OR2G2_HUMAN
ID OR2G2_HUMAN Reviewed; 317 AA.
AC Q8NGZ5; Q5JQT2; Q6IEZ0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 2G2;
DE AltName: Full=Olfactory receptor OR1-32;
GN Name=OR2G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04870.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2G2";
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DR EMBL; AB065621; BAC05847.1; -; Genomic_DNA.
DR EMBL; AL606804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004472; DAA04870.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS31092.1; -.
DR RefSeq; NP_001001915.1; NM_001001915.1.
DR AlphaFoldDB; Q8NGZ5; -.
DR SMR; Q8NGZ5; -.
DR STRING; 9606.ENSP00000326349; -.
DR GlyGen; Q8NGZ5; 1 site.
DR iPTMnet; Q8NGZ5; -.
DR PhosphoSitePlus; Q8NGZ5; -.
DR BioMuta; OR2G2; -.
DR DMDM; 38372795; -.
DR PaxDb; Q8NGZ5; -.
DR PeptideAtlas; Q8NGZ5; -.
DR PRIDE; Q8NGZ5; -.
DR Antibodypedia; 34729; 48 antibodies from 16 providers.
DR DNASU; 81470; -.
DR Ensembl; ENST00000320065.1; ENSP00000326349.1; ENSG00000177489.1.
DR GeneID; 81470; -.
DR KEGG; hsa:81470; -.
DR MANE-Select; ENST00000320065.1; ENSP00000326349.1; NM_001001915.1; NP_001001915.1.
DR UCSC; uc010pyy.2; human.
DR CTD; 81470; -.
DR GeneCards; OR2G2; -.
DR HGNC; HGNC:15007; OR2G2.
DR HPA; ENSG00000177489; Not detected.
DR neXtProt; NX_Q8NGZ5; -.
DR OpenTargets; ENSG00000177489; -.
DR PharmGKB; PA32159; -.
DR VEuPathDB; HostDB:ENSG00000177489; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGZ5; -.
DR OMA; LWEPMKT; -.
DR OrthoDB; 957101at2759; -.
DR PhylomeDB; Q8NGZ5; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NGZ5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81470; 16 hits in 677 CRISPR screens.
DR GeneWiki; OR2G2; -.
DR GenomeRNAi; 81470; -.
DR Pharos; Q8NGZ5; Tdark.
DR PRO; PR:Q8NGZ5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGZ5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 2G2"
FT /id="PRO_0000150476"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 24
FT /note="P -> A (in dbSNP:rs12737801)"
FT /id="VAR_034174"
FT VARIANT 120
FT /note="V -> L (in dbSNP:rs1151687)"
FT /id="VAR_034175"
FT VARIANT 167
FT /note="L -> P (in dbSNP:rs10925085)"
FT /id="VAR_034176"
FT VARIANT 236
FT /note="R -> G (in dbSNP:rs869111)"
FT /id="VAR_034177"
SQ SEQUENCE 317 AA; 35559 MW; 30A6D6A56EB1BBEC CRC64;
MGMVRHTNES NLAGFILLGF SDYPQLQKVL FVLILILYLL TILGNTTIIL VSRLEPKLHM
PMYFFLSHLS FLYRCFTSSV IPQLLVNLWE PMKTIAYGGC LVHLYNSHAL GSTECVLPAV
MSCDRYVAVC RPLHYTVLMH IHLCMALASM AWLSGIATTL VQSTLTLQLP FCGHRQVDHF
ICEVPVLIKL ACVGTTFNEA ELFVASILFL IVPVSFILVS SGYIAHAVLR IKSATRRQKA
FGTCFSHLTV VTIFYGTIIF MYLQPAKSRS RDQGKFVSLF YTVVTRMLNP LIYTLRIKEV
KGALKKVLAK ALGVNIL
