OR2K2_HUMAN
ID OR2K2_HUMAN Reviewed; 316 AA.
AC Q8NGT1; Q2TA61; Q5VYK4; Q6IFI5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 2K2;
DE AltName: Full=HTPCRH06;
DE AltName: Full=Olfactory receptor OR9-17;
GN Name=OR2K2; Synonyms=OR2AR1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04675.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2K2";
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DR EMBL; AB065707; BAC05929.1; -; Genomic_DNA.
DR EMBL; AL354661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111086; AAI11087.1; -; mRNA.
DR EMBL; BK004277; DAA04675.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS6778.1; -.
DR RefSeq; NP_995581.1; NM_205859.1.
DR RefSeq; XP_011516822.1; XM_011518520.2.
DR AlphaFoldDB; Q8NGT1; -.
DR SMR; Q8NGT1; -.
DR BioGRID; 117636; 9.
DR IntAct; Q8NGT1; 2.
DR STRING; 9606.ENSP00000305055; -.
DR GlyGen; Q8NGT1; 1 site.
DR iPTMnet; Q8NGT1; -.
DR PhosphoSitePlus; Q8NGT1; -.
DR BioMuta; OR2K2; -.
DR DMDM; 218511729; -.
DR MassIVE; Q8NGT1; -.
DR PaxDb; Q8NGT1; -.
DR PeptideAtlas; Q8NGT1; -.
DR PRIDE; Q8NGT1; -.
DR Antibodypedia; 15116; 113 antibodies from 22 providers.
DR DNASU; 26248; -.
DR Ensembl; ENST00000302681.3; ENSP00000305055.1; ENSG00000171133.4.
DR GeneID; 26248; -.
DR KEGG; hsa:26248; -.
DR MANE-Select; ENST00000302681.3; ENSP00000305055.1; NM_205859.2; NP_995581.1.
DR UCSC; uc011lwp.2; human.
DR CTD; 26248; -.
DR GeneCards; OR2K2; -.
DR HGNC; HGNC:8264; OR2K2.
DR HPA; ENSG00000171133; Not detected.
DR neXtProt; NX_Q8NGT1; -.
DR OpenTargets; ENSG00000171133; -.
DR PharmGKB; PA32181; -.
DR VEuPathDB; HostDB:ENSG00000171133; -.
DR eggNOG; ENOG502R18M; Eukaryota.
DR GeneTree; ENSGT01040000240406; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGT1; -.
DR OrthoDB; 995809at2759; -.
DR PhylomeDB; Q8NGT1; -.
DR TreeFam; TF352686; -.
DR PathwayCommons; Q8NGT1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGT1; -.
DR BioGRID-ORCS; 26248; 5 hits in 653 CRISPR screens.
DR GeneWiki; OR2K2; -.
DR GenomeRNAi; 26248; -.
DR Pharos; Q8NGT1; Tdark.
DR PRO; PR:Q8NGT1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8NGT1; protein.
DR Bgee; ENSG00000171133; Expressed in C1 segment of cervical spinal cord and 20 other tissues.
DR ExpressionAtlas; Q8NGT1; baseline and differential.
DR Genevisible; Q8NGT1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 2K2"
FT /id="PRO_0000150485"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 316 AA; 35045 MW; BA48E3C2E6DF7A79 CRC64;
MQGENFTIWS IFFLEGFSQY PGLEVVLFVF SLVMYLTTLL GNSTLILITI LDSRLKTPMY
LFLGNLSFMD ICYTSASVPT LLVNLLSSQK TIIFSGCAVQ MYLSLAMGST ECVLLAVMAY
DRYVAICNPL RYSIIMNRCV CARMATVSWV TGCLTALLET SFALQIPLCG NLIDHFTCEI
LAVLKLACTS SLLMNTIMLV VSILLLPIPM LLVCISYIFI LSTILRITSA EGRNKAFSTC
GAHLTVVILY YGAALSMYLK PSSSNAQKID KIISLLYGVL TPMLNPIIYS LRNKEVKDAM
KKLLGKITLH QTHEHL
