OR2W1_HUMAN
ID OR2W1_HUMAN Reviewed; 320 AA.
AC Q9Y3N9; B0S7Y5; Q5JNZ1; Q6IEU0; Q96R17; Q9GZL0; Q9GZL1;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Olfactory receptor 2W1;
DE AltName: Full=Hs6M1-15;
DE AltName: Full=Olfactory receptor OR6-13;
GN Name=OR2W1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-81 AND ASN-296.
RA Ziegler A., Ehlers A., Forbes S.A., Trowsdale J., Uchanska-Ziegler B.,
RA Volz A., Younger R., Beck S.;
RT "Polymorphic olfactory receptor genes and HLA loci constitute extended
RT haplotypes.";
RL (In) Kasahara M. (eds.);
RL Major histocompatibility complex-evolution, structure, and function,
RL pp.110-130, Springer-Verlag, Tokyo (2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2W1";
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DR EMBL; AJ302594; CAC20514.1; -; Genomic_DNA.
DR EMBL; AJ302595; CAC20515.1; -; Genomic_DNA.
DR EMBL; AJ302596; CAC20516.1; -; Genomic_DNA.
DR EMBL; AJ302597; CAC20517.1; -; Genomic_DNA.
DR EMBL; AJ302598; CAC20518.1; -; Genomic_DNA.
DR EMBL; AJ302599; CAC20519.1; -; Genomic_DNA.
DR EMBL; AJ302600; CAC20520.1; -; Genomic_DNA.
DR EMBL; AJ302601; CAC20521.1; -; Genomic_DNA.
DR EMBL; AJ302602; CAC20522.1; -; Genomic_DNA.
DR EMBL; AJ302603; CAC20523.1; -; Genomic_DNA.
DR EMBL; AL035402; CAB42853.1; -; Genomic_DNA.
DR EMBL; AL662791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929561; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03181.1; -; Genomic_DNA.
DR EMBL; BC103870; AAI03871.1; -; mRNA.
DR EMBL; BC103871; AAI03872.1; -; mRNA.
DR EMBL; BC103872; AAI03873.1; -; mRNA.
DR EMBL; AF399628; AAK95113.1; -; Genomic_DNA.
DR EMBL; BK004522; DAA04920.1; -; Genomic_DNA.
DR CCDS; CCDS4656.1; -.
DR RefSeq; NP_112165.1; NM_030903.3.
DR AlphaFoldDB; Q9Y3N9; -.
DR SMR; Q9Y3N9; -.
DR BioGRID; 117792; 1.
DR STRING; 9606.ENSP00000366380; -.
DR GlyGen; Q9Y3N9; 3 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9Y3N9; -.
DR PhosphoSitePlus; Q9Y3N9; -.
DR BioMuta; OR2W1; -.
DR DMDM; 14423828; -.
DR MassIVE; Q9Y3N9; -.
DR PaxDb; Q9Y3N9; -.
DR PeptideAtlas; Q9Y3N9; -.
DR PRIDE; Q9Y3N9; -.
DR Antibodypedia; 25938; 91 antibodies from 20 providers.
DR DNASU; 26692; -.
DR Ensembl; ENST00000377175.2; ENSP00000366380.1; ENSG00000204704.3.
DR Ensembl; ENST00000383654.2; ENSP00000373150.2; ENSG00000206525.2.
DR Ensembl; ENST00000411447.1; ENSP00000388144.1; ENSG00000227639.1.
DR Ensembl; ENST00000420540.1; ENSP00000392635.1; ENSG00000228977.1.
DR Ensembl; ENST00000421027.1; ENSP00000412537.1; ENSG00000226463.1.
DR Ensembl; ENST00000421766.1; ENSP00000389825.1; ENSG00000234101.1.
DR Ensembl; ENST00000439723.1; ENSP00000401866.1; ENSG00000228652.1.
DR Ensembl; ENST00000446776.1; ENSP00000405025.1; ENSG00000229328.1.
DR GeneID; 26692; -.
DR KEGG; hsa:26692; -.
DR MANE-Select; ENST00000377175.2; ENSP00000366380.1; NM_030903.3; NP_112165.1.
DR UCSC; uc003nlw.3; human.
DR CTD; 26692; -.
DR GeneCards; OR2W1; -.
DR HGNC; HGNC:8281; OR2W1.
DR HPA; ENSG00000204704; Not detected.
DR neXtProt; NX_Q9Y3N9; -.
DR PharmGKB; PA32214; -.
DR VEuPathDB; HostDB:ENSG00000204704; -.
DR eggNOG; ENOG502T8AH; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9Y3N9; -.
DR OMA; WLGSVEC; -.
DR OrthoDB; 897235at2759; -.
DR PhylomeDB; Q9Y3N9; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q9Y3N9; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9Y3N9; -.
DR BioGRID-ORCS; 26692; 8 hits in 651 CRISPR screens.
DR GeneWiki; OR2W1; -.
DR GenomeRNAi; 26692; -.
DR Pharos; Q9Y3N9; Tdark.
DR PRO; PR:Q9Y3N9; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9Y3N9; protein.
DR Bgee; ENSG00000204704; Expressed in sural nerve.
DR ExpressionAtlas; Q9Y3N9; baseline and differential.
DR Genevisible; Q9Y3N9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 2W1"
FT /id="PRO_0000150511"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 81
FT /note="M -> V (in allele 6M1-15*03; dbSNP:rs34892006)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_010953"
FT VARIANT 296
FT /note="D -> N (in allele 6M1-15*02; dbSNP:rs35771565)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_010954"
SQ SEQUENCE 320 AA; 36101 MW; 7A8ECD33F443E1D0 CRC64;
MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL LDSQLHTPMY
FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ LYVYMWLGSV ECLLLAVMSY
DRFTAICKPL HYFVVMNPHL CLKMIIMIWS ISLANSVVLC TLTLNLPTCG NNILDHFLCE
LPALVKIACV DTTTVEMSVF ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT
CGSHLTVVSM FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA
LKKLMRFHHK STKIKRNCKS
