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OR2A5_HUMAN
ID   OR2A5_HUMAN             Reviewed;         311 AA.
AC   Q96R48; B9EGX2; O43885; O43888;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Olfactory receptor 2A5;
DE   AltName: Full=Olfactory receptor 2A26;
DE   AltName: Full=Olfactory receptor 2A8;
DE   AltName: Full=Olfactory receptor 7-138/7-141;
DE            Short=OR7-138;
DE            Short=OR7-141;
GN   Name=OR2A5; Synonyms=OR2A26, OR2A8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
RX   PubMed=9500546; DOI=10.1038/ng0398-243;
RA   Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA   Demaille J.G., Giorgi D.;
RT   "Distribution of olfactory receptor genes in the human genome.";
RL   Nat. Genet. 18:243-250(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A5";
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DR   EMBL; AC091768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC136860; AAI36861.1; -; mRNA.
DR   EMBL; U86278; AAC39630.1; -; Genomic_DNA.
DR   EMBL; U86281; AAC39633.1; -; Genomic_DNA.
DR   EMBL; AF399595; AAK95080.1; -; Genomic_DNA.
DR   CCDS; CCDS43668.1; -.
DR   RefSeq; NP_036497.1; NM_012365.1.
DR   AlphaFoldDB; Q96R48; -.
DR   SMR; Q96R48; -.
DR   STRING; 9606.ENSP00000386208; -.
DR   GlyGen; Q96R48; 1 site.
DR   iPTMnet; Q96R48; -.
DR   PhosphoSitePlus; Q96R48; -.
DR   BioMuta; OR2A5; -.
DR   DMDM; 85692724; -.
DR   MassIVE; Q96R48; -.
DR   PaxDb; Q96R48; -.
DR   PeptideAtlas; Q96R48; -.
DR   PRIDE; Q96R48; -.
DR   Antibodypedia; 32700; 79 antibodies from 19 providers.
DR   DNASU; 393046; -.
DR   Ensembl; ENST00000641693.1; ENSP00000493295.1; ENSG00000221836.4.
DR   Ensembl; ENST00000644547.1; ENSP00000494865.1; ENSG00000284896.1.
DR   Ensembl; ENST00000645588.1; ENSP00000496685.1; ENSG00000284896.1.
DR   GeneID; 393046; -.
DR   KEGG; hsa:393046; -.
DR   MANE-Select; ENST00000641693.1; ENSP00000493295.1; NM_012365.2; NP_036497.1.
DR   UCSC; uc011ktw.3; human.
DR   CTD; 393046; -.
DR   DisGeNET; 393046; -.
DR   GeneCards; OR2A5; -.
DR   HGNC; HGNC:8232; OR2A5.
DR   HPA; ENSG00000221836; Not detected.
DR   neXtProt; NX_Q96R48; -.
DR   OpenTargets; ENSG00000221836; -.
DR   PharmGKB; PA32118; -.
DR   VEuPathDB; HostDB:ENSG00000221836; -.
DR   eggNOG; ENOG502SIA2; Eukaryota.
DR   GeneTree; ENSGT00940000153255; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q96R48; -.
DR   OMA; VLWKERS; -.
DR   OrthoDB; 1018653at2759; -.
DR   PhylomeDB; Q96R48; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q96R48; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 393046; 10 hits in 653 CRISPR screens.
DR   GeneWiki; OR2A5; -.
DR   GenomeRNAi; 393046; -.
DR   Pharos; Q96R48; Tdark.
DR   PRO; PR:Q96R48; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q96R48; protein.
DR   Bgee; ENSG00000221836; Expressed in mucosa of stomach and 78 other tissues.
DR   ExpressionAtlas; Q96R48; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..311
FT                   /note="Olfactory receptor 2A5"
FT                   /id="PRO_0000150455"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         126
FT                   /note="I -> V (in dbSNP:rs2961144)"
FT                   /id="VAR_053129"
FT   VARIANT         202
FT                   /note="A -> S (in dbSNP:rs6464573)"
FT                   /id="VAR_053130"
FT   VARIANT         255
FT                   /note="A -> T (in dbSNP:rs6464574)"
FT                   /id="VAR_059984"
FT   CONFLICT        76
FT                   /note="N -> K (in Ref. 3; AAC39633 and 4; AAK95080)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        227
FT                   /note="R -> G (in Ref. 3; AAC39630 and 4; AAK95080)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   311 AA;  35207 MW;  0E515A53AEF1A950 CRC64;
     MTKNQTWVTE FILLGFPLSL RIQMLLSGLF SLLYVFTLLG NGAILGLIWL DSRLHTPMYF
     FLSHLAIIDI SYASNNVPKM LTNLGLNKRK TISFVPCTMQ TFLYMAFAHT ECLILVMMSY
     DRYMAICHPL QYSVIMRWGV CTVLAVTSWA CGSLLALVHV VLILRLPFCG PHEINHFFCE
     ILSVLKLACA DTWLNQVVIF AASVFILVGP LCLVLVSYSR ILAAILRIQS GEGRRKAFST
     CSSHLCMVGL FFGSAIVMYM APKSRHPEEQ QKVLSLFYSL FNPMLNPLIY SLRNAEVKGA
     LKRVLWKQRS K
 
 
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