ASA1_PICGU
ID ASA1_PICGU Reviewed; 449 AA.
AC A5DR04;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=ASTRA-associated protein 1;
GN Name=ASA1; ORFNames=PGUG_05705;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC remodeling. {ECO:0000250}.
CC -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
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DR EMBL; CH408162; EDK41607.2; -; Genomic_DNA.
DR RefSeq; XP_001481942.1; XM_001481892.1.
DR AlphaFoldDB; A5DR04; -.
DR STRING; 4929.XP_001481942.1; -.
DR EnsemblFungi; EDK41607; EDK41607; PGUG_05705.
DR GeneID; 5123791; -.
DR KEGG; pgu:PGUG_05705; -.
DR VEuPathDB; FungiDB:PGUG_05705; -.
DR eggNOG; KOG0322; Eukaryota.
DR HOGENOM; CLU_045414_0_0_1; -.
DR InParanoid; A5DR04; -.
DR OMA; LVCCNTQ; -.
DR OrthoDB; 1543596at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..449
FT /note="ASTRA-associated protein 1"
FT /id="PRO_0000402217"
FT REPEAT 11..54
FT /note="WD 1"
FT REPEAT 57..95
FT /note="WD 2"
FT REPEAT 113..157
FT /note="WD 3"
FT REPEAT 224..263
FT /note="WD 4"
FT REPEAT 273..309
FT /note="WD 5"
FT REPEAT 313..350
FT /note="WD 6"
FT REPEAT 420..449
FT /note="WD 7"
SQ SEQUENCE 449 AA; 50350 MW; E4C883B6BAE88FF2 CRC64;
MEPRQKGALR GHKNPITCTI VFKDHKRNCN TLVTSDNEGW VAWWDISTKR PLGVWRAHSN
SILSVVQIDH NLLLTHGKDS CVRIWAITQY EGFSKTFPAE NHTESGSHRW PEYVEIPVNT
LNFCNVCYLN GKLITPATQD SNNFDIYSIF PASAAHFPDI ESRLSLRRIV ANADPLALHK
KAKSKENLTM GIDFEISDEN SKRDGFGIMM KVVFVSPTLF YIGYESGHII GFSLTEYKPN
VNVKSKEGTT KAFDASFINK EPTLEIIYIS AFHCPHPITA LFFHDKLYAG SAGKTLSIHT
KQSSIAEEPE IESYNLKIAG VQDIAVLPEL AIVAFWNGVV KGYEKQSTEA ESDQRELTTD
FSTEPNTISQ FKPAWKMSRD VPRIGTLESN NGQKEAQELP SKVKANTLCI LKSSAITHSS
YRDLVRARQV SPRLLTVGYA DGVTIMYEI
