OR2D3_HUMAN
ID OR2D3_HUMAN Reviewed; 330 AA.
AC Q8NGH3; B2RP06; Q6IFG8; Q96R51;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 2D3;
DE AltName: Full=Olfactory receptor OR11-89;
GN Name=OR2D3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TRP-155.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-299.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06044.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2D3";
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DR EMBL; AB065825; BAC06044.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC137208; AAI37209.1; -; mRNA.
DR EMBL; BC137209; AAI37210.1; -; mRNA.
DR EMBL; AF399592; AAK95077.1; -; Genomic_DNA.
DR EMBL; BK004294; DAA04692.1; -; Genomic_DNA.
DR CCDS; CCDS31417.1; -.
DR RefSeq; NP_001004684.1; NM_001004684.1.
DR AlphaFoldDB; Q8NGH3; -.
DR SMR; Q8NGH3; -.
DR STRING; 9606.ENSP00000320560; -.
DR GlyGen; Q8NGH3; 1 site.
DR iPTMnet; Q8NGH3; -.
DR PhosphoSitePlus; Q8NGH3; -.
DR BioMuta; OR2D3; -.
DR DMDM; 223590116; -.
DR MassIVE; Q8NGH3; -.
DR PaxDb; Q8NGH3; -.
DR PeptideAtlas; Q8NGH3; -.
DR PRIDE; Q8NGH3; -.
DR ProteomicsDB; 73511; -.
DR Antibodypedia; 23971; 64 antibodies from 19 providers.
DR DNASU; 120775; -.
DR Ensembl; ENST00000317834.5; ENSP00000320560.3; ENSG00000178358.5.
DR GeneID; 120775; -.
DR KEGG; hsa:120775; -.
DR MANE-Select; ENST00000317834.5; ENSP00000320560.3; NM_001004684.1; NP_001004684.1.
DR UCSC; uc010rav.3; human.
DR CTD; 120775; -.
DR GeneCards; OR2D3; -.
DR HGNC; HGNC:15146; OR2D3.
DR HPA; ENSG00000178358; Not detected.
DR neXtProt; NX_Q8NGH3; -.
DR PharmGKB; PA32153; -.
DR VEuPathDB; HostDB:ENSG00000178358; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244837; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGH3; -.
DR OMA; TFHLPYW; -.
DR OrthoDB; 1020339at2759; -.
DR PhylomeDB; Q8NGH3; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGH3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGH3; -.
DR BioGRID-ORCS; 120775; 7 hits in 672 CRISPR screens.
DR GeneWiki; OR2D3; -.
DR GenomeRNAi; 120775; -.
DR Pharos; Q8NGH3; Tdark.
DR PRO; PR:Q8NGH3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGH3; protein.
DR Bgee; ENSG00000178358; Expressed in bone marrow cell and 6 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Olfactory receptor 2D3"
FT /id="PRO_0000150468"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..235
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 82
FT /note="L -> I (in dbSNP:rs10839658)"
FT /id="VAR_057537"
FT VARIANT 155
FT /note="R -> W (in dbSNP:rs12806437)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_057538"
FT VARIANT 165
FT /note="W -> S (in dbSNP:rs10839659)"
FT /id="VAR_057539"
SQ SEQUENCE 330 AA; 37489 MW; A829F400F34E3DEB CRC64;
MCSFFLCQTG KQAKISMGEE NQTFVSKFIF LGLSQDLQTQ ILLFILFLII YLLTVLGNQL
IIILIFLDSR LHTPMYFFLR NLSFADLCFS TSIVPQVLVH FLVKRKTISF YGCMTQIIVF
LLVGCTECAL LAVMSYDRYV AVCKPLYYST IMTQRVCLWL SFRSWASGAL VSLVDTSFTF
HLPYWGQNII NHYFCEPPAL LKLASIDTYS TEMAIFSMGV VILLAPVSLI LGSYWNIIST
VIQMQSGEGR LKAFSTCGSH LIVVVLFYGS GIFTYMRPNS KTTKELDKMI SVFYTAVTPM
LNPIIYSLRN KDVKGALRKL VGRKCFSHRQ
