OR3A3_HUMAN
ID OR3A3_HUMAN Reviewed; 321 AA.
AC P47888; Q2VPE4; Q6IFM6; Q9P1Q4; Q9UBE7;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 3.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Olfactory receptor 3A3;
DE AltName: Full=Olfactory receptor 17-201;
DE Short=OR17-201;
DE AltName: Full=Olfactory receptor 3A6;
DE AltName: Full=Olfactory receptor 3A7;
DE AltName: Full=Olfactory receptor 3A8;
DE AltName: Full=Olfactory receptor OR17-22;
GN Name=OR3A3; Synonyms=OR3A6, OR3A7, OR3A8P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
RX PubMed=10673334; DOI=10.1006/geno.1999.6030;
RA Glusman G., Sosinsky A., Ben-Asher E., Avidan N., Sonkin D., Bahar A.,
RA Rosenthal A., Clifton S., Roe B., Ferraz C., Demaille J.G., Lancet D.;
RT "Sequence, structure, and evolution of a complete human olfactory receptor
RT gene cluster.";
RL Genomics 63:227-245(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
RA Ferraz C., Vidal S., Brun C., Demaille J.G.;
RT "DNA sequence of PAC clone PAC_clone_LLNLP704E02527Q3 from the olfactory
RT receptor gene cluster of human chromosome 17p13.3, containing OR genes 2,
RT 201, 93 and pseudogene 1.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
RA Ferraz C., Demaille J.G.;
RT "Sequence of cosmid ICRF105cH07155 of the olfactory receptor gene cluster
RT of human chromosome 17p13.3.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLU-317.
RA Ferraz C., Demaille J.G.;
RT "Sequence of cosmid ICRF105cE06173 of human chromosome 17p13.3 olfactory
RT receptor gene cluster, containing genes OR17-32 and OR17-201-1, and
RT pseudogene OR17-01.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-317.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-292.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-292.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [9]
RP IDENTIFICATION, AND VARIANT GLU-317.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [10]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI08922.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR3A3";
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DR EMBL; AC007194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF087926; AAF37316.1; -; Genomic_DNA.
DR EMBL; AF095725; AAF03262.1; -; Genomic_DNA.
DR EMBL; U76377; AAD00250.1; -; Genomic_DNA.
DR EMBL; U78308; AAD00277.1; -; Genomic_DNA.
DR EMBL; AC025125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069415; AAH69415.1; -; mRNA.
DR EMBL; BC108921; AAI08922.2; ALT_INIT; mRNA.
DR EMBL; U04688; AAA18351.1; -; Genomic_DNA.
DR EMBL; AF399620; AAK95105.1; -; Genomic_DNA.
DR EMBL; BK004236; DAA04634.1; -; Genomic_DNA.
DR PIR; I38480; I38480.
DR RefSeq; NP_036505.2; NM_012373.2.
DR AlphaFoldDB; P47888; -.
DR SMR; P47888; -.
DR STRING; 9606.ENSP00000291231; -.
DR GlyGen; P47888; 1 site.
DR iPTMnet; P47888; -.
DR PhosphoSitePlus; P47888; -.
DR BioMuta; OR3A3; -.
DR DMDM; 226694174; -.
DR MassIVE; P47888; -.
DR PaxDb; P47888; -.
DR PeptideAtlas; P47888; -.
DR PRIDE; P47888; -.
DR Antibodypedia; 23008; 82 antibodies from 18 providers.
DR DNASU; 8392; -.
DR GeneID; 8392; -.
DR KEGG; hsa:8392; -.
DR UCSC; uc010vrd.2; human.
DR CTD; 8392; -.
DR GeneCards; OR3A3; -.
DR HGNC; HGNC:8284; OR3A3.
DR HPA; ENSG00000159961; Not detected.
DR neXtProt; NX_P47888; -.
DR PharmGKB; PA32225; -.
DR VEuPathDB; HostDB:ENSG00000159961; -.
DR eggNOG; ENOG502RU1B; Eukaryota.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; P47888; -.
DR OrthoDB; 866197at2759; -.
DR PhylomeDB; P47888; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; P47888; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 8392; 27 hits in 621 CRISPR screens.
DR ChiTaRS; OR3A3; human.
DR GeneWiki; OR3A3; -.
DR GenomeRNAi; 8392; -.
DR Pharos; P47888; Tdark.
DR PRO; PR:P47888; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P47888; protein.
DR Genevisible; P47888; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 3A3"
FT /id="PRO_0000150520"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 132
FT /note="L -> F (in dbSNP:rs769432)"
FT /id="VAR_054961"
FT VARIANT 158
FT /note="W -> L (in dbSNP:rs916039)"
FT /id="VAR_054962"
FT VARIANT 287
FT /note="M -> V (in dbSNP:rs12939997)"
FT /id="VAR_054963"
FT VARIANT 317
FT /note="K -> E (in dbSNP:rs227787)"
FT /evidence="ECO:0000269|PubMed:10673334,
FT ECO:0000269|PubMed:14983052, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.2, ECO:0000269|Ref.3, ECO:0000269|Ref.4"
FT /id="VAR_054964"
FT CONFLICT 48
FT /note="T -> I (in Ref. 1; AAF37316/AC007194, 2; AAF03262,
FT 3; AAD00250, 4; AAD00277 and 6; AAH69415)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="A -> G (in Ref. 7; AAA18351)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="D -> E (in Ref. 7; AAA18351)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="L -> V (in Ref. 7; AAA18351)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 34963 MW; DA67FD99DE730A66 CRC64;
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV
EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD
CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASWAC AFTNALTHTV AMSTLNFCGP
NEVNHFYCDL PQLFQLSCSS TQLNELLLFV AAAFMAVAPL VFISVSYAHV VAAVLQIRSA
EGRKKAFSTC GSHLTVVGIF YGTGVFSYMR LGSVESSDKD KGVGVFMTVI NPMLNPLIYS
LRNTDVQGAL CQLLVGKRSL T
