OR2V2_HUMAN
ID OR2V2_HUMAN Reviewed; 315 AA.
AC Q96R30; Q6IFL6; Q8NGV1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 2V2;
DE AltName: Full=Olfactory receptor 2V3;
DE AltName: Full=Olfactory receptor OR5-3;
GN Name=OR2V2; Synonyms=OR2V3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-221.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2V2";
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DR EMBL; AB065675; BAC05900.1; -; Genomic_DNA.
DR EMBL; AF399614; AAK95099.1; -; Genomic_DNA.
DR EMBL; BK004246; DAA04644.1; -; Genomic_DNA.
DR CCDS; CCDS4461.1; -.
DR RefSeq; NP_996763.1; NM_206880.1.
DR AlphaFoldDB; Q96R30; -.
DR SMR; Q96R30; -.
DR STRING; 9606.ENSP00000332185; -.
DR GlyGen; Q96R30; 1 site.
DR iPTMnet; Q96R30; -.
DR PhosphoSitePlus; Q96R30; -.
DR BioMuta; OR2V2; -.
DR DMDM; 55977873; -.
DR MassIVE; Q96R30; -.
DR PaxDb; Q96R30; -.
DR PeptideAtlas; Q96R30; -.
DR PRIDE; Q96R30; -.
DR Antibodypedia; 62268; 70 antibodies from 19 providers.
DR DNASU; 285659; -.
DR Ensembl; ENST00000641492.1; ENSP00000493207.1; ENSG00000182613.3.
DR Ensembl; ENST00000641791.1; ENSP00000493017.1; ENSG00000182613.3.
DR GeneID; 285659; -.
DR KEGG; hsa:285659; -.
DR MANE-Select; ENST00000641492.1; ENSP00000493207.1; NM_206880.2; NP_996763.1.
DR UCSC; uc011dhj.2; human.
DR CTD; 285659; -.
DR DisGeNET; 285659; -.
DR GeneCards; OR2V2; -.
DR HGNC; HGNC:15341; OR2V2.
DR HPA; ENSG00000182613; Not detected.
DR neXtProt; NX_Q96R30; -.
DR OpenTargets; ENSG00000182613; -.
DR PharmGKB; PA32212; -.
DR VEuPathDB; HostDB:ENSG00000182613; -.
DR eggNOG; ENOG502SHXQ; Eukaryota.
DR GeneTree; ENSGT01050000244844; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q96R30; -.
DR OMA; METWANQ; -.
DR OrthoDB; 905402at2759; -.
DR PhylomeDB; Q96R30; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q96R30; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 285659; 9 hits in 669 CRISPR screens.
DR GeneWiki; OR2V2; -.
DR GenomeRNAi; 285659; -.
DR Pharos; Q96R30; Tdark.
DR PRO; PR:Q96R30; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96R30; protein.
DR Bgee; ENSG00000182613; Expressed in right uterine tube.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 2V2"
FT /id="PRO_0000150510"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 34
FT /note="A -> V (in dbSNP:rs17617270)"
FT /id="VAR_053160"
FT VARIANT 221
FT /note="H -> R (in dbSNP:rs2546423)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_053161"
SQ SEQUENCE 315 AA; 35339 MW; 8D84C611F9D48B74 CRC64;
METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI YMDPHLHTPM
YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI QIGLFVCLVG SEGLLLGLMA
YDRYVAISHP LHYPILMNQR VCLQITGSSW AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC
EMLSLLKLAC VDTSLFEKVI FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA
TCSSHLTAVT LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG
ALRKGLDRCR IGSQH
