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OR2L8_HUMAN
ID   OR2L8_HUMAN             Reviewed;         312 AA.
AC   Q8NGY9; B9EIN6; Q6IF03;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Olfactory receptor 2L8;
DE   AltName: Full=Olfactory receptor OR1-46;
GN   Name=OR2L8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-294 AND LYS-301.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L8";
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DR   EMBL; AB065627; BAC05853.1; -; Genomic_DNA.
DR   EMBL; BC140751; AAI40752.1; -; mRNA.
DR   EMBL; BK004459; DAA04857.1; -; Genomic_DNA.
DR   RefSeq; NP_001001963.1; NM_001001963.1.
DR   AlphaFoldDB; Q8NGY9; -.
DR   SMR; Q8NGY9; -.
DR   STRING; 9606.ENSP00000349719; -.
DR   GlyGen; Q8NGY9; 2 sites.
DR   BioMuta; OR2L8; -.
DR   DMDM; 38372791; -.
DR   MassIVE; Q8NGY9; -.
DR   PaxDb; Q8NGY9; -.
DR   PRIDE; Q8NGY9; -.
DR   Antibodypedia; 79198; 72 antibodies from 15 providers.
DR   DNASU; 391190; -.
DR   Ensembl; ENST00000623922.1; ENSP00000485287.1; ENSG00000279263.1.
DR   GeneID; 391190; -.
DR   KEGG; hsa:391190; -.
DR   MANE-Select; ENST00000623922.1; ENSP00000485287.1; NM_001001963.1; NP_001001963.1.
DR   UCSC; uc001idt.1; human.
DR   CTD; 391190; -.
DR   GeneCards; OR2L8; -.
DR   HGNC; HGNC:15014; OR2L8.
DR   HPA; ENSG00000279263; Tissue enriched (brain).
DR   neXtProt; NX_Q8NGY9; -.
DR   PharmGKB; PA32189; -.
DR   VEuPathDB; HostDB:ENSG00000279263; -.
DR   eggNOG; ENOG502RTYI; Eukaryota.
DR   GeneTree; ENSGT01050000244880; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NGY9; -.
DR   OMA; LPFTCIV; -.
DR   OrthoDB; 950954at2759; -.
DR   PhylomeDB; Q8NGY9; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q8NGY9; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 391190; 10 hits in 578 CRISPR screens.
DR   GeneWiki; OR2L8; -.
DR   GenomeRNAi; 391190; -.
DR   Pharos; Q8NGY9; Tdark.
DR   PRO; PR:Q8NGY9; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NGY9; protein.
DR   Bgee; ENSG00000279263; Expressed in adrenal tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 2L8"
FT                   /id="PRO_0000150489"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..48
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..157
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..194
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         196
FT                   /note="G -> C (in dbSNP:rs4925788)"
FT                   /id="VAR_059987"
FT   VARIANT         202
FT                   /note="A -> T (in dbSNP:rs4925790)"
FT                   /id="VAR_059988"
FT   VARIANT         217
FT                   /note="Y -> C (in dbSNP:rs4925583)"
FT                   /id="VAR_053147"
FT   VARIANT         226
FT                   /note="H -> R (in dbSNP:rs4925792)"
FT                   /id="VAR_062024"
FT   VARIANT         294
FT                   /note="K -> R (in dbSNP:rs10888282)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_059989"
FT   VARIANT         301
FT                   /note="T -> K (in dbSNP:rs74155337)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_080452"
SQ   SEQUENCE   312 AA;  35444 MW;  845325F98685A4D4 CRC64;
     MENYNQTSTD FILLGLFPPS RIDLFFFILI VFIFLMALIG NLSMILLIFL DTHLHTPMYF
     LLSQLSLIDL NYISTIVPKM ASDFLHGNKS ISFTGCGIQS FFFLALGGAE ALLLASMAYD
     RYIAICFPLH YLIRMSKRVC VLMITGSWII GSINACAHTV YVLHIPYCRS RAINHFFCDV
     PAMVTLACMD TWVYEGTVFL SATIFLVFPF IGISCSYGQV LFAVYHMKSA EGRKKAYLTC
     STHLTVVTFY YAPFVYTYLR PRSLRSPTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
     TRVSQRICSV KM
 
 
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