OR2J1_HUMAN
ID OR2J1_HUMAN Reviewed; 312 AA.
AC Q9GZK6; A2AAS1; B0V1T2; Q9GZK1;
DT 21-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 2J1;
DE AltName: Full=Hs6M1-4;
DE AltName: Full=Olfactory receptor 6-5;
DE Short=OR6-5;
GN Name=OR2J1; Synonyms=OR2J1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-14.
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-14.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon in the gene coding for this protein at
CC position Gln-194 is responsible for functional diversity thus producing
CC a pseudogene. The stop codon is more frequent in non-Africans than in
CC African-Americans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2J1";
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DR EMBL; AJ302565; CAC20485.1; -; Genomic_DNA.
DR EMBL; AJ302566; CAC20486.1; -; Genomic_DNA.
DR EMBL; AJ302567; CAC20487.1; -; Genomic_DNA.
DR EMBL; AJ302568; CAC20488.1; -; Genomic_DNA.
DR EMBL; AJ302569; CAC20489.1; -; Genomic_DNA.
DR EMBL; AJ302570; CAC20490.1; -; Genomic_DNA.
DR EMBL; AL645937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR933783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS87377.1; -.
DR RefSeq; NP_001335223.1; NM_001348294.1.
DR AlphaFoldDB; Q9GZK6; -.
DR SMR; Q9GZK6; -.
DR GlyGen; Q9GZK6; 1 site.
DR BioMuta; OR2J1; -.
DR DMDM; 147744582; -.
DR PaxDb; Q9GZK6; -.
DR PeptideAtlas; Q9GZK6; -.
DR PRIDE; Q9GZK6; -.
DR Antibodypedia; 82189; 2 antibodies from 2 providers.
DR DNASU; 442185; -.
DR Ensembl; ENST00000377171.3; ENSP00000366376.3; ENSG00000204702.6.
DR Ensembl; ENST00000427659.2; ENSP00000414527.2; ENSG00000226931.2.
DR Ensembl; ENST00000641659.2; ENSP00000493312.1; ENSG00000204702.6.
DR GeneID; 442185; -.
DR KEGG; hsa:442185; -.
DR MANE-Select; ENST00000641659.2; ENSP00000493312.1; NM_001348294.2; NP_001335223.1.
DR UCSC; uc063mmp.1; human.
DR CTD; 442185; -.
DR GeneCards; OR2J1; -.
DR HGNC; HGNC:8259; OR2J1.
DR HPA; ENSG00000204702; Not detected.
DR neXtProt; NX_Q9GZK6; -.
DR VEuPathDB; HostDB:ENSG00000204702; -.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q9GZK6; -.
DR OMA; MGWEWGI; -.
DR OrthoDB; 954090at2759; -.
DR PhylomeDB; Q9GZK6; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q9GZK6; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 442185; 1 hit in 36 CRISPR screens.
DR GenomeRNAi; 442185; -.
DR Pharos; Q9GZK6; Tdark.
DR PRO; PR:Q9GZK6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9GZK6; protein.
DR Genevisible; Q9GZK6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2J1"
FT /id="PRO_0000150482"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 14
FT /note="L -> I (in dbSNP:rs3131087)"
FT /evidence="ECO:0000269|PubMed:14574404, ECO:0000269|Ref.1"
FT /id="VAR_019066"
SQ SEQUENCE 312 AA; 35454 MW; 8AD0748A7CCE4FFC CRC64;
MLMKKNASFE DFFLLLGFSN WPHLEVVLFV VILIFYLITL IGNLFIIILS YLDSHLHTPM
YFFLSNLSFL DLCYTTSSIP QLLVNLWGPE KTISYAGCTV QLYFVLALGT AECVLLVVMS
YDRYAAVCRP LHYTVLMHPR FCRLLAAASW VSGFTTSALH SSFTFWIPLC RHRLVDHFFC
EVPALLRLSC VDTQANELTL MVMSSIFVLI PLILILTSYG AIARAVLSMQ STTGLQKVLR
TCGAHLMVVS LFFIPVMCMY LQPPSENSQD QGKFIALFYT VVTPSLNPLI YTFRNKDVRG
AVKRLMGWEW GM
