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OR33C_DROME
ID   OR33C_DROME             Reviewed;         384 AA.
AC   P81916;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1999, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Odorant receptor 33c;
GN   Name=Or33c; Synonyms=AN2, DOR33B.3, dor71, Or33B.3; ORFNames=CG5006;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10458908; DOI=10.1006/geno.1999.5894;
RA   Gao Q., Chess A.;
RT   "Identification of candidate Drosophila olfactory receptors from genomic
RT   DNA sequence.";
RL   Genomics 60:31-39(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=10069338; DOI=10.1016/s0896-6273(00)81093-4;
RA   Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., Carlson J.R.;
RT   "A novel family of divergent seven-transmembrane proteins: candidate
RT   odorant receptors in Drosophila.";
RL   Neuron 22:327-338(1999).
RN   [5]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RC   STRAIN=Oregon-R; TISSUE=Antenna;
RX   PubMed=10089887; DOI=10.1016/s0092-8674(00)80582-6;
RA   Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
RT   "A spatial map of olfactory receptor expression in the Drosophila
RT   antenna.";
RL   Cell 96:725-736(1999).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA   Vosshall L.B., Wong A.M., Axel R.;
RT   "An olfactory sensory map in the fly brain.";
RL   Cell 102:147-159(2000).
CC   -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC       behavior, depending on its substrates. The odorant receptor repertoire
CC       encodes a large collection of odor stimuli that vary widely in
CC       identity, intensity, and duration. May form a complex with Orco to form
CC       odorant-sensing units, providing sensitive and prolonged odorant
CC       signaling and calcium permeability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Orco. Complexes exist early in the endomembrane
CC       system in olfactory sensory neurons (OSNs), coupling these complexes to
CC       the conserved ciliary trafficking pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the antenna and in a subset of 18
CC       olfactory receptor neurons in the maxillary palp.
CC       {ECO:0000269|PubMed:10069338, ECO:0000269|PubMed:10089887,
CC       ECO:0000269|PubMed:10943836}.
CC   -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC       odorant receptors appears to be an insect-specific solution for odor
CC       recognition, making the OR/Orco complex an attractive target for the
CC       development of highly selective insect repellents to disrupt olfactory-
CC       mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC       OR currents are independent of known G-protein-coupled second messenger
CC       pathways.
CC   -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC       Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE014134; AAF53133.1; -; Genomic_DNA.
DR   RefSeq; NP_523555.1; NM_078831.1.
DR   AlphaFoldDB; P81916; -.
DR   SMR; P81916; -.
DR   STRING; 7227.FBpp0079864; -.
DR   PaxDb; P81916; -.
DR   EnsemblMetazoa; FBtr0080280; FBpp0079864; FBgn0026390.
DR   GeneID; 34603; -.
DR   KEGG; dme:Dmel_CG5006; -.
DR   CTD; 34603; -.
DR   FlyBase; FBgn0026390; Or33c.
DR   VEuPathDB; VectorBase:FBgn0026390; -.
DR   eggNOG; ENOG502TBPZ; Eukaryota.
DR   GeneTree; ENSGT00540000073151; -.
DR   HOGENOM; CLU_033399_8_1_1; -.
DR   InParanoid; P81916; -.
DR   OMA; YYLVFFG; -.
DR   OrthoDB; 745330at2759; -.
DR   PhylomeDB; P81916; -.
DR   BioGRID-ORCS; 34603; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 34603; -.
DR   PRO; PR:P81916; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0026390; Expressed in maxillary palp olfactory receptor neuron (Drosophila) and 2 other tissues.
DR   Genevisible; P81916; DM.
DR   GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
DR   GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:FlyBase.
DR   GO; GO:0007608; P:sensory perception of smell; IEP:FlyBase.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004117; 7tm6_olfct_rcpt.
DR   PANTHER; PTHR21137; PTHR21137; 1.
DR   Pfam; PF02949; 7tm_6; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Olfaction; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..384
FT                   /note="Odorant receptor 33c"
FT                   /id="PRO_0000174240"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..63
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..169
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..251
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        273..274
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..379
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        380..384
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   384 AA;  44374 MW;  9F71EEC446BDAAE6 CRC64;
     MVIIDSLSFY RPFWICMRLL VPTFFKDSSR PVQLYVVLLH ILVTLWFPLH LLLHLLLLPS
     TAEFFKNLTM SLTCVACSLK HVAHLYHLPQ IVEIESLIEQ LDTFIASEQE HRYYRDHVHC
     HARRFTRCLY ISFGMIYALF LFGVFVQVIS GNWELLYPAY FPFDLESNRF LGAVALGYQV
     FSMLVEGFQG LGNDTYTPLT LCLLAGHVHL WSIRMGQLGY FDDETVVNHQ RLLDYIEQHK
     LLVRFHNLVS RTISEVQLVQ LGGCGATLCI IVSYMLFFVG DTISLVYYLV FFGVVCVQLF
     PSCYFASEVA EELERLPYAI FSSRWYDQSR DHRFDLLIFT QLTLGNRGWI IKAGGLIELN
     LNAFFATLKM AYSLFAVVVR AKGI
 
 
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