OR2L2_HUMAN
ID OR2L2_HUMAN Reviewed; 312 AA.
AC Q8NH16; Q2M3T5;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Olfactory receptor 2L2;
DE AltName: Full=HTPCRH07;
DE AltName: Full=Olfactory receptor 2L12;
DE AltName: Full=Olfactory receptor 2L4;
GN Name=OR2L2; Synonyms=OR2L12, OR2L4P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 125-238.
RC TISSUE=Testis;
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L2";
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DR EMBL; AB065597; BAC05825.1; -; Genomic_DNA.
DR EMBL; BC104792; AAI04793.1; -; mRNA.
DR EMBL; BC104794; AAI04795.1; -; mRNA.
DR EMBL; X64978; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS31103.1; -.
DR RefSeq; NP_001004686.1; NM_001004686.2.
DR RefSeq; XP_011542460.1; XM_011544158.2.
DR AlphaFoldDB; Q8NH16; -.
DR SMR; Q8NH16; -.
DR BioGRID; 117634; 14.
DR STRING; 9606.ENSP00000355435; -.
DR GlyGen; Q8NH16; 2 sites.
DR iPTMnet; Q8NH16; -.
DR PhosphoSitePlus; Q8NH16; -.
DR BioMuta; OR2L2; -.
DR DMDM; 38258181; -.
DR MassIVE; Q8NH16; -.
DR PaxDb; Q8NH16; -.
DR PRIDE; Q8NH16; -.
DR Antibodypedia; 54364; 23 antibodies from 13 providers.
DR DNASU; 26246; -.
DR Ensembl; ENST00000366479.4; ENSP00000355435.2; ENSG00000203663.4.
DR Ensembl; ENST00000641771.1; ENSP00000493410.1; ENSG00000203663.4.
DR Ensembl; ENST00000642011.1; ENSP00000493154.1; ENSG00000203663.4.
DR GeneID; 26246; -.
DR KEGG; hsa:26246; -.
DR MANE-Select; ENST00000641771.1; ENSP00000493410.1; NM_001385855.1; NP_001372784.1.
DR UCSC; uc001idw.4; human.
DR CTD; 26246; -.
DR GeneCards; OR2L2; -.
DR HGNC; HGNC:8266; OR2L2.
DR HPA; ENSG00000203663; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q8NH16; -.
DR OpenTargets; ENSG00000203663; -.
DR PharmGKB; PA32183; -.
DR VEuPathDB; HostDB:ENSG00000203663; -.
DR eggNOG; ENOG502RTYI; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH16; -.
DR OMA; RMCSIKI; -.
DR OrthoDB; 950954at2759; -.
DR PhylomeDB; Q8NH16; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NH16; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26246; 8 hits in 637 CRISPR screens.
DR GeneWiki; OR2L2; -.
DR GenomeRNAi; 26246; -.
DR Pharos; Q8NH16; Tdark.
DR PRO; PR:Q8NH16; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NH16; protein.
DR Bgee; ENSG00000203663; Expressed in C1 segment of cervical spinal cord and 25 other tissues.
DR ExpressionAtlas; Q8NH16; baseline and differential.
DR Genevisible; Q8NH16; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2L2"
FT /id="PRO_0000150486"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 249
FT /note="F -> L (in dbSNP:rs12134979)"
FT /id="VAR_053144"
FT VARIANT 259
FT /note="V -> L (in dbSNP:rs6658141)"
FT /id="VAR_053145"
SQ SEQUENCE 312 AA; 35495 MW; C85F0368D685C1DE CRC64;
MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL DIHLHTPMYF
LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS FFFLTLAVAE GLLLTSMAYD
RYVAICFPLH YPIRISKRVC VMMITGSWMI SSINSCAHTV YALCIPYCKS RAINHFFCDV
PAMLTLACTD TWVYESTVFL SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC
STHLTVVSFY YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL
TQVIQKIFSV KM
