OR2L5_HUMAN
ID OR2L5_HUMAN Reviewed; 312 AA.
AC Q8NG80; Q6IF04;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 2L5;
DE AltName: Full=Olfactory receptor 2L11;
DE AltName: Full=Olfactory receptor OR1-53;
GN Name=OR2L5; Synonyms=OR2L11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L5";
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DR EMBL; AB065956; BAC06169.1; -; Genomic_DNA.
DR EMBL; BK004458; DAA04856.1; -; Genomic_DNA.
DR CCDS; CCDS58068.1; -.
DR RefSeq; NP_001245213.1; NM_001258284.1.
DR AlphaFoldDB; Q8NG80; -.
DR SMR; Q8NG80; -.
DR BioGRID; 123489; 1.
DR STRING; 9606.ENSP00000347428; -.
DR GlyGen; Q8NG80; 1 site.
DR BioMuta; OR2L5; -.
DR DMDM; 38372496; -.
DR MassIVE; Q8NG80; -.
DR PaxDb; Q8NG80; -.
DR PRIDE; Q8NG80; -.
DR Antibodypedia; 64186; 37 antibodies from 14 providers.
DR DNASU; 81466; -.
DR Ensembl; ENST00000355281.2; ENSP00000347428.1; ENSG00000197454.2.
DR GeneID; 81466; -.
DR KEGG; hsa:81466; -.
DR MANE-Select; ENST00000355281.2; ENSP00000347428.1; NM_001258284.2; NP_001245213.1.
DR UCSC; uc031psy.1; human.
DR CTD; 81466; -.
DR GeneCards; OR2L5; -.
DR HGNC; HGNC:15011; OR2L5.
DR HPA; ENSG00000197454; Not detected.
DR neXtProt; NX_Q8NG80; -.
DR OpenTargets; ENSG00000197454; -.
DR VEuPathDB; HostDB:ENSG00000197454; -.
DR eggNOG; ENOG502RTYI; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG80; -.
DR OMA; MTFAGAE; -.
DR OrthoDB; 950954at2759; -.
DR PhylomeDB; Q8NG80; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NG80; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81466; 11 hits in 624 CRISPR screens.
DR GenomeRNAi; 81466; -.
DR Pharos; Q8NG80; Tdark.
DR PRO; PR:Q8NG80; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NG80; protein.
DR Bgee; ENSG00000197454; Expressed in reproductive system and 2 other tissues.
DR ExpressionAtlas; Q8NG80; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2L5"
FT /id="PRO_0000150488"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 35648 MW; E04FEB775A902863 CRC64;
MENYNQTSTD FILLGLFPPS KIGLFLFILF VLIFLMALIG NLSMILLIFL DTHLHTPMYF
LLSQLSLIDL NYISTIVPKM ASDFLYGNKS ISFIGCGIQS FFFMTFAGAE ALLLTSMAYD
RYVAICFPLH YPIRMSKRMY VLMITGSWMI GSINSCAHTV YAFRIPYCKS RAINHFFCDV
PAMLTLACTD TWVYEYTVFL SSTIFLVFPF TGIACSYGWV LLAVYRMHSA EGRKKAYSTC
STHLTVVTFY YAPFAYTYLC PRSLRSLTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
TRVIQNIFSV KM
