OR3A1_HUMAN
ID OR3A1_HUMAN Reviewed; 315 AA.
AC P47881; Q4VB06; Q6IFM4;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Olfactory receptor 3A1;
DE AltName: Full=Olfactory receptor 17-40;
DE Short=OR17-40;
DE AltName: Full=Olfactory receptor OR17-15;
GN Name=OR3A1; Synonyms=OLFRA03;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-125.
RX PubMed=8647456; DOI=10.1016/0378-1119(95)00849-7;
RA Crowe M.L., Perry B.N., Connerton I.F.;
RT "Olfactory receptor-encoding genes and pseudogenes are expressed in
RT humans.";
RL Gene 169:247-249(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8921386; DOI=10.1006/geno.1996.0536;
RA Glusman G., Clifton S., Roe B., Lancet D.;
RT "Sequence analysis in the olfactory receptor gene cluster on human
RT chromosome 17: recombinatorial events affecting receptor diversity.";
RL Genomics 37:147-160(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-125.
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-125.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, AND VARIANT GLN-125.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [7]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [8]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR3A1/term:OR3A1/type:keyword";
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DR EMBL; X80391; CAA56602.1; -; Genomic_DNA.
DR EMBL; U58675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF087924; AAF37314.1; -; Genomic_DNA.
DR EMBL; AC087498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069414; AAH69414.1; -; mRNA.
DR EMBL; BC096187; AAH96187.1; -; mRNA.
DR EMBL; BC096188; AAH96188.1; -; mRNA.
DR EMBL; BC096189; AAH96189.1; -; mRNA.
DR EMBL; BC096190; AAH96190.1; -; mRNA.
DR EMBL; U04683; AAA18347.1; -; Genomic_DNA.
DR EMBL; BK004238; DAA04636.1; -; Genomic_DNA.
DR CCDS; CCDS11023.1; -.
DR PIR; I38476; I38476.
DR PIR; JC4658; JC4658.
DR RefSeq; NP_002541.2; NM_002550.2.
DR RefSeq; XP_016880184.1; XM_017024695.1.
DR RefSeq; XP_016880185.1; XM_017024696.1.
DR AlphaFoldDB; P47881; -.
DR SMR; P47881; -.
DR BioGRID; 111038; 3.
DR IntAct; P47881; 1.
DR MINT; P47881; -.
DR STRING; 9606.ENSP00000313803; -.
DR GlyGen; P47881; 1 site.
DR iPTMnet; P47881; -.
DR PhosphoSitePlus; P47881; -.
DR BioMuta; OR3A1; -.
DR DMDM; 148880124; -.
DR PaxDb; P47881; -.
DR PeptideAtlas; P47881; -.
DR PRIDE; P47881; -.
DR Antibodypedia; 52931; 55 antibodies from 14 providers.
DR DNASU; 4994; -.
DR Ensembl; ENST00000323404.2; ENSP00000313803.1; ENSG00000180090.5.
DR GeneID; 4994; -.
DR KEGG; hsa:4994; -.
DR MANE-Select; ENST00000323404.2; ENSP00000313803.1; NM_002550.3; NP_002541.2.
DR UCSC; uc002fvh.1; human.
DR CTD; 4994; -.
DR GeneCards; OR3A1; -.
DR HGNC; HGNC:8282; OR3A1.
DR HPA; ENSG00000180090; Not detected.
DR neXtProt; NX_P47881; -.
DR OpenTargets; ENSG00000180090; -.
DR PharmGKB; PA32223; -.
DR VEuPathDB; HostDB:ENSG00000180090; -.
DR eggNOG; ENOG502RU17; Eukaryota.
DR GeneTree; ENSGT00940000162835; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; P47881; -.
DR OrthoDB; 866197at2759; -.
DR PhylomeDB; P47881; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; P47881; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; P47881; -.
DR BioGRID-ORCS; 4994; 6 hits in 676 CRISPR screens.
DR GeneWiki; OR3A1; -.
DR GenomeRNAi; 4994; -.
DR Pharos; P47881; Tdark.
DR PRO; PR:P47881; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P47881; protein.
DR Bgee; ENSG00000180090; Expressed in secondary oocyte and 9 other tissues.
DR ExpressionAtlas; P47881; baseline and differential.
DR Genevisible; P47881; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 3A1"
FT /id="PRO_0000150515"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 78
FT /note="S -> G (in dbSNP:rs16952828)"
FT /id="VAR_057542"
FT VARIANT 125
FT /note="R -> Q (in dbSNP:rs703903)"
FT /evidence="ECO:0000269|PubMed:10673334,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:8004088,
FT ECO:0000269|PubMed:8647456"
FT /id="VAR_012059"
FT CONFLICT 120
FT /note="A -> D (in Ref. 6; AAA18347)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 34609 MW; DF32977D5EA7D7CA CRC64;
MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT
PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC LTQLFFFHLF VGVDCFLLTA
MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF
YCDLPQLFQL SCSSTQLNEL LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA
FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV
QSAIWRMLTG RRSLA
