OR2Y1_HUMAN
ID OR2Y1_HUMAN Reviewed; 311 AA.
AC Q8NGV0; B9EIP1; Q6IFB1; Q96R16;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 2Y1;
DE AltName: Full=Olfactory receptor OR5-2;
GN Name=OR2Y1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-200.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-200.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2Y1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065676; BAC05901.1; -; Genomic_DNA.
DR EMBL; CH471165; EAW53748.1; -; Genomic_DNA.
DR EMBL; BC140756; AAI40757.1; -; mRNA.
DR EMBL; AF399629; AAK95114.1; -; Genomic_DNA.
DR EMBL; BK004351; DAA04749.1; -; Genomic_DNA.
DR CCDS; CCDS34323.1; -.
DR RefSeq; NP_001001657.1; NM_001001657.1.
DR AlphaFoldDB; Q8NGV0; -.
DR SMR; Q8NGV0; -.
DR STRING; 9606.ENSP00000312403; -.
DR GlyGen; Q8NGV0; 2 sites.
DR iPTMnet; Q8NGV0; -.
DR PhosphoSitePlus; Q8NGV0; -.
DR BioMuta; OR2Y1; -.
DR DMDM; 38372774; -.
DR MassIVE; Q8NGV0; -.
DR PaxDb; Q8NGV0; -.
DR PRIDE; Q8NGV0; -.
DR Antibodypedia; 29640; 98 antibodies from 21 providers.
DR DNASU; 134083; -.
DR Ensembl; ENST00000307832.3; ENSP00000312403.2; ENSG00000174339.3.
DR GeneID; 134083; -.
DR KEGG; hsa:134083; -.
DR MANE-Select; ENST00000307832.3; ENSP00000312403.2; NM_001001657.1; NP_001001657.1.
DR UCSC; uc003mmf.2; human.
DR CTD; 134083; -.
DR DisGeNET; 134083; -.
DR GeneCards; OR2Y1; -.
DR HGNC; HGNC:14837; OR2Y1.
DR HPA; ENSG00000174339; Not detected.
DR neXtProt; NX_Q8NGV0; -.
DR OpenTargets; ENSG00000174339; -.
DR PharmGKB; PA32220; -.
DR VEuPathDB; HostDB:ENSG00000174339; -.
DR eggNOG; ENOG502SI2C; Eukaryota.
DR GeneTree; ENSGT01050000244803; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGV0; -.
DR OMA; VLWRGRD; -.
DR OrthoDB; 889062at2759; -.
DR PhylomeDB; Q8NGV0; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NGV0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 134083; 5 hits in 671 CRISPR screens.
DR GeneWiki; OR2Y1; -.
DR GenomeRNAi; 134083; -.
DR Pharos; Q8NGV0; Tdark.
DR PRO; PR:Q8NGV0; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8NGV0; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 2Y1"
FT /id="PRO_0000150513"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 128
FT /note="R -> C (in dbSNP:rs11960429)"
FT /id="VAR_053162"
FT VARIANT 154
FT /note="V -> M (in dbSNP:rs11954074)"
FT /id="VAR_053163"
FT VARIANT 200
FT /note="V -> L (in dbSNP:rs10464105)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_034186"
SQ SEQUENCE 311 AA; 34731 MW; 2CD89C3B48805949 CRC64;
MGSFNTSFED GFILVGFSDW PQLEPILFVF IFIFYSLTLF GNTIIIALSW LDLRLHTPMY
FFLSHLSLLD LCFTTSTVPQ LLINLCGVDR TITRGGCVAQ LFIYLALGST ECVLLVVMAF
DRYAAVCRPL HYMAIMHPHL CQTLAIASWG AGFVNSLIQT GLAMAMPLCG HRLNHFFCEM
PVFLKLACAD TEGTEAKMFV ARVIVVAVPA ALILGSYVHI AHAVLRVKST AGRRKAFGTC
GSHLLVVFLF YGSAIYTYLQ SIHNYSEREG KFVALFYTII TPILNPLIYT LRNKDVKGAL
WKVLWRGRDS G
