OR2T2_HUMAN
ID OR2T2_HUMAN Reviewed; 324 AA.
AC Q6IF00; B2RNM1; B9EH01;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Olfactory receptor 2T2;
DE AltName: Full=Olfactory receptor OR1-43;
GN Name=OR2T2; Synonyms=OR2T2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T2";
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DR EMBL; AC138089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136961; AAI36962.1; -; mRNA.
DR EMBL; BC136962; AAI36963.1; -; mRNA.
DR EMBL; BK004462; DAA04860.1; -; Genomic_DNA.
DR CCDS; CCDS31116.1; -.
DR RefSeq; NP_001004136.1; NM_001004136.1.
DR AlphaFoldDB; Q6IF00; -.
DR SMR; Q6IF00; -.
DR BioGRID; 135300; 3.
DR STRING; 9606.ENSP00000343062; -.
DR GlyGen; Q6IF00; 1 site.
DR iPTMnet; Q6IF00; -.
DR PhosphoSitePlus; Q6IF00; -.
DR BioMuta; OR2T2; -.
DR DMDM; 74762309; -.
DR MassIVE; Q6IF00; -.
DR PaxDb; Q6IF00; -.
DR PeptideAtlas; Q6IF00; -.
DR PRIDE; Q6IF00; -.
DR Antibodypedia; 57440; 42 antibodies from 13 providers.
DR DNASU; 401992; -.
DR Ensembl; ENST00000610282.1; ENSP00000482837.1; ENSG00000276821.1.
DR Ensembl; ENST00000616594.2; ENSP00000481002.1; ENSG00000275754.2.
DR Ensembl; ENST00000641925.2; ENSP00000492947.1; ENSG00000196240.6.
DR Ensembl; ENST00000642130.1; ENSP00000493326.1; ENSG00000196240.6.
DR GeneID; 401992; -.
DR KEGG; hsa:401992; -.
DR MANE-Select; ENST00000641925.2; ENSP00000492947.1; NM_001004136.2; NP_001004136.1.
DR UCSC; uc001iek.1; human.
DR CTD; 401992; -.
DR GeneCards; OR2T2; -.
DR HGNC; HGNC:14725; OR2T2.
DR HPA; ENSG00000196240; Not detected.
DR neXtProt; NX_Q6IF00; -.
DR PharmGKB; PA32202; -.
DR VEuPathDB; HostDB:ENSG00000196240; -.
DR eggNOG; ENOG502T9MD; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q6IF00; -.
DR OMA; TVHRMTS; -.
DR OrthoDB; 914755at2759; -.
DR PhylomeDB; Q6IF00; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q6IF00; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 401992; 18 hits in 575 CRISPR screens.
DR GeneWiki; OR2T2; -.
DR GenomeRNAi; 401992; -.
DR Pharos; Q6IF00; Tdark.
DR PRO; PR:Q6IF00; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6IF00; protein.
DR Bgee; ENSG00000196240; Expressed in adult mammalian kidney and 5 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 2T2"
FT /id="PRO_0000150497"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 9
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 324 AA; 36228 MW; AF11D073719A994A CRC64;
MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA IVFSIFVVAI TANLVMILLI HMDSRLHTPM
YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV QIFLYLTLIG GEFFLLGLMA
YDRYVAVCNP LRYPLLMNRR VCLFMVVGSW VGGSLDGFML TPVTMSFPFC RSREINHFFC
EIPAVLKLSC TDTSLYETLM YACCVLMLLI PLSVISVSYT HILLTVHRMN SAEGRRKAFA
TCSSHIMVVS VFYGAAFYTN VLPHSYHTPE KDKVVSAFYT ILTPMLNPLI YSLRNKDVAA
ALRKVLGRCG SSQSIRVATV IRKG
