ID   ASA1_VANPO              Reviewed;         461 AA.
AC   A7TKC6;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=ASTRA-associated protein 1;
GN   Name=ASA1; ORFNames=Kpol_538p13;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC       remodeling. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the ASTRA chromatin remodeling machinery complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
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DR   EMBL; DS480407; EDO17253.1; -; Genomic_DNA.
DR   RefSeq; XP_001645111.1; XM_001645061.1.
DR   AlphaFoldDB; A7TKC6; -.
DR   STRING; 436907.A7TKC6; -.
DR   EnsemblFungi; EDO17253; EDO17253; Kpol_538p13.
DR   GeneID; 5545459; -.
DR   KEGG; vpo:Kpol_538p13; -.
DR   eggNOG; ENOG502QU4T; Eukaryota.
DR   HOGENOM; CLU_045414_1_0_1; -.
DR   InParanoid; A7TKC6; -.
DR   OMA; LVCCNTQ; -.
DR   OrthoDB; 1543596at2759; -.
DR   PhylomeDB; A7TKC6; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..461
FT                   /note="ASTRA-associated protein 1"
FT                   /id="PRO_0000402222"
FT   REPEAT          14..58
FT                   /note="WD 1"
FT   REPEAT          84..123
FT                   /note="WD 2"
FT   REPEAT          224..268
FT                   /note="WD 3"
FT   REPEAT          271..311
FT                   /note="WD 4"
SQ   SEQUENCE   461 AA;  51901 MW;  AF84B15B0A627599 CRC64;
     MATKVTLSEY TLRFHKDAVT DVKTVVDLTN FKVPVLISGD GSGKLVIWNV ITRRVQFVYE
     IPKSPQILAI EYLGDLLVAV LSKDHKLRIL QLQLDESKTL VKTNEQSQIQ QQLYKYNIVF
     EVPVNTLNFA NFSLEKIAPE EYRLVCCNTQ NAESIDIYAF KLNRLNSLKR LNKGINFYKT
     VIDLLRNTEI SKFDKLGIVM KFLRVNDLVY CGFESGIIIC FRYKLRQEVM TTKYNETSSK
     QSKLQELIKS EDTDISIYEN MLEIVYISTV HYPNPILDLS ISAKDEETVL SSSTDSKIGI
     HKAQITNGNV SLPDNEGYII DDSKQVIVRK TLGADTSFVE VPVTEIGSIK SLKCGMVLGG
     WNGKAIVVDN NNEILKIVGR TKSNILVNES AIRSIQNDSD SIIKMKKNYK IKAVDGIDGV
     GTDISQLSNI SRGDQRRLDK FLSSSWCIVG FDDGCITLDS I