OR2_ANOGA
ID OR2_ANOGA Reviewed; 378 AA.
AC Q8WTE6; B5U0U8; Q7QG59;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Odorant receptor Or2;
DE AltName: Full=AgOr2;
GN Name=OR2; ORFNames=AGAP009519;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000312|EMBL:AAL35507.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=G3 {ECO:0000269|PubMed:11724964};
RX PubMed=11724964; DOI=10.1073/pnas.261432998;
RA Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.;
RT "Candidate odorant receptors from the malaria vector mosquito Anopheles
RT gambiae and evidence of down-regulation in response to blood feeding.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001).
RN [2] {ECO:0000312|EMBL:EAA05926.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Suakoko;
RA Bohbot J.D., Zwiebel L.J., Wang G.;
RT "Anopheles gambiae (Suakoko strain) odorant receptor 2 gene (AgOr2).";
RL Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [4] {ECO:0000305}
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=12364795; DOI=10.1126/science.1076196;
RA Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A.,
RA Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J.;
RT "G protein-coupled receptors in Anopheles gambiae.";
RL Science 298:176-178(2002).
RN [5] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=14724626; DOI=10.1038/427212a;
RA Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.;
RT "Olfaction: mosquito receptor for human-sweat odorant.";
RL Nature 427:212-213(2004).
CC -!- FUNCTION: Odorant receptor which plays a critical role in the
CC anthropophilic host-seeking behavior; establishes the host preference
CC to transmit malaria. {ECO:0000269|PubMed:11724964,
CC ECO:0000269|PubMed:14724626}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in male and female antennae and maxillary
CC palps. {ECO:0000269|PubMed:11724964, ECO:0000269|PubMed:12364795}.
CC -!- INDUCTION: Strong response to the odorant 2-methylphenol when expressed
CC in odorant receptor deficient Drosophila.
CC {ECO:0000269|PubMed:14724626}.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or30a
CC subfamily. {ECO:0000305}.
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DR EMBL; AF364131; AAL35507.1; -; Genomic_DNA.
DR EMBL; FJ154789; ACH95386.1; -; mRNA.
DR EMBL; AAAB01008839; EAA05926.1; -; Genomic_DNA.
DR RefSeq; XP_310173.1; XM_310173.1.
DR AlphaFoldDB; Q8WTE6; -.
DR SMR; Q8WTE6; -.
DR STRING; 7165.AGAP009519-PA; -.
DR TCDB; 1.A.69.1.2; the heteromeric odorant receptor channel (horc) family.
DR PaxDb; Q8WTE6; -.
DR GeneID; 1271390; -.
DR KEGG; aga:AgaP_AGAP009519; -.
DR CTD; 1271390; -.
DR VEuPathDB; VectorBase:AGAP009519; -.
DR eggNOG; ENOG502STCD; Eukaryota.
DR InParanoid; Q8WTE6; -.
DR OMA; PACCMYI; -.
DR OrthoDB; 745330at2759; -.
DR PhylomeDB; Q8WTE6; -.
DR Proteomes; UP000007062; Chromosome 3R.
DR GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; IDA:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR GO; GO:0042048; P:olfactory behavior; IDA:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..378
FT /note="Odorant receptor Or2"
FT /id="PRO_0000174287"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..254
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..378
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 378 AA; 43502 MW; 17BAD2574BDE20BF CRC64;
MLIEECPIIG VNVRVWLFWS YLRRPRLSRF LVGCIPVAVL NVFQFLKLYS SWGDMSELII
NGYFTVLYFN LVLRTSFLVI NRRKFETFFE GVAAEYALLE KNDDIRPVLE RYTRRGRMLS
ISNLWLGAFI SACFVTYPLF VPGRGLPYGV TIPGVDVLAT PTYQVVFVLQ VYLTFPACCM
YIPFTSFYAT CTLFALVQIA ALKQRLGRLG RHSGTMASTG HSAGTLFAEL KECLKYHKQI
IQYVHDLNSL VTHLCLLEFL SFGMMLCALL FLLSISNQLA QMIMIGSYIF MILSQMFAFY
WHANEVLEQS LGIGDAIYNG AWPDFEEPIR KRLILIIARA QRPMVIKVGN VYPMTLEMFQ
KLLNVSYSYF TLLRRVYN
