OR3A2_HUMAN
ID OR3A2_HUMAN Reviewed; 321 AA.
AC P47893; Q6IFM3; Q9P1Q3;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 3.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Olfactory receptor 3A2;
DE AltName: Full=Olfactory receptor 17-228;
DE Short=OR17-228;
DE AltName: Full=Olfactory receptor OR17-14;
GN Name=OR3A2; Synonyms=OLFRA04;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-321.
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-321.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR3A2";
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DR EMBL; AC087498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC095517; AAH95517.1; -; mRNA.
DR EMBL; AF087930; AAF37318.1; -; Genomic_DNA.
DR EMBL; U04713; AAA17448.1; -; Genomic_DNA.
DR EMBL; BK004239; DAA04637.1; -; Genomic_DNA.
DR PIR; I38484; I38484.
DR RefSeq; NP_002542.3; NM_002551.3.
DR AlphaFoldDB; P47893; -.
DR SMR; P47893; -.
DR BioGRID; 111039; 2.
DR IntAct; P47893; 1.
DR STRING; 9606.ENSP00000386180; -.
DR GlyGen; P47893; 1 site.
DR iPTMnet; P47893; -.
DR PhosphoSitePlus; P47893; -.
DR BioMuta; OR3A2; -.
DR DMDM; 226694173; -.
DR MassIVE; P47893; -.
DR PaxDb; P47893; -.
DR PeptideAtlas; P47893; -.
DR PRIDE; P47893; -.
DR Antibodypedia; 62122; 56 antibodies from 17 providers.
DR DNASU; 4995; -.
DR GeneID; 4995; -.
DR KEGG; hsa:4995; -.
DR UCSC; uc002fvg.4; human.
DR CTD; 4995; -.
DR DisGeNET; 4995; -.
DR GeneCards; OR3A2; -.
DR HGNC; HGNC:8283; OR3A2.
DR HPA; ENSG00000221882; Group enriched (brain, retina, testis).
DR neXtProt; NX_P47893; -.
DR PharmGKB; PA32224; -.
DR VEuPathDB; HostDB:ENSG00000221882; -.
DR eggNOG; ENOG502RU1B; Eukaryota.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; P47893; -.
DR OrthoDB; 866197at2759; -.
DR PhylomeDB; P47893; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; P47893; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; P47893; -.
DR BioGRID-ORCS; 4995; 12 hits in 637 CRISPR screens.
DR ChiTaRS; OR3A2; human.
DR GeneWiki; OR3A2; -.
DR GenomeRNAi; 4995; -.
DR Pharos; P47893; Tdark.
DR PRO; PR:P47893; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P47893; protein.
DR Genevisible; P47893; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 3A2"
FT /id="PRO_0000150518"
FT TOPO_DOM 1..35
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 190
FT /note="L -> V (in dbSNP:rs9901356)"
FT /id="VAR_062032"
FT CONFLICT 128
FT /note="A -> G (in Ref. 4; AAA17448)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="A -> G (in Ref. 4; AAA17448)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="S -> R (in Ref. 4; AAA17448)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="A -> G (in Ref. 4; AAA17448)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 35207 MW; 642FCD0CC1660F8A CRC64;
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV
EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD
CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASLAC AFTNALTHTV AMSTLNFCGP
NEVNHFYCDL PQLFQLSCSS TQLNELLLFA VGFIMAGTPL VLIITAYSHV AAAVLRIRSV
EGRKKAFSTC GSHLTVVCLF FGRGIFNYMR LGSEEASDKD KGVGVFNTVI NPMLNPLIYS
LRNPDVQGAL WQIFLGRRSL T
