OR2F1_HUMAN
ID OR2F1_HUMAN Reviewed; 317 AA.
AC Q13607; A4D2G1; Q6IFP7; Q96R49; Q9UDX1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Olfactory receptor 2F1;
DE AltName: Full=Olfactory receptor 2F3;
DE AltName: Full=Olfactory receptor 2F4;
DE AltName: Full=Olfactory receptor 2F5;
DE AltName: Full=Olfactory receptor-like protein OLF3;
GN Name=OR2F1; Synonyms=OLF3, OR2F3, OR2F3P, OR2F4, OR2F5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9017400; DOI=10.1093/genetics/145.1.185;
RA Issel-Tarver L., Rine J.;
RT "The evolution of mammalian olfactory receptor genes.";
RL Genetics 145:185-195(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [7]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [8]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2F1";
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DR EMBL; U56421; AAB01215.1; -; Genomic_DNA.
DR EMBL; AC004853; AAC64376.1; -; Genomic_DNA.
DR EMBL; CH236959; EAL23795.1; -; Genomic_DNA.
DR EMBL; CH878732; EAW55625.1; -; Genomic_DNA.
DR EMBL; BC104975; AAI04976.1; -; mRNA.
DR EMBL; AF399594; AAK95079.1; -; Genomic_DNA.
DR EMBL; BK004215; DAA04613.1; -; Genomic_DNA.
DR RefSeq; NP_036501.2; NM_012369.2.
DR RefSeq; XP_011514321.1; XM_011516019.2.
DR RefSeq; XP_011514322.1; XM_011516020.2.
DR AlphaFoldDB; Q13607; -.
DR SMR; Q13607; -.
DR STRING; 9606.ENSP00000485535; -.
DR GlyGen; Q13607; 1 site.
DR iPTMnet; Q13607; -.
DR PhosphoSitePlus; Q13607; -.
DR BioMuta; OR2F1; -.
DR DMDM; 9297120; -.
DR PaxDb; Q13607; -.
DR PeptideAtlas; Q13607; -.
DR PRIDE; Q13607; -.
DR Antibodypedia; 32698; 10 antibodies from 8 providers.
DR DNASU; 26211; -.
DR Ensembl; ENST00000624504.1; ENSP00000485483.1; ENSG00000213215.5.
DR Ensembl; ENST00000641412.1; ENSP00000493004.1; ENSG00000213215.5.
DR Ensembl; ENST00000643449.1; ENSP00000495065.1; ENSG00000284866.1.
DR Ensembl; ENST00000646094.1; ENSP00000496442.1; ENSG00000284866.1.
DR GeneID; 26211; -.
DR KEGG; hsa:26211; -.
DR MANE-Select; ENST00000641412.1; ENSP00000493004.1; NM_012369.3; NP_036501.2.
DR UCSC; uc003wds.1; human.
DR CTD; 26211; -.
DR GeneCards; OR2F1; -.
DR HGNC; HGNC:8246; OR2F1.
DR HPA; ENSG00000213215; Not detected.
DR MIM; 608497; gene.
DR neXtProt; NX_Q13607; -.
DR PharmGKB; PA32155; -.
DR VEuPathDB; HostDB:ENSG00000213215; -.
DR eggNOG; ENOG502SKV6; Eukaryota.
DR GeneTree; ENSGT01050000244837; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q13607; -.
DR OMA; VFLMTPF; -.
DR OrthoDB; 874222at2759; -.
DR PhylomeDB; Q13607; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q13607; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26211; 10 hits in 635 CRISPR screens.
DR ChiTaRS; OR2F1; human.
DR GeneWiki; OR2F1; -.
DR GenomeRNAi; 26211; -.
DR Pharos; Q13607; Tdark.
DR PRO; PR:Q13607; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q13607; protein.
DR Bgee; ENSG00000213215; Expressed in tibial artery and 89 other tissues.
DR ExpressionAtlas; Q13607; baseline and differential.
DR Genevisible; Q13607; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 2F1"
FT /id="PRO_0000150469"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 122
FT /note="R -> C (in dbSNP:rs2072164)"
FT /id="VAR_053136"
FT VARIANT 137
FT /note="H -> R (in dbSNP:rs2072165)"
FT /id="VAR_053137"
FT CONFLICT 211
FT /note="F -> L (in Ref. 1; AAB01215)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 35350 MW; A72ADE1AEB6680CE CRC64;
MGTDNQTWVS EFILLGLSSD WDTRVSLFVL FLVMYVVTVL GNCLIVLLIR LDSRLHTPMY
FFLTNLSLVD VSYATSVVPQ LLAHFLAEHK AIPFQSCAAQ LFFSLALGGI EFVLLAVMAY
DRYVAVCDAL RYSAIMHGGL CARLAITSWV SGFISSPVQT AITFQLPMCR NKFIDHISCE
LLAVVRLACV DTSSNEVTIM VSSIVLLMTP FCLVLLSYIQ IISTILKIQS REGRKKAFHT
CASHLTVVAL CYGVAIFTYI QPHSSPSVLQ EKLFSVFYAI LTPMLNPMIY SLRNKEVKGA
WQKLLWKFSG LTSKLAT
