OR2J2_HUMAN
ID OR2J2_HUMAN Reviewed; 312 AA.
AC O76002; A6NCU9; A6NLD0; B0UY53; Q32N09; Q5ST39; Q5SUJ6; Q6IF24; Q9GZK2;
AC Q9GZL3;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Olfactory receptor 2J2;
DE AltName: Full=Hs6M1-6;
DE AltName: Full=Olfactory receptor 6-8;
DE Short=OR6-8;
DE AltName: Full=Olfactory receptor OR6-19;
GN Name=OR2J2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS TYR-74; THR-111; VAL-146
RP AND THR-218.
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS TYR-74;
RP THR-111; VAL-146 AND THR-218.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS TYR-74; VAL-146 AND
RP THR-218.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: Three OR2J2 alleles are known: 6M1-6*01, 6M1-6*02 and
CC 6M1-6*03. The sequence shown is that of allele 6M1-6*01.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2J2";
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DR EMBL; AJ302571; CAC20491.1; -; Genomic_DNA.
DR EMBL; AJ302572; CAC20492.1; -; Genomic_DNA.
DR EMBL; AJ302573; CAC20493.1; -; Genomic_DNA.
DR EMBL; AJ302574; CAC20494.1; -; Genomic_DNA.
DR EMBL; AJ302575; CAC20495.1; -; Genomic_DNA.
DR EMBL; AJ302576; CAC20496.1; -; Genomic_DNA.
DR EMBL; AJ302577; CAC20497.1; -; Genomic_DNA.
DR EMBL; AJ302578; CAC20498.1; -; Genomic_DNA.
DR EMBL; AJ302579; CAC20499.1; -; Genomic_DNA.
DR EMBL; AJ302580; CAC20500.1; -; Genomic_DNA.
DR EMBL; AJ302581; CAC20501.1; -; Genomic_DNA.
DR EMBL; AJ302582; CAC20502.1; -; Genomic_DNA.
DR EMBL; AJ302583; CAC20503.1; -; Genomic_DNA.
DR EMBL; CR388415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL022727; CAA18784.1; -; Genomic_DNA.
DR EMBL; BX248093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069121; AAH69121.1; -; mRNA.
DR EMBL; BC108896; AAI08897.1; -; mRNA.
DR EMBL; BC108897; AAI08898.1; -; mRNA.
DR EMBL; BC108898; AAI08899.1; -; mRNA.
DR EMBL; BC108899; AAI08900.1; -; mRNA.
DR EMBL; BK004438; DAA04836.1; -; Genomic_DNA.
DR CCDS; CCDS43434.1; -.
DR RefSeq; NP_112167.2; NM_030905.2.
DR AlphaFoldDB; O76002; -.
DR SMR; O76002; -.
DR STRING; 9606.ENSP00000366372; -.
DR GlyGen; O76002; 1 site.
DR BioMuta; OR2J2; -.
DR MassIVE; O76002; -.
DR PaxDb; O76002; -.
DR PeptideAtlas; O76002; -.
DR PRIDE; O76002; -.
DR Antibodypedia; 57668; 61 antibodies from 17 providers.
DR DNASU; 26707; -.
DR Ensembl; ENST00000358688.7; ENSP00000351519.6; ENSG00000196231.7.
DR Ensembl; ENST00000377167.3; ENSP00000366372.2; ENSG00000204700.5.
DR Ensembl; ENST00000411588.4; ENSP00000396524.3; ENSG00000231676.4.
DR Ensembl; ENST00000415857.3; ENSP00000392497.2; ENSG00000226000.4.
DR Ensembl; ENST00000419605.3; ENSP00000408988.2; ENSG00000232945.4.
DR Ensembl; ENST00000427744.3; ENSP00000403186.2; ENSG00000234746.4.
DR Ensembl; ENST00000440124.4; ENSP00000398238.3; ENSG00000225550.4.
DR Ensembl; ENST00000457762.3; ENSP00000416299.2; ENSG00000226347.4.
DR GeneID; 26707; -.
DR KEGG; hsa:26707; -.
DR UCSC; uc011dlm.3; human.
DR CTD; 26707; -.
DR GeneCards; OR2J2; -.
DR HGNC; HGNC:8260; OR2J2.
DR HPA; ENSG00000204700; Not detected.
DR neXtProt; NX_O76002; -.
DR PharmGKB; PA32177; -.
DR VEuPathDB; HostDB:ENSG00000204700; -.
DR eggNOG; ENOG502RU1S; Eukaryota.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; O76002; -.
DR OrthoDB; 954090at2759; -.
DR PhylomeDB; O76002; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; O76002; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26707; 11 hits in 585 CRISPR screens.
DR GeneWiki; OR2J2; -.
DR GenomeRNAi; 26707; -.
DR Pharos; O76002; Tdark.
DR PRO; PR:O76002; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O76002; protein.
DR Bgee; ENSG00000204700; Expressed in fallopian tube and 7 other tissues.
DR ExpressionAtlas; O76002; baseline and differential.
DR Genevisible; O76002; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2J2"
FT /id="PRO_0000150483"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 74
FT /note="H -> Y (in allele 6M1-6*02 and allele 6M1-6*03;
FT dbSNP:rs3116855)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_010945"
FT VARIANT 111
FT /note="A -> T (in allele 6M1-6*03; dbSNP:rs3129157)"
FT /evidence="ECO:0000269|PubMed:14574404, ECO:0000269|Ref.1"
FT /id="VAR_010946"
FT VARIANT 146
FT /note="A -> V (in allele 6M1-6*02 and allele 6M1-6*03;
FT dbSNP:rs3116856)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_010947"
FT VARIANT 218
FT /note="A -> T (in allele 6M1-6*02 and allele 6M1-6*03;
FT dbSNP:rs3130743)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_010948"
FT CONFLICT 26
FT /note="V -> A (in Ref. 3; AAI08897)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35204 MW; FB7D20BB2379C43E CRC64;
MMIKKNASSE DFFILLGFSN WPQLEVVLFV VILIFYLMTL TGNLFIIILS YVDSHLHTPM
YFFLSNLSFL DLCHTTSSIP QLLVNLRGPE KTISYAGCMV QLYFVLALGI AECVLLVVMS
YDRYVAVCRP LHYTVLMHPR FCHLLAAASW VIGFTISALH SSFTFWVPLC GHRLVDHFFC
EVPALLRLSC VDTHANELTL MVMSSIFVLI PLILILTAYG AIARAVLSMQ STTGLQKVFR
TCGAHLMVVS LFFIPVMCMY LQPPSENSPD QGKFIALFYT VVTPSLNPLI YTLRNKHVKG
AAKRLLGWEW GK
