OR2LD_HUMAN
ID OR2LD_HUMAN Reviewed; 312 AA.
AC Q8N349; Q5VUR5;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 2L13;
DE AltName: Full=Olfactory receptor 2L14;
GN Name=OR2L13; Synonyms=OR2L14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2L13";
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DR EMBL; AL513488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028158; AAH28158.1; -; mRNA.
DR CCDS; CCDS1637.1; -.
DR RefSeq; NP_001291464.1; NM_001304535.1.
DR RefSeq; NP_787107.1; NM_175911.3.
DR RefSeq; XP_011542471.1; XM_011544169.2.
DR AlphaFoldDB; Q8N349; -.
DR SMR; Q8N349; -.
DR BioGRID; 129891; 7.
DR STRING; 9606.ENSP00000355434; -.
DR GlyGen; Q8N349; 2 sites.
DR PhosphoSitePlus; Q8N349; -.
DR BioMuta; OR2L13; -.
DR DMDM; 38372494; -.
DR MassIVE; Q8N349; -.
DR PaxDb; Q8N349; -.
DR PeptideAtlas; Q8N349; -.
DR PRIDE; Q8N349; -.
DR ProteomicsDB; 71763; -.
DR Antibodypedia; 65612; 95 antibodies from 20 providers.
DR DNASU; 284521; -.
DR Ensembl; ENST00000358120.3; ENSP00000350836.2; ENSG00000196071.5.
DR Ensembl; ENST00000641714.1; ENSP00000493075.1; ENSG00000196071.5.
DR Ensembl; ENST00000641893.1; ENSP00000492949.1; ENSG00000196071.5.
DR GeneID; 284521; -.
DR KEGG; hsa:284521; -.
DR MANE-Select; ENST00000358120.4; ENSP00000350836.2; NM_001395936.1; NP_001382865.1.
DR UCSC; uc001ids.4; human.
DR CTD; 284521; -.
DR DisGeNET; 284521; -.
DR GeneCards; OR2L13; -.
DR HGNC; HGNC:19578; OR2L13.
DR HPA; ENSG00000196071; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q8N349; -.
DR OpenTargets; ENSG00000196071; -.
DR PharmGKB; PA134982185; -.
DR VEuPathDB; HostDB:ENSG00000196071; -.
DR eggNOG; ENOG502RTYI; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8N349; -.
DR OMA; NMAFNFF; -.
DR OrthoDB; 909874at2759; -.
DR PhylomeDB; Q8N349; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8N349; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 284521; 5 hits in 671 CRISPR screens.
DR ChiTaRS; OR2L13; human.
DR GeneWiki; OR2L13; -.
DR GenomeRNAi; 284521; -.
DR Pharos; Q8N349; Tdark.
DR PRO; PR:Q8N349; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N349; protein.
DR Bgee; ENSG00000196071; Expressed in prefrontal cortex and 52 other tissues.
DR ExpressionAtlas; Q8N349; baseline and differential.
DR Genevisible; Q8N349; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR030781; OR2L13.
DR PANTHER; PTHR26453:SF102; PTHR26453:SF102; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2L13"
FT /id="PRO_0000150490"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 156
FT /note="L -> F (in dbSNP:rs12742561)"
FT /id="VAR_053148"
FT VARIANT 265
FT /note="R -> H (in dbSNP:rs45577033)"
FT /id="VAR_062025"
SQ SEQUENCE 312 AA; 35634 MW; 85AFE1D772F2A905 CRC64;
MEKWNHTSND FILLGLLPPN QTGIFLLCLI ILIFFLASVG NSAMIHLIHV DPRLHTPMYF
LLSQLSLMDL MYISTTVPKM AYNFLSGQKG ISFLGCGVQS FFFLTMACSE GLLLTSMAYD
RYLAICHSLY YPIRMSKMMC VKMIGGSWTL GSINSLAHTV FALHIPYCRS RAIDHFFCDV
PAMLLLACTD TWVYEYMVFV STSLFLLFPF IGITSSCGRV LFAVYHMHSK EGRKKAFTTI
STHLTVVIFY YAPFVYTYLR PRNLRSPAED KILAVFYTIL TPMLNPIIYS LRNKEVLGAM
RRVFGIFSFL KE
