OR2G6_HUMAN
ID OR2G6_HUMAN Reviewed; 316 AA.
AC Q5TZ20; B2RP33;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Olfactory receptor 2G6;
GN Name=OR2G6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q5TZ20; Q00526: CDK3; NbExp=3; IntAct=EBI-13334799, EBI-1245761;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2G6";
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DR EMBL; BX537158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471148; EAW77231.1; -; Genomic_DNA.
DR EMBL; BC137245; AAI37246.1; -; mRNA.
DR EMBL; BC137266; AAI37267.1; -; mRNA.
DR CCDS; CCDS31119.1; -.
DR RefSeq; NP_001013373.1; NM_001013355.1.
DR AlphaFoldDB; Q5TZ20; -.
DR SMR; Q5TZ20; -.
DR BioGRID; 133856; 19.
DR IntAct; Q5TZ20; 1.
DR STRING; 9606.ENSP00000341291; -.
DR GlyGen; Q5TZ20; 2 sites.
DR iPTMnet; Q5TZ20; -.
DR PhosphoSitePlus; Q5TZ20; -.
DR BioMuta; OR2G6; -.
DR DMDM; 74762248; -.
DR PaxDb; Q5TZ20; -.
DR PeptideAtlas; Q5TZ20; -.
DR PRIDE; Q5TZ20; -.
DR Antibodypedia; 68599; 74 antibodies from 17 providers.
DR DNASU; 391211; -.
DR Ensembl; ENST00000641501.1; ENSP00000492940.1; ENSG00000188558.7.
DR Ensembl; ENST00000641804.1; ENSP00000493355.1; ENSG00000188558.7.
DR GeneID; 391211; -.
DR KEGG; hsa:391211; -.
DR MANE-Select; ENST00000641804.1; ENSP00000493355.1; NM_001013355.2; NP_001013373.1.
DR UCSC; uc001ien.1; human.
DR CTD; 391211; -.
DR GeneCards; OR2G6; -.
DR HGNC; HGNC:27019; OR2G6.
DR HPA; ENSG00000188558; Not detected.
DR neXtProt; NX_Q5TZ20; -.
DR PharmGKB; PA142671228; -.
DR VEuPathDB; HostDB:ENSG00000188558; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q5TZ20; -.
DR OMA; FVIILHF; -.
DR OrthoDB; 908470at2759; -.
DR PhylomeDB; Q5TZ20; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q5TZ20; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q5TZ20; -.
DR BioGRID-ORCS; 391211; 10 hits in 674 CRISPR screens.
DR GeneWiki; OR2G6; -.
DR GenomeRNAi; 391211; -.
DR Pharos; Q5TZ20; Tdark.
DR PRO; PR:Q5TZ20; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TZ20; protein.
DR Bgee; ENSG00000188558; Expressed in adult mammalian kidney and 2 other tissues.
DR ExpressionAtlas; Q5TZ20; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 2G6"
FT /id="PRO_0000150478"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 59
FT /note="M -> V (in dbSNP:rs58955396)"
FT /id="VAR_062020"
FT VARIANT 258
FT /note="M -> L (in dbSNP:rs9330305)"
FT /id="VAR_053142"
SQ SEQUENCE 316 AA; 34890 MW; 2702925101A6CA34 CRC64;
MEETNNSSEK GFLLLGFSDQ PQLERFLFAI ILYFYVLSLL GNTALILVCC LDSRLHTPMY
FFLSNLSCVD ICFTTSVAPQ LLVTMNKKDK TMSYGGCVAQ LYVAMGLGSS ECILLAVMAY
DRYAAVCRPL RYIAIMHPRF CASLAGGAWL SGLITSLIQC SLTVQLPLCG HRTLDHIFCE
VPVLIKLACV DTTFNEAELF VASVVFLIVP VLLILVSYGF ITQAVLRIKS AAGRQKAFGT
CSSHLVVVII FYGTIIFMYL QPANRRSKNQ GKFVSLFYTI VTPLLNPIIY TLRNKDVKGA
LRTLILGSAA GQSHKD
