OR2H1_HUMAN
ID OR2H1_HUMAN Reviewed; 316 AA.
AC Q9GZK4; B0S7T4; O43629; O43661; O43662; Q5SUN6; Q9GZK9;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Olfactory receptor 2H1;
DE AltName: Full=Hs6M1-16;
DE AltName: Full=OLFR42A-9004.14/9026.2;
DE AltName: Full=Olfactory receptor 2H6;
DE AltName: Full=Olfactory receptor 2H8;
DE AltName: Full=Olfactory receptor 6-2;
DE Short=OR6-2;
DE AltName: Full=Olfactory receptor OR6-32;
GN Name=OR2H1; Synonyms=OR2H6, OR2H8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASN-63.
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12637542; DOI=10.1074/jbc.m212424200;
RA Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D.,
RA Beck S., Ziegler A.;
RT "Complex transcription and splicing of odorant receptor genes.";
RL J. Biol. Chem. 278:19691-19701(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-251.
RA Gallinaro H.;
RT "Olfactory receptor gene cluster in man and mouse major histocompatibility
RT complex.";
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-251.
RA Amadou C., Avoustin P., Ribouchon M.-T., Bouissou C., Tazi-Ahnini R.,
RA Ayer C., Pontarotti P.;
RT "Olfactory receptor gene cluster in man and mouse major histocompatibility
RT complex.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [10]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2H1";
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DR EMBL; AJ302604; CAC20524.1; -; Genomic_DNA.
DR EMBL; AJ302605; CAC20525.1; -; Genomic_DNA.
DR EMBL; AJ302606; CAC20526.1; -; Genomic_DNA.
DR EMBL; AJ302607; CAC20527.1; -; Genomic_DNA.
DR EMBL; AJ302608; CAC20528.1; -; Genomic_DNA.
DR EMBL; AJ302609; CAC20529.1; -; Genomic_DNA.
DR EMBL; AJ302610; CAC20530.1; -; Genomic_DNA.
DR EMBL; AJ302611; CAC20531.1; -; Genomic_DNA.
DR EMBL; AJ302612; CAC20532.1; -; Genomic_DNA.
DR EMBL; AJ302613; CAC20533.1; -; Genomic_DNA.
DR EMBL; AJ459847; CAD31039.1; -; mRNA.
DR EMBL; AK127984; BAG54612.1; -; mRNA.
DR EMBL; AL035542; CAB44506.1; -; Genomic_DNA.
DR EMBL; AL645927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX000531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX247947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03195.1; -; Genomic_DNA.
DR EMBL; BC048991; AAH48991.1; -; mRNA.
DR EMBL; AF042078; AAC00184.1; -; Genomic_DNA.
DR EMBL; AF044491; AAC00188.1; -; Genomic_DNA.
DR EMBL; AF044492; AAC00189.1; -; Genomic_DNA.
DR EMBL; BK004209; DAA04607.1; -; Genomic_DNA.
DR CCDS; CCDS4660.1; -.
DR RefSeq; NP_001304943.1; NM_001318014.1.
DR RefSeq; NP_001304951.1; NM_001318022.1.
DR RefSeq; NP_112145.1; NM_030883.4.
DR RefSeq; XP_011512772.1; XM_011514470.2.
DR RefSeq; XP_011512774.1; XM_011514472.2.
DR RefSeq; XP_011512775.1; XM_011514473.2.
DR RefSeq; XP_011512781.1; XM_011514479.2.
DR RefSeq; XP_011512785.1; XM_011514483.2.
DR RefSeq; XP_011512786.1; XM_011514484.2.
DR RefSeq; XP_016866226.1; XM_017010737.1.
DR RefSeq; XP_016866227.1; XM_017010738.1.
DR RefSeq; XP_016866228.1; XM_017010739.1.
DR AlphaFoldDB; Q9GZK4; -.
DR SMR; Q9GZK4; -.
DR BioGRID; 117800; 1.
DR IntAct; Q9GZK4; 1.
DR STRING; 9606.ENSP00000366340; -.
DR GlyGen; Q9GZK4; 1 site.
DR BioMuta; OR2H1; -.
DR DMDM; 14423801; -.
DR PaxDb; Q9GZK4; -.
DR PRIDE; Q9GZK4; -.
DR Antibodypedia; 25966; 79 antibodies from 19 providers.
DR DNASU; 26716; -.
DR Ensembl; ENST00000377132.1; ENSP00000366336.1; ENSG00000204688.10.
DR Ensembl; ENST00000377133.6; ENSP00000366337.1; ENSG00000204688.10.
DR Ensembl; ENST00000377136.5; ENSP00000366340.1; ENSG00000204688.10.
DR Ensembl; ENST00000383550.3; ENSP00000373042.3; ENSG00000206471.10.
DR Ensembl; ENST00000383644.2; ENSP00000373140.2; ENSG00000206516.10.
DR Ensembl; ENST00000396792.2; ENSP00000380010.2; ENSG00000204688.10.
DR Ensembl; ENST00000400689.1; ENSP00000383527.1; ENSG00000206471.10.
DR Ensembl; ENST00000400693.6; ENSP00000383529.2; ENSG00000206471.10.
