OR2C1_HUMAN
ID OR2C1_HUMAN Reviewed; 312 AA.
AC O95371; A0AVA4; Q6IF34; Q6IF55;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Olfactory receptor 2C1;
DE AltName: Full=OLFmf3;
DE AltName: Full=Olfactory receptor 2C2;
DE AltName: Full=Olfactory receptor OR16-1;
DE AltName: Full=Olfactory receptor OR16-2;
GN Name=OR2C1; Synonyms=OR2C2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-16; TRP-149 AND
RP HIS-229.
RX PubMed=9847080; DOI=10.1101/gr.8.11.1172;
RA Centola M., Chen X., Sood R., Deng Z., Aksentijevich I., Blake T.,
RA Ricke D.O., Chen X., Wood G., Zaks N., Richards N., Krizman D.,
RA Mansfield E., Apostolou S., Liu J., Shafran N., Vedula A., Hamon M.,
RA Cercek A., Kahan T., Gumucio D., Callen D.F., Richards R.I., Moyzis R.K.,
RA Dogget N.A., Collins F.S., Liu P.P., Fischel-Ghodsian N., Kastner D.L.;
RT "Construction of an approximately 700-kb transcript map around the familial
RT Mediterranean fever locus on human chromosome 16p13.3.";
RL Genome Res. 8:1172-1191(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT TRP-149.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-16; TRP-149 AND
RP HIS-229.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION, AND VARIANT TRP-149.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2C1";
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DR EMBL; AF098664; AAC83557.1; -; Genomic_DNA.
DR EMBL; AC025283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85373.1; -; Genomic_DNA.
DR EMBL; BC069456; AAH69456.1; -; mRNA.
DR EMBL; BC126269; AAI26270.1; -; mRNA.
DR EMBL; BC130328; AAI30329.1; -; mRNA.
DR EMBL; BK004407; DAA04805.1; -; Genomic_DNA.
DR EMBL; BK004428; DAA04826.1; -; Genomic_DNA.
DR CCDS; CCDS10502.1; -.
DR RefSeq; NP_036500.2; NM_012368.2.
DR AlphaFoldDB; O95371; -.
DR SMR; O95371; -.
DR STRING; 9606.ENSP00000307726; -.
DR GlyGen; O95371; 1 site.
DR iPTMnet; O95371; -.
DR PhosphoSitePlus; O95371; -.
DR BioMuta; OR2C1; -.
DR PaxDb; O95371; -.
DR PeptideAtlas; O95371; -.
DR PRIDE; O95371; -.
DR Antibodypedia; 24106; 55 antibodies from 16 providers.
DR DNASU; 4993; -.
DR Ensembl; ENST00000304936.4; ENSP00000307726.2; ENSG00000168158.4.
DR GeneID; 4993; -.
DR KEGG; hsa:4993; -.
DR MANE-Select; ENST00000304936.4; ENSP00000307726.2; NM_012368.3; NP_036500.2.
DR UCSC; uc002cuw.2; human.
DR CTD; 4993; -.
DR GeneCards; OR2C1; -.
DR HGNC; HGNC:8242; OR2C1.
DR HPA; ENSG00000168158; Not detected.
DR neXtProt; NX_O95371; -.
DR PharmGKB; PA32147; -.
DR VEuPathDB; HostDB:ENSG00000168158; -.
DR eggNOG; ENOG502RCDM; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O95371; -.
DR OMA; QLEMVFF; -.
DR OrthoDB; 1136762at2759; -.
DR PhylomeDB; O95371; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; O95371; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 4993; 7 hits in 669 CRISPR screens.
DR GeneWiki; OR2C1; -.
DR GenomeRNAi; 4993; -.
DR Pharos; O95371; Tdark.
DR PRO; PR:O95371; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; O95371; protein.
DR Bgee; ENSG00000168158; Expressed in tibialis anterior and 27 other tissues.
DR Genevisible; O95371; HS.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IEA:Ensembl.
DR GO; GO:0004984; F:olfactory receptor activity; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2C1"
FT /id="PRO_0000150465"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 16
FT /note="G -> S (in dbSNP:rs1218762)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9847080"
FT /id="VAR_047490"
FT VARIANT 149
FT /note="C -> W (in dbSNP:rs1218763)"
FT /evidence="ECO:0000269|PubMed:14983052,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9847080,
FT ECO:0000269|Ref.3"
FT /id="VAR_047491"
FT VARIANT 229
FT /note="R -> H (in dbSNP:rs11648783)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9847080"
FT /id="VAR_047492"
SQ SEQUENCE 312 AA; 34412 MW; 33A2697D06ED8E9E CRC64;
MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR LEARLHTPMY
FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ LYVFLWLGAT ECILLVVMAF
DRYVAVCRPL RYTAIMNPQL CWLLAVIACL GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE
VPAMIKLACG DTSLNQAVLN GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT
CLSHLLVVFL FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA
LRRLLGKGRE VG
