OR2M7_HUMAN
ID OR2M7_HUMAN Reviewed; 312 AA.
AC Q8NG81; B2RNL0; Q6IEX6;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 2M7;
DE AltName: Full=Olfactory receptor OR1-58;
GN Name=OR2M7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2M7";
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DR EMBL; AB065954; BAC06167.1; -; Genomic_DNA.
DR EMBL; AL450303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136944; AAI36945.1; -; mRNA.
DR EMBL; BC136946; AAI36947.1; -; mRNA.
DR EMBL; BK004486; DAA04884.1; -; Genomic_DNA.
DR CCDS; CCDS31111.1; -.
DR RefSeq; NP_001004691.1; NM_001004691.1.
DR AlphaFoldDB; Q8NG81; -.
DR SMR; Q8NG81; -.
DR BioGRID; 133853; 41.
DR STRING; 9606.ENSP00000324557; -.
DR GlyGen; Q8NG81; 1 site.
DR iPTMnet; Q8NG81; -.
DR PhosphoSitePlus; Q8NG81; -.
DR BioMuta; OR2M7; -.
DR DMDM; 38372497; -.
DR MassIVE; Q8NG81; -.
DR PaxDb; Q8NG81; -.
DR PRIDE; Q8NG81; -.
DR Antibodypedia; 57435; 88 antibodies from 20 providers.
DR DNASU; 391196; -.
DR Ensembl; ENST00000317965.3; ENSP00000324557.2; ENSG00000177186.3.
DR GeneID; 391196; -.
DR KEGG; hsa:391196; -.
DR MANE-Select; ENST00000317965.3; ENSP00000324557.2; NM_001004691.1; NP_001004691.1.
DR UCSC; uc010pzk.2; human.
DR CTD; 391196; -.
DR GeneCards; OR2M7; -.
DR HGNC; HGNC:19594; OR2M7.
DR HPA; ENSG00000177186; Not detected.
DR MIM; 618509; gene.
DR neXtProt; NX_Q8NG81; -.
DR OpenTargets; ENSG00000177186; -.
DR PharmGKB; PA134874354; -.
DR VEuPathDB; HostDB:ENSG00000177186; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NG81; -.
DR OMA; YIQPTSH; -.
DR OrthoDB; 1004475at2759; -.
DR PhylomeDB; Q8NG81; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NG81; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391196; 6 hits in 609 CRISPR screens.
DR GeneWiki; OR2M7; -.
DR GenomeRNAi; 391196; -.
DR Pharos; Q8NG81; Tdark.
DR PRO; PR:Q8NG81; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NG81; protein.
DR Bgee; ENSG00000177186; Expressed in primary visual cortex and 5 other tissues.
DR ExpressionAtlas; Q8NG81; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2M7"
FT /id="PRO_0000150494"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 35
FT /note="F -> L (in dbSNP:rs7555424)"
FT /id="VAR_059992"
FT VARIANT 78
FT /note="V -> A (in dbSNP:rs7555310)"
FT /id="VAR_053149"
FT VARIANT 178
FT /note="C -> F (in dbSNP:rs4916130)"
FT /id="VAR_053150"
FT VARIANT 191
FT /note="D -> N (in dbSNP:rs4916129)"
FT /id="VAR_059993"
SQ SEQUENCE 312 AA; 34902 MW; 42A9A1D7EB861E88 CRC64;
MAWENQTFNS DFLLLGIFNH SPTHTFLFFL VLAIFSVAFM GNSIMVLLIY LDTQLHTPMY
FLLSQLSLMD LMLICTTVPK MAFNYLSGSK SISMAGCATQ IFFYISLLGS ECFLLAVMSY
DRYTAICHPL RYTNLMRPKI CGLMTAFSWI LGSTDGIIDA VATFSFSYCG SREIAHFCCD
FPSLLILSCN DTSIFEEVIF ICCIVMLVFP VAIIITSYAR VILAVIHMGS GEGRRKAFTT
CSSHLMVVGM YYGAGLFMCI QPTSHHSPMQ DKMVSVFYTI VTPMLNPLIY SLRNKEVTRA
LMKILGKGKS GD
