OR2W3_HUMAN
ID OR2W3_HUMAN Reviewed; 314 AA.
AC Q7Z3T1; Q6IF06; Q8NG86;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Olfactory receptor 2W3;
DE AltName: Full=Olfactory receptor 2W8;
DE AltName: Full=Olfactory receptor OR1-49;
GN Name=OR2W3; Synonyms=OR2W3P, OR2W8P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-196; LYS-272 AND
RP THR-275.
RC TISSUE=Fetal brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [5]
RP VARIANT TRP-142.
RX PubMed=25825126; DOI=10.1007/s00415-015-7718-3;
RA Nibbeling E., Schaake S., Tijssen M.A., Weissbach A., Groen J.L.,
RA Altenmueller E., Verbeek D.S., Lohmann K.;
RT "Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-
RT specific dystonia.";
RL J. Neurol. 262:1340-1343(2015).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2W3";
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DR EMBL; AB065949; BAC06162.1; -; Genomic_DNA.
DR EMBL; BX537432; CAD97674.1; -; mRNA.
DR EMBL; BK004456; DAA04854.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS31099.1; -.
DR RefSeq; NP_001001957.2; NM_001001957.2.
DR AlphaFoldDB; Q7Z3T1; -.
DR SMR; Q7Z3T1; -.
DR BioGRID; 131235; 4.
DR STRING; 9606.ENSP00000353516; -.
DR GlyGen; Q7Z3T1; 1 site.
DR BioMuta; OR2W3; -.
DR DMDM; 83305196; -.
DR PaxDb; Q7Z3T1; -.
DR PRIDE; Q7Z3T1; -.
DR Antibodypedia; 52554; 108 antibodies from 24 providers.
DR DNASU; 343171; -.
DR Ensembl; ENST00000360358.3; ENSP00000353516.3; ENSG00000238243.3.
DR GeneID; 343171; -.
DR KEGG; hsa:343171; -.
DR MANE-Select; ENST00000360358.3; ENSP00000353516.3; NM_001001957.2; NP_001001957.2.
DR UCSC; uc010pzb.2; human.
DR CTD; 343171; -.
DR DisGeNET; 343171; -.
DR GeneCards; OR2W3; -.
DR HGNC; HGNC:15021; OR2W3.
DR HPA; ENSG00000238243; Group enriched (bone marrow, brain, thyroid gland).
DR neXtProt; NX_Q7Z3T1; -.
DR OpenTargets; ENSG00000238243; -.
DR PharmGKB; PA32216; -.
DR VEuPathDB; HostDB:ENSG00000238243; -.
DR eggNOG; ENOG502TD9W; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q7Z3T1; -.
DR OMA; CGHRSVD; -.
DR OrthoDB; 1004661at2759; -.
DR PhylomeDB; Q7Z3T1; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q7Z3T1; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 343171; 8 hits in 673 CRISPR screens.
DR GeneWiki; OR2W3; -.
DR GenomeRNAi; 343171; -.
DR Pharos; Q7Z3T1; Tbio.
DR PRO; PR:Q7Z3T1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z3T1; protein.
DR Bgee; ENSG00000238243; Expressed in blood and 105 other tissues.
DR Genevisible; Q7Z3T1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 2W3"
FT /id="PRO_0000150512"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 142
FT /note="R -> W (found in a family with retinitis pigmentosa;
FT dbSNP:rs189993261)"
FT /evidence="ECO:0000269|PubMed:25825126"
FT /id="VAR_074043"
FT VARIANT 169
FT /note="C -> S (in dbSNP:rs12083024)"
FT /id="VAR_034180"
FT VARIANT 179
FT /note="R -> C (in dbSNP:rs10888267)"
FT /id="VAR_034181"
FT VARIANT 190
FT /note="V -> I (in dbSNP:rs12135078)"
FT /id="VAR_034182"
FT VARIANT 196
FT /note="E -> D (in dbSNP:rs12139390)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_034183"
FT VARIANT 272
FT /note="M -> K (in dbSNP:rs11204545)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_034184"
FT VARIANT 275
FT /note="M -> T (in dbSNP:rs11204546)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_034185"
SQ SEQUENCE 314 AA; 34789 MW; 3F53BC5912B7D6BC CRC64;
MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR LDPHLHTPMY
FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ LFLFLGLGGV ECLLLAVMAY
DRCVAICKPL HYMVIMNPRL CRGLVSVTWG CGVANSLAMS PVTLRLPRCG HHEVDHFLRE
MPALIRMACV STVAIEGTVF VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT
CGSHLTVVSL FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA
LGRLLLGKRE LGKE
