ID   OR2I1_HUMAN             Reviewed;         316 AA.
AC   Q8NGU4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Putative olfactory receptor 2I1;
DE   AltName: Full=Putative olfactory receptor 2I2;
DE   AltName: Full=Putative olfactory receptor 2I3;
DE   AltName: Full=Putative olfactory receptor 2I4;
GN   Name=OR2I1P; Synonyms=OR2I2, OR2I3P, OR2I4P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2I1P";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065686; BAC05909.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8NGU4; -.
DR   SMR; Q8NGU4; -.
DR   iPTMnet; Q8NGU4; -.
DR   PhosphoSitePlus; Q8NGU4; -.
DR   BioMuta; HGNC:8258; -.
DR   DMDM; 38372773; -.
DR   PeptideAtlas; Q8NGU4; -.
DR   PRIDE; Q8NGU4; -.
DR   ProteomicsDB; 73605; -.
DR   GeneCards; OR2I1P; -.
DR   HGNC; HGNC:8258; OR2I1P.
DR   neXtProt; NX_Q8NGU4; -.
DR   InParanoid; Q8NGU4; -.
DR   PhylomeDB; Q8NGU4; -.
DR   PathwayCommons; Q8NGU4; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   Pharos; Q8NGU4; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8NGU4; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   5: Uncertain;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Putative olfactory receptor 2I1"
FT                   /id="PRO_0000150481"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..273
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   316 AA;  34115 MW;  D2F4130366039DC7 CRC64;
     MLANQASAEE RFLLLGFSDW PSLQPVLFAL VLLCYLLTLT GNSALVLLAV RDPRLHTPMY
     YFLCHLALVD AGFTTSVVPP LLANLRGPAL WLPRSHCTAQ LCASLALGSA ECVLLAVMAL
     DRAAAVCRPL RYAGLVSPRL CRTLASASWL SGLTNSVAQT ALLAERPLCA PRLLDHFICE
     LPALLKLACG GDGDTTENQM FAARVVILLL PFAVILASYG AVARAVCCMR FSGGRRRAVG
     TCGSHLTAVC LFYGSAIYTY LQPAQRYNQA RGKFVSLFYT VVTPALNPLI YTLRNKKVKG
     AARRLLRSLG RGQAGQ