OR2T1_HUMAN
ID OR2T1_HUMAN Reviewed; 369 AA.
AC O43869; Q6IEZ9;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Olfactory receptor 2T1;
DE AltName: Full=Olfactory receptor 1-25;
DE Short=OR1-25;
DE AltName: Full=Olfactory receptor OR1-61;
GN Name=OR2T1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-333.
RX PubMed=9500546; DOI=10.1038/ng0398-243;
RA Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA Demaille J.G., Giorgi D.;
RT "Distribution of olfactory receptor genes in the human genome.";
RL Nat. Genet. 18:243-250(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-333.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-52 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T1";
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DR EMBL; AC138089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U86215; AAC39611.1; -; Genomic_DNA.
DR EMBL; AF399613; AAK95098.1; -; Genomic_DNA.
DR EMBL; BK004463; DAA04861.1; -; Genomic_DNA.
DR RefSeq; NP_112166.1; NM_030904.1.
DR AlphaFoldDB; O43869; -.
DR SMR; O43869; -.
DR BioGRID; 117796; 4.
DR STRING; 9606.ENSP00000355430; -.
DR GlyGen; O43869; 1 site.
DR iPTMnet; O43869; -.
DR PhosphoSitePlus; O43869; -.
DR BioMuta; OR2T1; -.
DR MassIVE; O43869; -.
DR PaxDb; O43869; -.
DR PRIDE; O43869; -.
DR DNASU; 26696; -.
DR Ensembl; ENST00000611851.1; ENSP00000479603.1; ENSG00000273508.1.
DR Ensembl; ENST00000613540.1; ENSP00000482752.1; ENSG00000275244.1.
DR GeneID; 26696; -.
DR KEGG; hsa:26696; -.
DR UCSC; uc010pzm.2; human.
DR CTD; 26696; -.
DR GeneCards; OR2T1; -.
DR HGNC; HGNC:8277; OR2T1.
DR neXtProt; NX_O43869; -.
DR PharmGKB; PA32201; -.
DR eggNOG; ENOG502RTYZ; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; O43869; -.
DR OrthoDB; 1130077at2759; -.
DR PhylomeDB; O43869; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; O43869; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26696; 10 hits in 678 CRISPR screens.
DR GeneWiki; OR2T1; -.
DR GenomeRNAi; 26696; -.
DR Pharos; O43869; Tdark.
DR PRO; PR:O43869; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O43869; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..369
FT /note="Olfactory receptor 2T1"
FT /id="PRO_0000150496"
FT TOPO_DOM 1..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..107
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..148
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..247
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..321
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..342
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 147..239
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 25
FT /note="H -> R (in dbSNP:rs28599722)"
FT /id="VAR_057541"
SQ SEQUENCE 369 AA; 41996 MW; 9D8E52A0312BEC3B CRC64;
MWQEYYFLNV FFPLLKVCCL TINSHVVILL PWECYHLIWK ILPYIGTTVG SMEEYNTSST
DFTFMGLFNR KETSGLIFAI ISIIFFTALM ANGVMIFLIQ TDLRLHTPMY FLLSHLSLID
MMYISTIVPK MLVNYLLDQR TISFVGCTAQ HFLYLTLVGA EFFLLGLMAY DRYVAICNPL
RYPVLMSRRV CWMIIAGSWF GGSLDGFLLT PITMSFPFCN SREINHFFCE APAVLKLACA
DTALYETVMY VCCVLMLLIP FSVVLASYAR ILTTVQCMSS VEGRKKAFAT CSSHMTVVSL
FYGAAMYTYM LPHSYHKPAQ DKVLSVFYTI LTPMLNPLIY SLRNKDVTGA LKRALGRFKG
PQRVSGGVF
