OR2T4_HUMAN
ID OR2T4_HUMAN Reviewed; 348 AA.
AC Q8NH00; Q6IEZ8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 2T4;
DE AltName: Full=Olfactory receptor OR1-60;
GN Name=OR2T4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-29 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05842.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T4";
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DR EMBL; AB065615; BAC05842.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC138089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004464; DAA04862.1; -; Genomic_DNA.
DR RefSeq; NP_001004696.1; NM_001004696.1.
DR AlphaFoldDB; Q8NH00; -.
DR SMR; Q8NH00; -.
DR STRING; 9606.ENSP00000355431; -.
DR GlyGen; Q8NH00; 3 sites.
DR iPTMnet; Q8NH00; -.
DR PhosphoSitePlus; Q8NH00; -.
DR BioMuta; OR2T4; -.
DR DMDM; 229462930; -.
DR MassIVE; Q8NH00; -.
DR PaxDb; Q8NH00; -.
DR PeptideAtlas; Q8NH00; -.
DR PRIDE; Q8NH00; -.
DR Antibodypedia; 64191; 14 antibodies from 11 providers.
DR DNASU; 127074; -.
DR Ensembl; ENST00000621754.1; ENSP00000478105.1; ENSG00000274870.1.
DR Ensembl; ENST00000622637.1; ENSP00000484014.1; ENSG00000275617.1.
DR GeneID; 127074; -.
DR KEGG; hsa:127074; -.
DR UCSC; uc001ieh.1; human.
DR CTD; 127074; -.
DR GeneCards; OR2T4; -.
DR HGNC; HGNC:15016; OR2T4.
DR HPA; ENSG00000196944; Not detected.
DR neXtProt; NX_Q8NH00; -.
DR PharmGKB; PA134876557; -.
DR VEuPathDB; HostDB:ENSG00000196944; -.
DR eggNOG; ENOG502T92P; Eukaryota.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NH00; -.
DR OrthoDB; 1039038at2759; -.
DR PhylomeDB; Q8NH00; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NH00; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 127074; 74 hits in 677 CRISPR screens.
DR GeneWiki; OR2T4; -.
DR GenomeRNAi; 127074; -.
DR Pharos; Q8NH00; Tdark.
DR PRO; PR:Q8NH00; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NH00; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..348
FT /note="Olfactory receptor 2T4"
FT /id="PRO_0000150499"
FT TOPO_DOM 1..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..81
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..89
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..111
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..152
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..251
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..291
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..304
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..324
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 129..221
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 31
FT /note="N -> S (in dbSNP:rs57795102)"
FT /id="VAR_062027"
SQ SEQUENCE 348 AA; 39414 MW; 93469A947E1E0618 CRC64;
MDNITWMASH TGWSDFILMG LFRQSKHPMA NITWMANHTG WSDFILLGLF RQSKHPALLC
VVIFVVFLMA LSGNAVLILL IHCDAHLHTP MYFFISQLSL MDMAYISVTV PKMLLDQVMG
VNKISAPECG MQMFFYVTLA GSEFFLLATM AYDRYVAICH PLRYPVLMNH RVCLFLSSGC
WFLGSVDGFT FTPITMTFPF RGSREIHHFF CEVPAVLNLS CSDTSLYEIF MYLCCVLMLL
IPVVIISSSY LLILLTIHGM NSAEGRKKAF ATCSSHLTVV ILFYGAAIYT YMLPSSYHTP
EKDMMVSVFY TILTPVVNPL IYSLRNKDVM GALKKMLTVE PAFQKAME
