000221989; Expressed in calcaneal tendon and 3 other tissues.
DR ExpressionAtlas; Q6IF42; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR030782; OR2A2.
DR PANTHER; PTHR26453:SF598; PTHR26453:SF598; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 2A2"
FT /id="PRO_0000150453"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 5
FT /note="Q -> K (in dbSNP:rs10230228)"
FT /id="VAR_059982"
FT VARIANT 210
FT /note="L -> P (in dbSNP:rs10252253)"
FT /id="VAR_053128"
FT VARIANT 280
FT /note="F -> L (in dbSNP:rs2961149)"
FT /evidence="ECO:0000269|PubMed:12853948"
FT /id="VAR_059983"
SQ SEQUENCE 318 AA; 35820 MW; CCF412640B5AD8DC CRC64;
MEGNQTWITD ITLLGFQVGP ALAILLCGLF SVFYTLTLLG NGVIFGIICL DSKLHTPMYF
FLSHLAIIDM SYASNNVPKM LANLMNQKRT ISFVPCIMQT FLYLAFAVTE CLILVVMSYD
RYVAICHPFQ YTVIMSWRVC TILVLTSWSC GFALSLVHEI LLLRLPFCGP RDVNHLFCEI
LSVLKLACAD TWVNQVVIFA TCVFVLVGPL SLILVSYMHI LGAILKIQTK EGRIKAFSTC
SSHLCVVGLF FGIAMVVYMV PDSNQREEQE KMLSLFHSVF NPMLNPLIYS LRNAQLKGAL
HRALQRKRSM RTVYGLCL
