OR2V1_HUMAN
ID OR2V1_HUMAN Reviewed; 315 AA.
AC Q8NHB1;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Olfactory receptor 2V1;
GN Name=OR2V1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05724.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2V1";
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DR EMBL; AB065465; BAC05724.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AC008620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS58992.1; -.
DR RefSeq; NP_001245212.1; NM_001258283.1.
DR AlphaFoldDB; Q8NHB1; -.
DR SMR; Q8NHB1; -.
DR STRING; 9606.ENSP00000404102; -.
DR GlyGen; Q8NHB1; 1 site.
DR iPTMnet; Q8NHB1; -.
DR PhosphoSitePlus; Q8NHB1; -.
DR BioMuta; OR2V1; -.
DR DMDM; 162416234; -.
DR MassIVE; Q8NHB1; -.
DR PaxDb; Q8NHB1; -.
DR PeptideAtlas; Q8NHB1; -.
DR PRIDE; Q8NHB1; -.
DR Antibodypedia; 62267; 16 antibodies from 9 providers.
DR DNASU; 26693; -.
DR Ensembl; ENST00000641318.1; ENSP00000492958.1; ENSG00000185372.4.
DR Ensembl; ENST00000641551.1; ENSP00000492946.1; ENSG00000185372.4.
DR Ensembl; ENST00000642036.1; ENSP00000492982.1; ENSG00000185372.4.
DR GeneID; 26693; -.
DR KEGG; hsa:26693; -.
DR MANE-Select; ENST00000641551.1; ENSP00000492946.1; NM_001258283.2; NP_001245212.1.
DR UCSC; uc031smg.1; human.
DR CTD; 26693; -.
DR GeneCards; OR2V1; -.
DR HGNC; HGNC:8280; OR2V1.
DR HPA; ENSG00000185372; Tissue enhanced (liver, retina).
DR neXtProt; NX_Q8NHB1; -.
DR VEuPathDB; HostDB:ENSG00000185372; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NHB1; -.
DR OMA; MGIWLNQ; -.
DR OrthoDB; 905402at2759; -.
DR PhylomeDB; Q8NHB1; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NHB1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NHB1; -.
DR BioGRID-ORCS; 26693; 10 hits in 671 CRISPR screens.
DR GenomeRNAi; 26693; -.
DR Pharos; Q8NHB1; Tdark.
DR PRO; PR:Q8NHB1; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8NHB1; protein.
DR Bgee; ENSG00000185372; Expressed in right uterine tube and 4 other tissues.
DR ExpressionAtlas; Q8NHB1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 2V1"
FT /id="PRO_0000312488"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 315 AA; 34857 MW; DA8CDA246020E9E1 CRC64;
MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI YLDAGLHTPM
YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI QIGFFVSLVG SEGLLLGLMA
YDRYVAVSHP LHYPILMNQR VCLQITGSSW AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC
EVQALLKLAC ADTSLFDTLL FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA
TCSSHLTAVT LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG
ALRKGLDRCR IGSQH
