OR2B3_HUMAN
ID OR2B3_HUMAN Reviewed; 313 AA.
AC O76000; B0UYQ1; Q5ST41; Q96R13;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Putative olfactory receptor 2B3;
DE AltName: Full=Hs6M1-1;
DE AltName: Full=Olfactory receptor OR6-14;
DE Short=OR6-4;
DE Short=Olfactory receptor 6-4;
GN Name=OR2B3; Synonyms=OR2B3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2B3";
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DR EMBL; AJ302537; CAC20462.1; -; Genomic_DNA.
DR EMBL; AJ302538; CAC20463.1; -; Genomic_DNA.
DR EMBL; AJ302539; CAC20464.1; -; Genomic_DNA.
DR EMBL; AJ302540; CAC20465.1; -; Genomic_DNA.
DR EMBL; AJ302541; CAC20466.1; -; Genomic_DNA.
DR EMBL; AJ302542; CAC20467.1; -; Genomic_DNA.
DR EMBL; AJ302543; CAC20468.1; -; Genomic_DNA.
DR EMBL; AJ302544; CAC20469.1; -; Genomic_DNA.
DR EMBL; AJ302545; CAC20470.1; -; Genomic_DNA.
DR EMBL; AJ302546; CAC20471.1; -; Genomic_DNA.
DR EMBL; AL022727; CAA18782.1; -; Genomic_DNA.
DR EMBL; AL662852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR547123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR942175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR933783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03182.1; -; Genomic_DNA.
DR EMBL; AF399632; AAK95117.1; -; Genomic_DNA.
DR EMBL; BK004436; DAA04834.1; -; Genomic_DNA.
DR CCDS; CCDS34358.1; -.
DR RefSeq; NP_001005226.1; NM_001005226.2.
DR AlphaFoldDB; O76000; -.
DR SMR; O76000; -.
DR STRING; 9606.ENSP00000366378; -.
DR GlyGen; O76000; 1 site.
DR iPTMnet; O76000; -.
DR PhosphoSitePlus; O76000; -.
DR BioMuta; OR2B3; -.
DR PaxDb; O76000; -.
DR PRIDE; O76000; -.
DR Antibodypedia; 71075; 13 antibodies from 10 providers.
DR DNASU; 442184; -.
DR Ensembl; ENST00000377173.4; ENSP00000366378.2; ENSG00000204703.5.
DR Ensembl; ENST00000383653.3; ENSP00000373149.3; ENSG00000206524.3.
DR Ensembl; ENST00000415976.3; ENSP00000394571.2; ENSG00000226832.3.
DR Ensembl; ENST00000419873.3; ENSP00000394593.2; ENSG00000231319.3.
DR Ensembl; ENST00000420178.3; ENSP00000388604.2; ENSG00000233054.3.
DR Ensembl; ENST00000444830.3; ENSP00000393235.2; ENSG00000233180.3.
DR Ensembl; ENST00000450817.3; ENSP00000399881.2; ENSG00000233687.3.
DR Ensembl; ENST00000456140.3; ENSP00000403571.2; ENSG00000225736.3.
DR GeneID; 442184; -.
DR KEGG; hsa:442184; -.
DR MANE-Select; ENST00000377173.4; ENSP00000366378.2; NM_001005226.2; NP_001005226.1.
DR UCSC; uc003nlx.4; human.
DR CTD; 442184; -.
DR DisGeNET; 442184; -.
DR GeneCards; OR2B3; -.
DR HGNC; HGNC:8238; OR2B3.
DR HPA; ENSG00000204703; Not detected.
DR neXtProt; NX_O76000; -.
DR VEuPathDB; HostDB:ENSG00000204703; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; O76000; -.
DR OMA; LMPRIFF; -.
DR OrthoDB; 857268at2759; -.
DR PhylomeDB; O76000; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; O76000; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 442184; 6 hits in 666 CRISPR screens.
DR GeneWiki; OR2B3; -.
DR GenomeRNAi; 442184; -.
DR Pharos; O76000; Tdark.
DR PRO; PR:O76000; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O76000; protein.
DR Bgee; ENSG00000204703; Expressed in mucosa of transverse colon.
DR ExpressionAtlas; O76000; baseline and differential.
DR Genevisible; O76000; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Putative olfactory receptor 2B3"
FT /id="PRO_0000150461"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 313 AA; 35543 MW; 786BF1EE7B624440 CRC64;
MNWENESSPK EFILLGFSDR AWLQMPLFVV LLISYTITIF GNVSIMMVCI LDPKLHTPMY
FFLTNLSILD LCYTTTTVPH MLVNIGCNKK TISYAGCVAH LIIFLALGAT ECLLLAVMSF
DRYVAVCRPL HYVVIMNYWF CLRMAAFSWL IGFGNSVLQS SLTLNMPRCG HQEVDHFFCE
VPALLKLSCA DTKPIEAELF FFSVLILLIP VTLILISYGF IAQAVLKIRS AEGRQKAFGT
CGSHMIVVSL FYGTAIYMYL QPPSSTSKDW GKMVSLFYGI ITSMLNSLIY SLRNKDMKEA
FKRLMPRIFF CKK
