OR2Z1_HUMAN
ID OR2Z1_HUMAN Reviewed; 314 AA.
AC Q8NG97; B9EH50; Q6IFK0; Q96R25;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 2Z1;
DE AltName: Full=Olfactory receptor 2Z2;
DE AltName: Full=Olfactory receptor OR19-4;
GN Name=OR2Z1; Synonyms=OR2Z2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2Z2";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065930; BAC06145.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW68902.1; -; Genomic_DNA.
DR EMBL; BC137046; AAI37047.1; -; mRNA.
DR EMBL; BC151149; AAI51150.1; -; mRNA.
DR EMBL; AF399619; AAK95104.1; -; Genomic_DNA.
DR EMBL; BK004262; DAA04660.1; -; Genomic_DNA.
DR CCDS; CCDS32895.1; -.
DR RefSeq; NP_001004699.1; NM_001004699.2.
DR AlphaFoldDB; Q8NG97; -.
DR SMR; Q8NG97; -.
DR BioGRID; 129854; 1.
DR STRING; 9606.ENSP00000316284; -.
DR GlyGen; Q8NG97; 1 site.
DR iPTMnet; Q8NG97; -.
DR PhosphoSitePlus; Q8NG97; -.
DR BioMuta; OR2Z1; -.
DR DMDM; 38372648; -.
DR MassIVE; Q8NG97; -.
DR PaxDb; Q8NG97; -.
DR PeptideAtlas; Q8NG97; -.
DR PRIDE; Q8NG97; -.
DR Antibodypedia; 53129; 87 antibodies from 22 providers.
DR DNASU; 284383; -.
DR Ensembl; ENST00000641125.1; ENSP00000493322.1; ENSG00000181733.4.
DR GeneID; 284383; -.
DR KEGG; hsa:284383; -.
DR MANE-Select; ENST00000641125.1; ENSP00000493322.1; NM_001004699.3; NP_001004699.1.
DR UCSC; uc010xkg.3; human.
DR CTD; 284383; -.
DR GeneCards; OR2Z1; -.
DR HGNC; HGNC:15391; OR2Z1.
DR HPA; ENSG00000181733; Not detected.
DR neXtProt; NX_Q8NG97; -.
DR OpenTargets; ENSG00000181733; -.
DR PharmGKB; PA32221; -.
DR VEuPathDB; HostDB:ENSG00000181733; -.
DR eggNOG; ENOG502SMQD; Eukaryota.
DR GeneTree; ENSGT01050000244863; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NG97; -.
DR OMA; FLTMMGV; -.
DR OrthoDB; 1080357at2759; -.
DR PhylomeDB; Q8NG97; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NG97; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 284383; 14 hits in 669 CRISPR screens.
DR ChiTaRS; OR2Z1; human.
DR GeneWiki; OR2Z1; -.
DR GenomeRNAi; 284383; -.
DR Pharos; Q8NG97; Tdark.
DR PRO; PR:Q8NG97; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NG97; protein.
DR ExpressionAtlas; Q8NG97; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 2Z1"
FT /id="PRO_0000150514"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 138
FT /note="R -> C (in dbSNP:rs58741481)"
FT /id="VAR_062031"
SQ SEQUENCE 314 AA; 34444 MW; 537E389A5EDA471F CRC64;
MGDVNQSVAS DFILVGLFSH SGSRQLLFSL VAVMFVIGLL GNTVLLFLIR VDSRLHTPMY
FLLSQLSLFD IGCPMVTIPK MASDFLRGEG ATSYGGGAAQ IFFLTLMGVA EGVLLVLMSY
DRYVAVCQPL QYPVLMRRQV CLLMMGSSWV VGVLNASIQT SITLHFPYCA SRIVDHFFCE
VPALLKLSCA DTCAYEMALS TSGVLILMLP LSLIATSYGH VLQAVLSMRS EEARHKAVTT
CSSHITVVGL FYGAAVFMYM VPCAYHSPQQ DNVVSLFYSL VTPTLNPLIY SLRNPEVWMA
LVKVLSRAGL RQMC
