OR2T8_HUMAN
ID OR2T8_HUMAN Reviewed; 312 AA.
AC A6NH00;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Olfactory receptor 2T8;
GN Name=OR2T8; Synonyms=OR2T8P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T8";
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DR EMBL; AC099571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31100.1; -.
DR RefSeq; NP_001005522.1; NM_001005522.1.
DR RefSeq; XP_011542480.1; XM_011544178.2.
DR RefSeq; XP_016856661.1; XM_017001172.1.
DR AlphaFoldDB; A6NH00; -.
DR SMR; A6NH00; -.
DR STRING; 9606.ENSP00000326225; -.
DR GlyGen; A6NH00; 2 sites.
DR iPTMnet; A6NH00; -.
DR PhosphoSitePlus; A6NH00; -.
DR BioMuta; OR2T8; -.
DR PaxDb; A6NH00; -.
DR PRIDE; A6NH00; -.
DR Antibodypedia; 57425; 63 antibodies from 17 providers.
DR DNASU; 343172; -.
DR Ensembl; ENST00000641945.2; ENSP00000493286.1; ENSG00000177462.9.
DR GeneID; 343172; -.
DR KEGG; hsa:343172; -.
DR MANE-Select; ENST00000641945.2; ENSP00000493286.1; NM_001005522.2; NP_001005522.1.
DR UCSC; uc010pzc.2; human.
DR CTD; 343172; -.
DR GeneCards; OR2T8; -.
DR HGNC; HGNC:15020; OR2T8.
DR HPA; ENSG00000177462; Not detected.
DR neXtProt; NX_A6NH00; -.
DR PharmGKB; PA32208; -.
DR VEuPathDB; HostDB:ENSG00000177462; -.
DR eggNOG; ENOG502RU0Z; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; A6NH00; -.
DR OMA; WKLCLSM; -.
DR OrthoDB; 1004458at2759; -.
DR PhylomeDB; A6NH00; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; A6NH00; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; A6NH00; -.
DR BioGRID-ORCS; 343172; 9 hits in 598 CRISPR screens.
DR GenomeRNAi; 343172; -.
DR Pharos; A6NH00; Tdark.
DR PRO; PR:A6NH00; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A6NH00; protein.
DR Bgee; ENSG00000177462; Expressed in right lobe of thyroid gland and 35 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 2T8"
FT /id="PRO_0000311914"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..177
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 39
FT /note="G -> S (in dbSNP:rs11204563)"
FT /id="VAR_037342"
FT VARIANT 49
FT /note="W -> R (in dbSNP:rs11204564)"
FT /id="VAR_037343"
FT VARIANT 69
FT /note="V -> M (in dbSNP:rs28575687)"
FT /id="VAR_062028"
FT VARIANT 179
FT /note="T -> A (in dbSNP:rs4584426)"
FT /id="VAR_037344"
FT VARIANT 197
FT /note="M -> R (in dbSNP:rs4474294)"
FT /id="VAR_037345"
FT VARIANT 221
FT /note="A -> S (in dbSNP:rs4362017)"
FT /id="VAR_037346"
FT VARIANT 305
FT /note="R -> W (in dbSNP:rs6695357)"
FT /id="VAR_037347"
FT VARIANT 311
FT /note="R -> H (in dbSNP:rs58882030)"
FT /id="VAR_062029"
SQ SEQUENCE 312 AA; 34659 MW; 9708C7ABB1216EFD CRC64;
MENGSYTSYF ILLGLFNHTR AHQVLFMMVL SIVLTSLFGN SLMILLIHWD HRLHTPMYFL
LSQLSLMDVM LVSTTVPKMA ADYLTGSKAI SRAGCGAQIF FLPTLGGGEC FLLAAMAYDR
YAAVCHPLRY PTLMSWQLCL RMNLSCWLLG AADGLLQAVA TLSFPYCGAH EIDHFFCETP
VLVRLACADT SVFENAMYIC CVLMLLVPFS LILSSYGLIL AAVLHMRSTE ARKKAFATCS
SHVAVVGLFY GAAIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV KNSEVKGALT
RCMGRCVALS RE
