OR2T6_HUMAN
ID OR2T6_HUMAN Reviewed; 308 AA.
AC Q8NHC8; A6NE36;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Olfactory receptor 2T6;
DE AltName: Full=OST703;
DE AltName: Full=Olfactory receptor 2T9;
GN Name=OR2T6; Synonyms=OR2T6P, OR2T9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05705.1; Type=Miscellaneous discrepancy; Note=Hybrid of two separate genomic loci.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T6";
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DR EMBL; AB065438; BAC05705.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC138089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31114.1; -.
DR RefSeq; NP_001005471.1; NM_001005471.1.
DR AlphaFoldDB; Q8NHC8; -.
DR SMR; Q8NHC8; -.
DR BioGRID; 129055; 1.
DR IntAct; Q8NHC8; 1.
DR STRING; 9606.ENSP00000347965; -.
DR GlyGen; Q8NHC8; 1 site.
DR iPTMnet; Q8NHC8; -.
DR PhosphoSitePlus; Q8NHC8; -.
DR BioMuta; OR2T6; -.
DR DMDM; 166214964; -.
DR MassIVE; Q8NHC8; -.
DR PaxDb; Q8NHC8; -.
DR PeptideAtlas; Q8NHC8; -.
DR PRIDE; Q8NHC8; -.
DR Antibodypedia; 68598; 66 antibodies from 18 providers.
DR DNASU; 254879; -.
DR Ensembl; ENST00000612137.1; ENSP00000478358.1; ENSG00000278659.1.
DR Ensembl; ENST00000621336.1; ENSP00000481800.1; ENSG00000278689.1.
DR Ensembl; ENST00000641644.1; ENSP00000493366.1; ENSG00000198104.4.
DR GeneID; 254879; -.
DR KEGG; hsa:254879; -.
DR MANE-Select; ENST00000641644.1; ENSP00000493366.1; NM_001005471.2; NP_001005471.1.
DR UCSC; uc001iei.1; human.
DR CTD; 254879; -.
DR DisGeNET; 254879; -.
DR GeneCards; OR2T6; -.
DR HGNC; HGNC:15018; OR2T6.
DR HPA; ENSG00000198104; Not detected.
DR neXtProt; NX_Q8NHC8; -.
DR PharmGKB; PA32206; -.
DR VEuPathDB; HostDB:ENSG00000198104; -.
DR eggNOG; ENOG502RTYZ; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NHC8; -.
DR OMA; MSLPFCS; -.
DR OrthoDB; 1130077at2759; -.
DR PhylomeDB; Q8NHC8; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NHC8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NHC8; -.
DR BioGRID-ORCS; 254879; 6 hits in 670 CRISPR screens.
DR ChiTaRS; OR2T6; human.
DR GeneWiki; OR2T6; -.
DR GenomeRNAi; 254879; -.
DR Pharos; Q8NHC8; Tdark.
DR PRO; PR:Q8NHC8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NHC8; protein.
DR Bgee; ENSG00000198104; Expressed in anterior cingulate cortex and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 2T6"
FT /id="PRO_0000150501"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 21
FT /note="N -> D (in dbSNP:rs7417616)"
FT /id="VAR_060001"
FT VARIANT 23
FT /note="C -> G (in dbSNP:rs6587467)"
FT /id="VAR_060002"
FT VARIANT 57
FT /note="T -> N (in dbSNP:rs6693032)"
FT /id="VAR_053152"
FT VARIANT 159
FT /note="L -> P (in dbSNP:rs6701129)"
FT /id="VAR_053153"
FT VARIANT 243
FT /note="S -> A (in dbSNP:rs954475)"
FT /id="VAR_053154"
SQ SEQUENCE 308 AA; 34765 MW; 687529A6037E88B5 CRC64;
MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN IDPHLHTPMY
FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ CFLYMGFMGA EFFLLGLMAY
DRYVAICNPL RYPVLISWRV CWMILASSWF GGALDSFLLT PITMSLPFCA SHQINHFFCE
APTMLRLACG DKTTYETVMY VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT
CSSHMMVVTL FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA
LKRVVARC
