OR2B2_HUMAN
ID OR2B2_HUMAN Reviewed; 357 AA.
AC Q9GZK3; B2RNH2; Q9GZL2; Q9Y299;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Olfactory receptor 2B2;
DE AltName: Full=Hs6M1-10;
DE AltName: Full=Olfactory receptor 2B9;
DE AltName: Full=Olfactory receptor 6-1;
DE Short=OR6-1;
GN Name=OR2B2; Synonyms=OR2B9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-234.
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2B2";
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DR EMBL; AJ302584; CAC20504.1; -; Genomic_DNA.
DR EMBL; AJ302585; CAC20505.1; -; Genomic_DNA.
DR EMBL; AJ302586; CAC20506.1; -; Genomic_DNA.
DR EMBL; AJ302587; CAC20507.1; -; Genomic_DNA.
DR EMBL; AJ302588; CAC20508.1; -; Genomic_DNA.
DR EMBL; AJ302589; CAC20509.1; -; Genomic_DNA.
DR EMBL; AJ302590; CAC20510.1; -; Genomic_DNA.
DR EMBL; AJ302591; CAC20511.1; -; Genomic_DNA.
DR EMBL; AJ302592; CAC20512.1; -; Genomic_DNA.
DR EMBL; AJ302593; CAC20513.1; -; Genomic_DNA.
DR EMBL; Z98744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03125.1; -; Genomic_DNA.
DR EMBL; BC136881; AAI36882.1; -; mRNA.
DR EMBL; BC136901; AAI36902.1; -; mRNA.
DR CCDS; CCDS4641.1; -.
DR RefSeq; NP_149046.2; NM_033057.2.
DR AlphaFoldDB; Q9GZK3; -.
DR SMR; Q9GZK3; -.
DR STRING; 9606.ENSP00000304419; -.
DR GlyGen; Q9GZK3; 1 site.
DR iPTMnet; Q9GZK3; -.
DR PhosphoSitePlus; Q9GZK3; -.
DR BioMuta; OR2B2; -.
DR DMDM; 14423800; -.
DR PaxDb; Q9GZK3; -.
DR PeptideAtlas; Q9GZK3; -.
DR PRIDE; Q9GZK3; -.
DR ProteomicsDB; 80079; -.
DR Antibodypedia; 25824; 62 antibodies from 18 providers.
DR DNASU; 81697; -.
DR Ensembl; ENST00000303324.4; ENSP00000304419.2; ENSG00000168131.4.
DR GeneID; 81697; -.
DR KEGG; hsa:81697; -.
DR MANE-Select; ENST00000303324.4; ENSP00000304419.2; NM_033057.2; NP_149046.2.
DR UCSC; uc011dkw.2; human.
DR CTD; 81697; -.
DR DisGeNET; 81697; -.
DR GeneCards; OR2B2; -.
DR HGNC; HGNC:13966; OR2B2.
DR HPA; ENSG00000168131; Not detected.
DR neXtProt; NX_Q9GZK3; -.
DR PharmGKB; PA32141; -.
DR VEuPathDB; HostDB:ENSG00000168131; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q9GZK3; -.
DR OMA; PLCGHRE; -.
DR OrthoDB; 933513at2759; -.
DR PhylomeDB; Q9GZK3; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q9GZK3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81697; 12 hits in 666 CRISPR screens.
DR GeneWiki; OR2B2; -.
DR GenomeRNAi; 81697; -.
DR Pharos; Q9GZK3; Tdark.
DR PRO; PR:Q9GZK3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9GZK3; protein.
DR Bgee; ENSG00000168131; Expressed in tibialis anterior and 7 other tissues.
DR ExpressionAtlas; Q9GZK3; baseline and differential.
DR Genevisible; Q9GZK3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..357
FT /note="Olfactory receptor 2B2"
FT /id="PRO_0000150460"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 183
FT /note="A -> P (in dbSNP:rs9368537)"
FT /id="VAR_057536"
FT VARIANT 234
FT /note="Q -> R (in allele 6M1-10*02; dbSNP:rs34957169)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_010943"
FT VARIANT 300
FT /note="A -> S (in dbSNP:rs34788973)"
FT /id="VAR_062014"
SQ SEQUENCE 357 AA; 40412 MW; 53E2F82820EC440A CRC64;
MNWVNKSVPQ EFILLVFSDQ PWLEIPPFVM FLFSYILTIF GNLTIILVSH VDFKLHTPMY
FFLSNLSLLD LCYTTSTVPQ MLVNICNTRK VISYGGCVAQ LFIFLALGST ECLLLAVMCF
DRFVAICRPL HYSIIMHQRL CFQLAAASWI SGFSNSVLQS TWTLKMPLCG HKEVDHFFCE
VPALLKLSCV DTTANEAELF FISVLFLLIP VTLILISYAF IVQAVLRIQS AEGQRKAFGT
CGSHLIVVSL FYGTAISMYL QPPSPSSKDR GKMVSLFCGI IAPMLNPLIY TLRNKEVKEA
FKRLVAKSLL NQEIRNMQMI SFAKDTVLTY LTNFSASCPI FVITIENYCN LPQRKFP
