ID   A2MGH_DEIRA             Reviewed;        1013 AA.
AC   Q9RYL9;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Alpha-2-macroglobulin homolog {ECO:0000305};
GN   OrderedLocusNames=DR_A0293;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved thioester bond that is characteristic of
CC       the alpha-2-macroglobulins. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001825; AAF12520.1; -; Genomic_DNA.
DR   PIR; B75583; B75583.
DR   RefSeq; NP_285616.1; NC_001264.1.
DR   RefSeq; WP_010889552.1; NC_001264.1.
DR   AlphaFoldDB; Q9RYL9; -.
DR   SMR; Q9RYL9; -.
DR   STRING; 243230.DR_A0293; -.
DR   PRIDE; Q9RYL9; -.
DR   EnsemblBacteria; AAF12520; AAF12520; DR_A0293.
DR   KEGG; dra:DR_A0293; -.
DR   PATRIC; fig|243230.17.peg.3184; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_297314_0_0_0; -.
DR   InParanoid; Q9RYL9; -.
DR   OMA; YGCAEQR; -.
DR   OrthoDB; 231654at2; -.
DR   Proteomes; UP000002524; Chromosome II.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1013
FT                   /note="Alpha-2-macroglobulin homolog"
FT                   /id="PRO_0000218151"
FT   REGION          804..844
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1013 AA;  106829 MW;  DBB7A168D2ACE773 CRC64;
     MLGAVVVRVT DLNLVSVATP GRVQVWATRL GSGAPVPNVQ LSALAVKYDW QDGSRVVSRR
     TLAPVRTDAQ GLATFSLRDG EQLSVRGQVT LGGQPHSAQL GRTENELWTG VAERARALIQ
     TDKPVYRPGE TLRGFAVLRR LGAGTRLPYT GPVTVRLRAG YPDATLAQLT VKPDADGLVR
     FSLPLPQDVK IGGYSLEVEL PAAPSASNPN PEPDVSQVPV EVRAFVKPLF TLDLSGPQEV
     VSGTPLTLSA RGELYQGGPA NVQAEAFMVD GYASDELYPD YDAGDNGLRY QDLNSDEVYG
     ENAAPGIDPK RRPDQTLTLR GGRATLPLKL QAKNGQPTRY AVALRARDEY GRDVWARRPV
     TVYPAAIKFV QPRVEGAERR RVSVAVQQVG SGKALAGRRV QAEVVRVFYV TQPDGKSVRR
     EQRISQSVLT SDAAGRVTLN VTLTPGQEGG YVARLSTQDS AGRTARASLD IGSVYKSGAE
     RQAPTLVLSP ERSRYQPGDT ARLTLNTDLP VGTPLLLSVN AEDRGQVKLI QVTGPTMTLT
     WPVTAALGPA FSVSAVAVRG GQTAQAFSGE LLVPRFDQRL DVQVTAGSEV KPGAEVTFTV
     RTSRGGQPAS ALVTLAAVHE SVYAVVGDPT PNPWRFLWGA TTPQFEIRSS SSQADDGRGG
     GGGSEAVFYR SDLREVAAFQ AVRTDAQGTA KVTVRMPEGL GSYRLSARAF TRTGAAGEAR
     GEQRVGLPFA VRLIRPRVLT AGDTGSVAVS AADRTGQGGN VTLTLGANGQ TQTANSPLQG
     GSATRLFSIK APQDAQALTL TASAQRGANG ERDGLRETVP VRPAGARQLL SGSGSVGADK
     AGGNASVSLK WPQEAQPESL TLDLAATPLQ LALTGLDAAL ADPADRWVTT DALSARLSSN
     LDLAALAGPF GWPEVRTRAL AQARRDLASL LALRGSDGWG WTEGSPASAE MTARALDALV
     QAKGAGLTDA VTLQVVRQQA ELLLKKSPNS PVLAAGWRGL GPPLRPCDWP APG