OR2C3_HUMAN
ID OR2C3_HUMAN Reviewed; 320 AA.
AC Q8N628; Q5JQS4; Q6IEZ1; Q8NGW7;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Olfactory receptor 2C3;
DE AltName: Full=Olfactory receptor 2C4;
DE AltName: Full=Olfactory receptor 2C5;
DE AltName: Full=Olfactory receptor OR1-30;
GN Name=OR2C3; Synonyms=OR2C4, OR2C5P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-20 AND SER-68.
RC TISSUE=Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30717.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=DAA04869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2C3";
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DR EMBL; AB065649; BAC05875.1; -; Genomic_DNA.
DR EMBL; AL606804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030717; AAH30717.1; ALT_INIT; mRNA.
DR EMBL; BK004471; DAA04869.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS1634.2; -.
DR RefSeq; NP_932340.3; NM_198074.4.
DR AlphaFoldDB; Q8N628; -.
DR SMR; Q8N628; -.
DR STRING; 9606.ENSP00000355443; -.
DR GlyGen; Q8N628; 1 site.
DR BioMuta; OR2C3; -.
DR DMDM; 218512126; -.
DR PaxDb; Q8N628; -.
DR PeptideAtlas; Q8N628; -.
DR PRIDE; Q8N628; -.
DR Antibodypedia; 34728; 110 antibodies from 23 providers.
DR DNASU; 81472; -.
DR Ensembl; ENST00000366487.4; ENSP00000355443.3; ENSG00000196242.10.
DR Ensembl; ENST00000641802.1; ENSP00000493385.1; ENSG00000196242.10.
DR GeneID; 81472; -.
DR KEGG; hsa:81472; -.
DR MANE-Select; ENST00000641802.1; ENSP00000493385.1; NM_198074.6; NP_932340.4.
DR UCSC; uc009xgy.3; human.
DR CTD; 81472; -.
DR GeneCards; OR2C3; -.
DR HGNC; HGNC:15005; OR2C3.
DR HPA; ENSG00000196242; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q8N628; -.
DR PharmGKB; PA32149; -.
DR VEuPathDB; HostDB:ENSG00000196242; -.
DR eggNOG; ENOG502RU2D; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8N628; -.
DR OMA; HTVLENC; -.
DR OrthoDB; 835167at2759; -.
DR PhylomeDB; Q8N628; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8N628; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81472; 13 hits in 675 CRISPR screens.
DR GeneWiki; OR2C3; -.
DR GenomeRNAi; 81472; -.
DR Pharos; Q8N628; Tdark.
DR PRO; PR:Q8N628; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N628; protein.
DR Bgee; ENSG00000196242; Expressed in ganglionic eminence and 44 other tissues.
DR Genevisible; Q8N628; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 2C3"
FT /id="PRO_0000150466"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="T -> A (in dbSNP:rs6697472)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025540"
FT VARIANT 68
FT /note="P -> S (in dbSNP:rs6657127)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025541"
FT VARIANT 129
FT /note="R -> S (in dbSNP:rs34220133)"
FT /id="VAR_046378"
FT VARIANT 289
FT /note="L -> V (in dbSNP:rs6702693)"
FT /id="VAR_062016"
SQ SEQUENCE 320 AA; 35376 MW; 52C8143CB927E2FF CRC64;
MMEIANVSSP EVFVLLGFST RPSLETVLFI VVLSFYMVSI LGNGIIILVS HTDVHLHTPM
YFFLANLPFL DMSFTTSIVP QLLANLWGPQ KTISYGGCVV QFYISHWLGA TECVLLATMS
YDRYAAICRP LHYTVIMHPQ LCLGLALASW LGGLTTSMVG STLTMLLPLC GNNCIDHFFC
EMPLIMQLAC VDTSLNEMEM YLASFVFVVL PLGLILVSYG HIARAVLKIR SAEGRRKAFN
TCSSHVAVVS LFYGSIIFMY LQPAKSTSHE QGKFIALFYT VVTPALNPLI YTLRNTEVKS
ALRHMVLENC CGSAGKLAQI
