OR2D2_HUMAN
ID OR2D2_HUMAN Reviewed; 308 AA.
AC Q9H210; B9EIL5; O95224; Q6IF28; Q8NGH4; Q96R52;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 4.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Olfactory receptor 2D2;
DE AltName: Full=HB2;
DE AltName: Full=Olfactory receptor 11-610;
DE Short=OR11-610;
DE AltName: Full=Olfactory receptor 2D1;
DE AltName: Full=Olfactory receptor OR11-88;
GN Name=OR2D2; Synonyms=OR2D1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-163 AND THR-202.
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-163.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-163.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-283, AND VARIANTS THR-163 AND
RP THR-202.
RX PubMed=9787077; DOI=10.1006/geno.1998.5422;
RA Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.;
RT "Organization and evolution of olfactory receptor genes on human chromosome
RT 11.";
RL Genomics 53:56-68(1998).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-281, AND VARIANTS THR-163 AND
RP THR-202.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [7]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [8]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2D2";
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DR EMBL; AF321237; AAG45204.1; -; Genomic_DNA.
DR EMBL; AB065824; BAC06043.1; -; Genomic_DNA.
DR EMBL; CH471064; EAW68673.1; -; Genomic_DNA.
DR EMBL; BC140729; AAI40730.1; -; mRNA.
DR EMBL; AF065876; AAC70020.1; -; Genomic_DNA.
DR EMBL; AF399591; AAK95076.1; -; Genomic_DNA.
DR EMBL; BK004434; DAA04832.1; -; Genomic_DNA.
DR CCDS; CCDS31416.1; -.
DR RefSeq; NP_003691.1; NM_003700.1.
DR AlphaFoldDB; Q9H210; -.
DR SMR; Q9H210; -.
DR STRING; 9606.ENSP00000299459; -.
DR GlyGen; Q9H210; 1 site.
DR iPTMnet; Q9H210; -.
DR PhosphoSitePlus; Q9H210; -.
DR BioMuta; OR2D2; -.
DR DMDM; 209572777; -.
DR MassIVE; Q9H210; -.
DR PaxDb; Q9H210; -.
DR PeptideAtlas; Q9H210; -.
DR PRIDE; Q9H210; -.
DR Antibodypedia; 56604; 28 antibodies from 13 providers.
DR DNASU; 120776; -.
DR Ensembl; ENST00000299459.3; ENSP00000299459.2; ENSG00000166368.3.
DR GeneID; 120776; -.
DR KEGG; hsa:120776; -.
DR MANE-Select; ENST00000299459.3; ENSP00000299459.2; NM_003700.1; NP_003691.1.
DR UCSC; uc010rau.3; human.
DR CTD; 120776; -.
DR GeneCards; OR2D2; -.
DR HGNC; HGNC:8244; OR2D2.
DR HPA; ENSG00000166368; Not detected.
DR MIM; 608494; gene.
DR neXtProt; NX_Q9H210; -.
DR OpenTargets; ENSG00000166368; -.
DR PharmGKB; PA32152; -.
DR VEuPathDB; HostDB:ENSG00000166368; -.
DR eggNOG; ENOG502SKP3; Eukaryota.
DR GeneTree; ENSGT01050000244837; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9H210; -.
DR OMA; NTQQLLF; -.
DR OrthoDB; 874304at2759; -.
DR PhylomeDB; Q9H210; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q9H210; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 120776; 10 hits in 668 CRISPR screens.
DR GeneWiki; OR2D2; -.
DR GenomeRNAi; 120776; -.
DR Pharos; Q9H210; Tdark.
DR PRO; PR:Q9H210; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H210; protein.
DR Bgee; ENSG00000166368; Expressed in mucosa of transverse colon and 6 other tissues.
DR ExpressionAtlas; Q9H210; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 2D2"
FT /id="PRO_0000150467"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 84
FT /note="H -> Y (in dbSNP:rs57896484)"
FT /id="VAR_062017"
FT VARIANT 148
FT /note="S -> P (in dbSNP:rs1965209)"
FT /id="VAR_046723"
FT VARIANT 163
FT /note="I -> M (in dbSNP:rs1965207)"
FT /id="VAR_046724"
FT VARIANT 163
FT /note="I -> T (in dbSNP:rs1965208)"
FT /evidence="ECO:0000269|PubMed:11416212,
FT ECO:0000269|PubMed:12213199, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9787077, ECO:0000269|Ref.3"
FT /id="VAR_046725"
FT VARIANT 202
FT /note="M -> T (in dbSNP:rs2741804)"
FT /evidence="ECO:0000269|PubMed:11416212,
FT ECO:0000269|PubMed:12213199, ECO:0000269|PubMed:9787077"
FT /id="VAR_046726"
FT VARIANT 220
FT /note="R -> G (in dbSNP:rs60116285)"
FT /id="VAR_062018"
FT CONFLICT 134
FT /note="N -> D (in Ref. 5; AAC70020 and 6; AAK95076)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 34172 MW; E3A7471570625CE4 CRC64;
MRQINQTQVT EFLLLGLSDG PHTEQLLFIV LLGVYLVTVL GNLLLISLVH VDSQLHTPMY
FFLCNLSLAD LCFSTNIVPQ ALVHLLSRKK VIAFTLCAAR LLFFLIFGCT QCALLAVMSY
DRYVAICNPL RYPNIMTWKV CVQLATGSWT SGILVSVVDT TFILRLPYRG SNSIAHFFCE
APALLILAST DTHASEMAIF LMGVVILLIP VFLILVSYGR IIVTVVKMKS TVGSLKAFST
CGSHLMVVIL FYGSAIITYM TPKSSKQQEK SVSVFYAIVT PMLNPLIYSL RNKDVKAALR
KVATRNFP
