OR2B6_HUMAN
ID OR2B6_HUMAN Reviewed; 313 AA.
AC P58173; O43883; Q6IF89; Q9H5B0;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Olfactory receptor 2B6;
DE AltName: Full=Hs6M1-32;
DE AltName: Full=Olfactory receptor 2B1;
DE AltName: Full=Olfactory receptor 2B5;
DE AltName: Full=Olfactory receptor 5-40;
DE Short=OR5-40;
DE AltName: Full=Olfactory receptor 6-31;
DE Short=OR6-31;
DE AltName: Full=Olfactory receptor OR6-4;
GN Name=OR2B6; Synonyms=OR2B1, OR2B1P, OR2B5, OR2B6P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=9500546; DOI=10.1038/ng0398-243;
RA Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA Demaille J.G., Giorgi D.;
RT "Distribution of olfactory receptor genes in the human genome.";
RL Nat. Genet. 18:243-250(1998).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR2B6";
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DR EMBL; AL133267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109251; AAI09252.1; -; mRNA.
DR EMBL; BC110457; AAI10458.1; -; mRNA.
DR EMBL; U86270; AAC39628.1; -; Genomic_DNA.
DR EMBL; BK004373; DAA04771.1; -; Genomic_DNA.
DR CCDS; CCDS4642.1; -.
DR RefSeq; NP_036499.1; NM_012367.1.
DR AlphaFoldDB; P58173; -.
DR SMR; P58173; -.
DR IntAct; P58173; 1.
DR STRING; 9606.ENSP00000244623; -.
DR GlyGen; P58173; 1 site.
DR iPTMnet; P58173; -.
DR PhosphoSitePlus; P58173; -.
DR BioMuta; OR2B6; -.
DR DMDM; 14423785; -.
DR PaxDb; P58173; -.
DR PeptideAtlas; P58173; -.
DR PRIDE; P58173; -.
DR ProteomicsDB; 57052; -.
DR Antibodypedia; 67797; 64 antibodies from 17 providers.
DR DNASU; 26212; -.
DR Ensembl; ENST00000244623.1; ENSP00000244623.1; ENSG00000124657.1.
DR GeneID; 26212; -.
DR KEGG; hsa:26212; -.
DR MANE-Select; ENST00000244623.1; ENSP00000244623.1; NM_012367.1; NP_036499.1.
DR UCSC; uc011dkx.2; human.
DR CTD; 26212; -.
DR GeneCards; OR2B6; -.
DR HGNC; HGNC:8241; OR2B6.
DR HPA; ENSG00000124657; Not detected.
DR neXtProt; NX_P58173; -.
DR OpenTargets; ENSG00000124657; -.
DR PharmGKB; PA32144; -.
DR VEuPathDB; HostDB:ENSG00000124657; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; P58173; -.
DR OMA; QMLVNLC; -.
DR OrthoDB; 933513at2759; -.
DR PhylomeDB; P58173; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; P58173; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; P58173; -.
DR BioGRID-ORCS; 26212; 6 hits in 667 CRISPR screens.
DR GeneWiki; OR2B6; -.
DR GenomeRNAi; 26212; -.
DR Pharos; P58173; Tdark.
DR PRO; PR:P58173; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P58173; protein.
DR Bgee; ENSG00000124657; Expressed in mucosa of transverse colon and 48 other tissues.
DR ExpressionAtlas; P58173; baseline and differential.
DR Genevisible; P58173; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 2B6"
FT /id="PRO_0000150462"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 117
FT /note="V -> I (in dbSNP:rs7767176)"
FT /id="VAR_053131"
FT VARIANT 270
FT /note="Q -> R (in dbSNP:rs9380030)"
FT /id="VAR_024090"
SQ SEQUENCE 313 AA; 35414 MW; 71D459541ACF5301 CRC64;
MNWVNDSIIQ EFILLGFSDR PWLEFPLLVV FLISYTVTIF GNLTIILVSR LDTKLHTPMY
FFLTNLSLLD LCYTTCTVPQ MLVNLCSIRK VISYRGCVAQ LFIFLALGAT EYLLLAVMSF
DRFVAICRPL HYSVIMHQRL CLQLAAASWV TGFSNSVWLS TLTLQLPLCD PYVIDHFLCE
VPALLKLSCV ETTANEAELF LVSELFHLIP LTLILISYAF IVRAVLRIQS AEGRQKAFGT
CGSHLIVVSL FYSTAVSVYL QPPSPSSKDQ GKMVSLFYGI IAPMLNPLIY TLRNKEVKEG
FKRLVARVFL IKK