DR Ensembl; ENST00000400694.6; ENSP00000383530.2; ENSG00000206471.10.
DR Ensembl; ENST00000400712.1; ENSP00000383547.1; ENSG00000206516.10.
DR Ensembl; ENST00000400713.5; ENSP00000383548.1; ENSG00000206516.10.
DR Ensembl; ENST00000400714.5; ENSP00000383549.1; ENSG00000206516.10.
DR Ensembl; ENST00000412956.5; ENSP00000407739.1; ENSG00000232984.8.
DR Ensembl; ENST00000415581.1; ENSP00000396944.1; ENSG00000224395.8.
DR Ensembl; ENST00000416582.1; ENSP00000395850.1; ENSG00000229125.8.
DR Ensembl; ENST00000418376.1; ENSP00000395567.1; ENSG00000229408.8.
DR Ensembl; ENST00000421808.1; ENSP00000410401.1; ENSG00000232984.8.
DR Ensembl; ENST00000431658.1; ENSP00000394698.1; ENSG00000232984.8.
DR Ensembl; ENST00000435958.5; ENSP00000397171.1; ENSG00000224395.8.
DR Ensembl; ENST00000436167.5; ENSP00000388844.1; ENSG00000235132.8.
DR Ensembl; ENST00000438840.1; ENSP00000412463.1; ENSG00000224395.8.
DR Ensembl; ENST00000439879.5; ENSP00000409651.1; ENSG00000229408.8.
DR Ensembl; ENST00000440557.1; ENSP00000413910.1; ENSG00000229125.8.
DR Ensembl; ENST00000440672.1; ENSP00000396414.1; ENSG00000235132.8.
DR Ensembl; ENST00000443407.5; ENSP00000398695.1; ENSG00000232984.8.
DR Ensembl; ENST00000444920.1; ENSP00000410659.1; ENSG00000235132.8.
DR Ensembl; ENST00000446161.1; ENSP00000389230.1; ENSG00000229408.8.
DR Ensembl; ENST00000449826.5; ENSP00000411617.1; ENSG00000229408.8.
DR Ensembl; ENST00000453467.5; ENSP00000392619.1; ENSG00000229125.8.
DR Ensembl; ENST00000454071.5; ENSP00000395934.1; ENSG00000229125.8.
DR Ensembl; ENST00000456657.5; ENSP00000408584.1; ENSG00000235132.8.
DR Ensembl; ENST00000458051.5; ENSP00000405714.1; ENSG00000224395.8.
DR GeneID; 26716; -.
DR KEGG; hsa:26716; -.
DR MANE-Select; ENST00000377133.6; ENSP00000366337.1; NM_030883.5; NP_112145.1.
DR UCSC; uc003nmj.2; human.
DR CTD; 26716; -.
DR DisGeNET; 26716; -.
DR GeneCards; OR2H1; -.
DR HGNC; HGNC:8252; OR2H1.
DR HPA; ENSG00000204688; Tissue enriched (testis).
DR neXtProt; NX_Q9GZK4; -.
DR OpenTargets; ENSG00000204688; -.
DR PharmGKB; PA32161; -.
DR VEuPathDB; HostDB:ENSG00000204688; -.
DR eggNOG; ENOG502TAH4; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q9GZK4; -.
DR OMA; GTTECIF; -.
DR OrthoDB; 1017184at2759; -.
DR PhylomeDB; Q9GZK4; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q9GZK4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9GZK4; -.
DR BioGRID-ORCS; 26716; 11 hits in 665 CRISPR screens.
DR GeneWiki; OR2H1; -.
DR GenomeRNAi; 26716; -.
DR Pharos; Q9GZK4; Tdark.
DR PRO; PR:Q9GZK4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9GZK4; protein.
DR Bgee; ENSG00000204688; Expressed in right testis and 15 other tissues.
DR ExpressionAtlas; Q9GZK4; baseline and differential.
DR Genevisible; Q9GZK4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 2H1"
FT /id="PRO_0000150479"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 63
FT /note="D -> N (in allele 6M1-16*02; dbSNP:rs61732185)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_010944"
FT VARIANT 223
FT /note="V -> M (in dbSNP:rs17184086)"
FT /id="VAR_053143"
FT CONFLICT 158
FT /note="T -> K (in Ref. 8; AAC00188)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="R -> G (in Ref. 8; AAC00188)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="S -> Y (in Ref. 8; AAC00188)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 35339 MW; 19140A7FD690CF85 CRC64;
MVNQSSPMGF LLLGFSEHPA LERTLFVVVF TSYLLTLVGN TLIILLSVLY PRLHSPMYFF
LSDLSFLDLC FTTSCVPQML VNLWGPKKTI SFLGCSVQLF IFLSLGTTEC ILLTVMAFDR
YVAVCQPLHY ATIIHPRLCW QLASVAWVMS LVQSIVQTPS TLHLPFCPHQ QIDDFLCEVP
SLIRLSCGDT SYNEIQLAVS SVIFVVVPLS LILASYGATA QAVLRINSAT AWRKAFGTCS
SHLTVVTLFY SSVIAVYLQP KNPYAQGRGK FFGLFYAVGT PSLNPLVYTL RNKEIKRALR
RLLGKERDSR ESWRAA
