OR3A4_HUMAN
ID OR3A4_HUMAN Reviewed; 348 AA.
AC P47883; Q96R24;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 4.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Putative olfactory receptor 3A4;
DE AltName: Full=Olfactory receptor 17-24;
DE Short=OR17-24;
DE AltName: Full=Olfactory receptor 3A5;
GN Name=OR3A4P; Synonyms=OR3A4, OR3A5P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, AND VARIANTS ALA-193 AND
RP LYS-237.
RX PubMed=8004088; DOI=10.1093/hmg/3.2.229;
RA Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter D.H.,
RA Carrozzo R., Patel K., Sheer D., Lehrach H., North M.A.;
RT "Olfactory receptor gene cluster on human chromosome 17: possible
RT duplication of an ancestral receptor repertoire.";
RL Hum. Mol. Genet. 3:229-235(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 71-286, AND VARIANTS ALA-193 AND
RP LYS-237.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR3A4";
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DR EMBL; AC087498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136874; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; U04680; AAA18344.1; -; Genomic_DNA.
DR EMBL; AF399621; AAK95106.1; -; Genomic_DNA.
DR PIR; I38472; I38472.
DR AlphaFoldDB; P47883; -.
DR SMR; P47883; -.
DR GlyGen; P47883; 1 site.
DR BioMuta; HGNC:15510; -.
DR DMDM; 269849760; -.
DR PeptideAtlas; P47883; -.
DR PRIDE; P47883; -.
DR ProteomicsDB; 55809; -.
DR GeneCards; OR3A4P; -.
DR HGNC; HGNC:15510; OR3A4P.
DR neXtProt; NX_P47883; -.
DR InParanoid; P47883; -.
DR PhylomeDB; P47883; -.
DR PathwayCommons; P47883; -.
DR Pharos; P47883; Tdark.
DR PRO; PR:P47883; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P47883; protein.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..348
FT /note="Putative olfactory receptor 3A4"
FT /id="PRO_0000150522"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 42
FT /note="I -> V (in dbSNP:rs9905684)"
FT /id="VAR_060594"
FT VARIANT 86
FT /note="S -> R (in dbSNP:rs9905086)"
FT /id="VAR_060595"
FT VARIANT 103
FT /note="E -> Q (in dbSNP:rs9903671)"
FT /id="VAR_060596"
FT VARIANT 120
FT /note="I -> V (in dbSNP:rs9906179)"
FT /id="VAR_060597"
FT VARIANT 168
FT /note="P -> T (in dbSNP:rs9911226)"
FT /id="VAR_060598"
FT VARIANT 175
FT /note="N -> S (in dbSNP:rs9912090)"
FT /id="VAR_060599"
FT VARIANT 181
FT /note="Y -> H (in dbSNP:rs2855677)"
FT /id="VAR_060600"
FT VARIANT 193
FT /note="S -> A (in dbSNP:rs231678)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:8004088"
FT /id="VAR_060601"
FT VARIANT 237
FT /note="R -> K (in dbSNP:rs231677)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:8004088"
FT /id="VAR_060602"
FT VARIANT 300
FT /note="V -> I (in dbSNP:rs8076130)"
FT /id="VAR_060603"
SQ SEQUENCE 348 AA; 37194 MW; 9F04037E0F2690F4 CRC64;
MDLGNSGNDS VVTKFVLLGL TETAALQPIL FVIFLLAYVT TIGGTLSILA AILMETKLHS
PMYFFLGNLS LPDVGCVSVT VPAMLSHFIS NDRSIPYKAC LSELFFFHLL AGADCFLLTI
MAYDRYLAIC QSLTYSSRMS WGIQQALVGM SCVFSFTNAL TQTVALSPLN FCGPNVINHF
YCDLPQPFQL SCSSVHLNGQ LLFVAAAFMG VAPLVLITVS YAHVAAAVLR IRSAEGRKKA
FSTCSSHLTV VGIFYGTGVF SYTRLGSVES SDKDKGIGIL NTVISPMLNP LIYWTSLLDV
GCISHCSSDA GVSPGPPVQS SLCCLQFTAL LSPPPGWGGL SPLNSHGL
