OR2T3_HUMAN
ID OR2T3_HUMAN Reviewed; 318 AA.
AC Q8NH03; B2RNJ1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 2T3;
GN Name=OR2T3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-313.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T3";
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DR EMBL; AC138089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136915; AAI36916.1; -; mRNA.
DR EMBL; BC136916; AAI36917.1; -; mRNA.
DR EMBL; AB065612; BAC05839.1; -; Genomic_DNA.
DR CCDS; CCDS31117.1; -.
DR RefSeq; NP_001005495.1; NM_001005495.1.
DR AlphaFoldDB; Q8NH03; -.
DR SMR; Q8NH03; -.
DR STRING; 9606.ENSP00000352604; -.
DR GlyGen; Q8NH03; 2 sites.
DR BioMuta; OR2T3; -.
DR DMDM; 85541045; -.
DR MassIVE; Q8NH03; -.
DR PaxDb; Q8NH03; -.
DR PeptideAtlas; Q8NH03; -.
DR PRIDE; Q8NH03; -.
DR Antibodypedia; 57441; 73 antibodies from 18 providers.
DR DNASU; 343173; -.
DR Ensembl; ENST00000359594.3; ENSP00000352604.2; ENSG00000196539.3.
DR Ensembl; ENST00000610467.2; ENSP00000478611.1; ENSG00000277113.2.
DR Ensembl; ENST00000614898.1; ENSP00000480124.1; ENSG00000278377.1.
DR GeneID; 343173; -.
DR KEGG; hsa:343173; -.
DR MANE-Select; ENST00000359594.3; ENSP00000352604.2; NM_001005495.1; NP_001005495.1.
DR UCSC; uc001iel.1; human.
DR CTD; 343173; -.
DR GeneCards; OR2T3; -.
DR HGNC; HGNC:14727; OR2T3.
DR HPA; ENSG00000196539; Not detected.
DR neXtProt; NX_Q8NH03; -.
DR OpenTargets; ENSG00000196539; -.
DR PharmGKB; PA32203; -.
DR VEuPathDB; HostDB:ENSG00000196539; -.
DR eggNOG; ENOG502T92R; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NH03; -.
DR OMA; ISPLGCE; -.
DR OrthoDB; 963616at2759; -.
DR PhylomeDB; Q8NH03; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NH03; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 343173; 238 hits in 583 CRISPR screens.
DR GenomeRNAi; 343173; -.
DR Pharos; Q8NH03; Tdark.
DR PRO; PR:Q8NH03; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NH03; protein.
DR Bgee; ENSG00000196539; Expressed in vermiform appendix and 4 other tissues.
DR ExpressionAtlas; Q8NH03; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 2T3"
FT /id="PRO_0000150498"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 204
FT /note="M -> T (in dbSNP:rs1770110)"
FT /id="VAR_053151"
FT CONFLICT 306
FT /note="L -> M (in Ref. 3; BAC05839)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35598 MW; 9BB2D6495FACB849 CRC64;
MCSGNQTSQN QTASTDFTLT GLFAESKHAA LLYTVTFLLF LMALTGNALL ILLIHSEPRL
HTPMYFFISQ LALMDLMYLC VTVPKMLVGQ VTGDDTISPS GCGIQMFFYL TLAGAEVFLL
AAMAYDRYAA VCRPLHYPLL MNQRVCQLLV SACWVLGMVD GLLLTPITMS FPFCQSRKIL
SFFCETPALL KLSCSDVSLY KTLMYLCCIL MLLAPIMVIS SSYTLILHLI HRMNSAAGHR
KALATCSSHM IIVLLLFGAS FYTYMLPSSY HTAEQDMMVS AFYTIFTPVL NPLIYSLRNK
DVTRALRSMM QSRMNQEK
