OR2L3_HUMAN
ID OR2L3_HUMAN Reviewed; 312 AA.
AC Q8NG85; B9EH44;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 2L3;
GN Name=OR2L3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L3";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065950; BAC06163.1; -; Genomic_DNA.
DR EMBL; CH471148; EAW77215.1; -; Genomic_DNA.
DR EMBL; BC137039; AAI37040.1; -; mRNA.
DR EMBL; BC137040; AAI37041.1; -; mRNA.
DR CCDS; CCDS31104.1; -.
DR RefSeq; NP_001004687.1; NM_001004687.1.
DR AlphaFoldDB; Q8NG85; -.
DR SMR; Q8NG85; -.
DR STRING; 9606.ENSP00000353044; -.
DR GlyGen; Q8NG85; 2 sites.
DR iPTMnet; Q8NG85; -.
DR PhosphoSitePlus; Q8NG85; -.
DR BioMuta; OR2L3; -.
DR DMDM; 74762575; -.
DR MassIVE; Q8NG85; -.
DR PaxDb; Q8NG85; -.
DR PeptideAtlas; Q8NG85; -.
DR PRIDE; Q8NG85; -.
DR Antibodypedia; 34744; 27 antibodies from 12 providers.
DR DNASU; 391192; -.
DR Ensembl; ENST00000359959.4; ENSP00000353044.3; ENSG00000198128.4.
DR Ensembl; ENST00000641161.1; ENSP00000493424.1; ENSG00000198128.4.
DR Ensembl; ENST00000641649.1; ENSP00000493020.1; ENSG00000198128.4.
DR GeneID; 391192; -.
DR KEGG; hsa:391192; -.
DR MANE-Select; ENST00000359959.4; ENSP00000353044.3; NM_001004687.2; NP_001004687.1.
DR UCSC; uc001idx.1; human.
DR CTD; 391192; -.
DR GeneCards; OR2L3; -.
DR HGNC; HGNC:15009; OR2L3.
DR HPA; ENSG00000198128; Not detected.
DR neXtProt; NX_Q8NG85; -.
DR OpenTargets; ENSG00000198128; -.
DR PharmGKB; PA32184; -.
DR VEuPathDB; HostDB:ENSG00000198128; -.
DR eggNOG; ENOG502RTYI; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG85; -.
DR OMA; MENCNQT; -.
DR OrthoDB; 950954at2759; -.
DR PhylomeDB; Q8NG85; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NG85; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391192; 4 hits in 596 CRISPR screens.
DR GenomeRNAi; 391192; -.
DR Pharos; Q8NG85; Tdark.
DR PRO; PR:Q8NG85; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NG85; protein.
DR Bgee; ENSG00000198128; Expressed in cortical plate and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2L3"
FT /id="PRO_0000150487"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 39
FT /note="I -> T (in dbSNP:rs6666048)"
FT /id="VAR_062021"
FT VARIANT 78
FT /note="P -> L (in dbSNP:rs6658227)"
FT /id="VAR_062022"
FT VARIANT 104
FT /note="S -> L (in dbSNP:rs6658256)"
FT /id="VAR_053146"
FT VARIANT 139
FT /note="M -> V (in dbSNP:rs55937620)"
FT /id="VAR_062023"
SQ SEQUENCE 312 AA; 35282 MW; F1E30E85789A738E CRC64;
MENYNQTSTD FILLGFFPPS RIGLFLFILI VFIFLMALIG NLSMILLIFL DTHLHTPMYF
LLSQLSLIDL NYISTIVPKM ASDFLSGNKS ISFTGCGIQS FFFSALGGAE ALLLASMAYD
RYIAICFPLH YPIRMSKRMC VLMITGSWII GSINACAHTV YVLHIPYCQS RAINHFFCDV
PAMVTLACMD TWVYEGTVFL STTIFLVFPF IAISCSYGRV LLAVYHMKSA EGRKKAYLTC
STHLTVVTFY YAPFVYTYLR PRSLRSPTED KVLAVFYTTL TPMLNPIIYS LRNKEVMGAL
TRVSQRICSG KM
