OR2M2_HUMAN
ID OR2M2_HUMAN Reviewed; 347 AA.
AC Q96R28; A3KFT4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 2M2;
DE AltName: Full=OST423;
GN Name=OR2M2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2M2";
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DR EMBL; AL592313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399616; AAK95101.1; -; Genomic_DNA.
DR CCDS; CCDS31106.1; -.
DR RefSeq; NP_001004688.1; NM_001004688.1.
DR AlphaFoldDB; Q96R28; -.
DR SMR; Q96R28; -.
DR STRING; 9606.ENSP00000352710; -.
DR GlyGen; Q96R28; 2 sites.
DR iPTMnet; Q96R28; -.
DR PhosphoSitePlus; Q96R28; -.
DR BioMuta; OR2M2; -.
DR DMDM; 85541044; -.
DR MassIVE; Q96R28; -.
DR PaxDb; Q96R28; -.
DR PRIDE; Q96R28; -.
DR Antibodypedia; 57431; 83 antibodies from 18 providers.
DR DNASU; 391194; -.
DR Ensembl; ENST00000641211.1; ENSP00000492974.1; ENSG00000198601.4.
DR Ensembl; ENST00000641836.1; ENSP00000493201.1; ENSG00000198601.4.
DR GeneID; 391194; -.
DR KEGG; hsa:391194; -.
DR MANE-Select; ENST00000641836.1; ENSP00000493201.1; NM_001004688.2; NP_001004688.1.
DR UCSC; uc010pzf.2; human.
DR CTD; 391194; -.
DR GeneCards; OR2M2; -.
DR HGNC; HGNC:8268; OR2M2.
DR HPA; ENSG00000198601; Not detected.
DR neXtProt; NX_Q96R28; -.
DR PharmGKB; PA32192; -.
DR VEuPathDB; HostDB:ENSG00000198601; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q96R28; -.
DR OMA; EKVIFIC; -.
DR OrthoDB; 1004475at2759; -.
DR PhylomeDB; Q96R28; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q96R28; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391194; 7 hits in 599 CRISPR screens.
DR GeneWiki; OR2M2; -.
DR GenomeRNAi; 391194; -.
DR Pharos; Q96R28; Tdark.
DR PRO; PR:Q96R28; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96R28; protein.
DR Bgee; ENSG00000198601; Expressed in anatomical system and 5 other tissues.
DR ExpressionAtlas; Q96R28; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..347
FT /note="Olfactory receptor 2M2"
FT /id="PRO_0000150491"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 87
FT /note="S -> C (in dbSNP:rs61156873)"
FT /id="VAR_062026"
FT VARIANT 220
FT /note="R -> G (in dbSNP:rs4244171)"
FT /id="VAR_059990"
FT VARIANT 235
FT /note="C -> R (in dbSNP:rs4916104)"
FT /id="VAR_059991"
FT VARIANT 237
FT /note="A -> T (in dbSNP:rs9435890)"
FT /id="VAR_034179"
FT CONFLICT 72
FT /note="M -> K (in Ref. 2; AAK95101)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 347 AA; 39177 MW; 3432AA0B3EC8F474 CRC64;
MAWENQTFNS DFILLGIFNH SPPHTFLFFL VLGIFLVAFM GNSVMVLLIY LDTQLHTPMY
FLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCVTQ IFFYISLSGS ECFLLAVMAY
DRYIAICHPL RYTNLMNPKI CGLMATFSWI LGSTDGIIDA VATFSFSFCG SREIAHFFCE
FPSLLILSCN DTSIFEEVIF ICCIVMLVFP VAIIIASYAR VILAVIHMGS GEGRCKAFTT
CSSHLMVVGM YYGAALFMYI RPTSDHSPTQ DKMVSVFYTI LTPMLNPLIY SLRNKEVTRA
FMKILGKGKS ESELPHKLYV LLFAKFFFLI SIFFYDVKIL ALIMYIA
