OR2H2_HUMAN
ID OR2H2_HUMAN Reviewed; 312 AA.
AC O95918; Q15062; Q2M1Y3; Q5STL8; Q5SUK1; Q6IFN7; Q6NTB7; Q96R14;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Olfactory receptor 2H2;
DE AltName: Full=Hs6M1-12;
DE AltName: Full=Olfactory receptor 2H3;
DE AltName: Full=Olfactory receptor-like protein FAT11;
GN Name=OR2H2; Synonyms=FAT11, OLFR2, OR2H3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-30.
RX PubMed=7665158; DOI=10.1006/geno.1995.1013;
RA Fan W., Liu Y.-C., Parimoo S., Weissman S.M.;
RT "Olfactory receptor-like genes are located in the human major
RT histocompatibility complex.";
RL Genomics 27:119-123(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-30; PHE-30; VAL-48 AND
RP ALA-220.
RX PubMed=10880742; DOI=10.1016/s0198-8859(00)00132-4;
RA Eklund A.C., Belchak M.M., Lapidos K., Raha-Chowdhury R., Ober C.;
RT "Polymorphisms in the HLA-linked olfactory receptor genes in the
RT Hutterites.";
RL Hum. Immunol. 61:711-717(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-30.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS PHE-30 AND
RP VAL-48.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-30.
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [8]
RP IDENTIFICATION, AND VARIANT VAL-48.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2H2";
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DR EMBL; L35475; AAB36567.1; -; Genomic_DNA.
DR EMBL; AF211939; AAF98751.1; -; Genomic_DNA.
DR EMBL; AF211940; AAF98752.1; -; Genomic_DNA.
DR EMBL; AF211941; AAF98753.1; -; Genomic_DNA.
DR EMBL; AF211942; AAF98754.1; -; Genomic_DNA.
DR EMBL; AB065965; BAC06177.1; -; Genomic_DNA.
DR EMBL; AL031983; CAA21455.1; -; Genomic_DNA.
DR EMBL; AL645936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX000688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR788300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03204.1; -; Genomic_DNA.
DR EMBL; BC069146; AAH69146.1; -; mRNA.
DR EMBL; BC101683; AAI01684.1; -; mRNA.
DR EMBL; BC112176; AAI12177.1; -; mRNA.
DR EMBL; AF399631; AAK95116.1; -; Genomic_DNA.
DR EMBL; BK004225; DAA04623.1; -; Genomic_DNA.
DR CCDS; CCDS34365.1; -.
DR PIR; A57069; A57069.
DR RefSeq; NP_009091.3; NM_007160.3.
DR AlphaFoldDB; O95918; -.
DR SMR; O95918; -.
DR BioGRID; 113659; 19.
DR STRING; 9606.ENSP00000373136; -.
DR GlyGen; O95918; 1 site.
DR iPTMnet; O95918; -.
DR PhosphoSitePlus; O95918; -.
DR BioMuta; OR2H2; -.
DR PaxDb; O95918; -.
DR PRIDE; O95918; -.
DR Antibodypedia; 50754; 108 antibodies from 20 providers.
DR DNASU; 7932; -.
DR Ensembl; ENST00000376947.6; ENSP00000366146.5; ENSG00000206512.6.
DR Ensembl; ENST00000383546.6; ENSP00000373038.5; ENSG00000206467.6.
DR Ensembl; ENST00000383640.4; ENSP00000373136.2; ENSG00000204657.4.
DR Ensembl; ENST00000411574.4; ENSP00000410227.3; ENSG00000229680.4.
DR Ensembl; ENST00000439874.4; ENSP00000403604.3; ENSG00000229185.4.
DR Ensembl; ENST00000453513.4; ENSP00000414688.3; ENSG00000224319.4.
DR Ensembl; ENST00000454628.4; ENSP00000409339.3; ENSG00000227044.4.
DR Ensembl; ENST00000641840.1; ENSP00000492959.1; ENSG00000204657.4.
DR GeneID; 7932; -.
DR KEGG; hsa:7932; -.
DR MANE-Select; ENST00000641840.1; ENSP00000492959.1; NM_007160.4; NP_009091.3.
DR UCSC; uc003nmr.2; human.
DR CTD; 7932; -.
DR DisGeNET; 7932; -.
DR GeneCards; OR2H2; -.
DR HGNC; HGNC:8253; OR2H2.
DR HPA; ENSG00000204657; Tissue enhanced (epididymis, testis).
DR MIM; 600578; gene.
DR neXtProt; NX_O95918; -.
DR OpenTargets; ENSG00000204657; -.
DR PharmGKB; PA32162; -.
DR VEuPathDB; HostDB:ENSG00000204657; -.
DR eggNOG; ENOG502TAH4; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; O95918; -.
DR OMA; QAMVNQS; -.
DR OrthoDB; 1017184at2759; -.
DR PhylomeDB; O95918; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; O95918; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 7932; 6 hits in 618 CRISPR screens.
DR GeneWiki; OR2H2; -.
DR GenomeRNAi; 7932; -.
DR Pharos; O95918; Tbio.
DR PRO; PR:O95918; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O95918; protein.
DR Bgee; ENSG00000204657; Expressed in putamen and 55 other tissues.
DR ExpressionAtlas; O95918; baseline and differential.
DR Genevisible; O95918; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; TAS:ProtInc.
DR GO; GO:0006952; P:defense response; TAS:ProtInc.
DR GO; GO:0007618; P:mating; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2H2"
FT /id="PRO_0000150480"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 30
FT /note="L -> F (in dbSNP:rs3129034)"
FT /evidence="ECO:0000269|PubMed:10880742,
FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.3"
FT /id="VAR_058087"
FT VARIANT 30
FT /note="L -> I (in dbSNP:rs3129034)"
FT /evidence="ECO:0000269|PubMed:7665158"
FT /id="VAR_023231"
FT VARIANT 30
FT /note="L -> S"
FT /evidence="ECO:0000269|PubMed:10880742"
FT /id="VAR_010227"
FT VARIANT 38
FT /note="V -> M (in dbSNP:rs11966382)"
FT /id="VAR_057540"
FT VARIANT 48
FT /note="A -> V (in dbSNP:rs1233387)"
FT /evidence="ECO:0000269|PubMed:10880742,
FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:14983052"
FT /id="VAR_010228"
FT VARIANT 220
FT /note="T -> A (in dbSNP:rs141430371)"
FT /evidence="ECO:0000269|PubMed:10880742"
FT /id="VAR_010229"
FT CONFLICT 2
FT /note="V -> D (in Ref. 1; AAB36567 and 6; AAH69146)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="E -> G (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="V -> D (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="P -> T (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="V -> A (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 113..114
FT /note="LT -> MK (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="E -> G (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 230..232
FT /note="KGR -> TAW (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="E -> G (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="I -> V (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 295..296
FT /note="VT -> IK (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 299
FT /note="F -> L (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
FT CONFLICT 307..312
FT /note="MGLTQS -> RDSRESWRAA (in Ref. 1; AAB36567)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34763 MW; 4E18B444768AAFC5 CRC64;
MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD PKLHSPMYFF
LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF IFLSLGTTEC ILLTVMAFDR
YVAVCQPLHY ATIIHPRLCW QLASVAWVIG LVESVVQTPS TLHLPFCPDR QVDDFVCEVP
ALIRLSCEDT SYNEIQVAVA SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS
SHLTVVTLFY SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR
RLLGKEMGLT QS
