OR2S1_HUMAN
ID OR2S1_HUMAN Reviewed; 319 AA.
AC Q9NQN1; Q2M3L0; Q6IF19; Q96R42;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Olfactory receptor 2S2;
DE AltName: Full=Olfactory receptor OR9-3;
GN Name=OR2S2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-290.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2S2";
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DR EMBL; AL135841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104869; AAI04870.1; -; mRNA.
DR EMBL; BC113651; AAI13652.1; -; mRNA.
DR EMBL; AF399601; AAK95086.1; -; Genomic_DNA.
DR EMBL; BK004443; DAA04841.1; -; Genomic_DNA.
DR CCDS; CCDS6596.2; -.
DR RefSeq; NP_063950.2; NM_019897.2.
DR AlphaFoldDB; Q9NQN1; -.
DR SMR; Q9NQN1; -.
DR BioGRID; 121169; 2.
DR IntAct; Q9NQN1; 1.
DR STRING; 9606.ENSP00000485066; -.
DR GlyGen; Q9NQN1; 1 site.
DR iPTMnet; Q9NQN1; -.
DR PhosphoSitePlus; Q9NQN1; -.
DR BioMuta; OR2S2; -.
DR DMDM; 14423818; -.
DR MassIVE; Q9NQN1; -.
DR PaxDb; Q9NQN1; -.
DR PeptideAtlas; Q9NQN1; -.
DR PRIDE; Q9NQN1; -.
DR Antibodypedia; 79068; 30 antibodies from 14 providers.
DR DNASU; 56656; -.
DR Ensembl; ENST00000341959.2; ENSP00000344040.2; ENSG00000278889.4.
DR GeneID; 56656; -.
DR KEGG; hsa:56656; -.
DR MANE-Select; ENST00000341959.2; ENSP00000344040.2; NM_019897.2; NP_063950.2.
DR UCSC; uc011lpi.2; human.
DR CTD; 56656; -.
DR GeneCards; OR2S2; -.
DR HGNC; HGNC:8276; OR2S2.
DR HPA; ENSG00000278889; Not detected.
DR neXtProt; NX_Q9NQN1; -.
DR PharmGKB; PA32200; -.
DR VEuPathDB; HostDB:ENSG00000278889; -.
DR eggNOG; ENOG502TDYB; Eukaryota.
DR GeneTree; ENSGT01040000240406; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q9NQN1; -.
DR OMA; PKSKDSM; -.
DR OrthoDB; 1029720at2759; -.
DR PhylomeDB; Q9NQN1; -.
DR TreeFam; TF352686; -.
DR PathwayCommons; Q9NQN1; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9NQN1; -.
DR BioGRID-ORCS; 56656; 12 hits in 666 CRISPR screens.
DR GeneWiki; OR2S2; -.
DR GenomeRNAi; 56656; -.
DR Pharos; Q9NQN1; Tdark.
DR PRO; PR:Q9NQN1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9NQN1; protein.
DR Bgee; ENSG00000278889; Expressed in colonic mucosa and 4 other tissues.
DR Genevisible; Q9NQN1; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 2S2"
FT /id="PRO_0000150495"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 17
FT /note="R -> G (in dbSNP:rs2233558)"
FT /id="VAR_059994"
FT VARIANT 30
FT /note="V -> M (in dbSNP:rs2233559)"
FT /id="VAR_059995"
FT VARIANT 89
FT /note="P -> S (in dbSNP:rs2233560)"
FT /id="VAR_059996"
FT VARIANT 123
FT /note="R -> H (in dbSNP:rs2233563)"
FT /id="VAR_059997"
FT VARIANT 143
FT /note="M -> V (in dbSNP:rs2233564)"
FT /id="VAR_059998"
FT VARIANT 161
FT /note="T -> A (in dbSNP:rs2233565)"
FT /id="VAR_059999"
FT VARIANT 287
FT /note="V -> A (in dbSNP:rs2233570)"
FT /id="VAR_060000"
SQ SEQUENCE 319 AA; 35172 MW; 602602FCA96A179F CRC64;
MEKANETSPV MGFVLLRLSA HPELEKTFFV LILLMYLVIL LGNGVLILVT ILDSRLHTPM
YFFLGNLSFL DICFTTSSVP LVLDSFLTPQ ETISFSACAV QMALSFAMAG TECLLLSMMA
FDRYVAICNP LRYSVIMSKA AYMPMAASSW AIGGAASVVH TSLAIQLPFC GDNVINHFTC
EILAVLKLAC ADISINVISM EVTNVIFLGV PVLFISFSYV FIITTILRIP SAEGRKKVFS
TCSAHLTVVI VFYGTLFFMY GKPKSKDSMG ADKEDLSDKL IPLFYGVVTP MLNPIIYSLR
NKDVKAAVRR LLRPKGFTQ
