OR4A5_HUMAN
ID OR4A5_HUMAN Reviewed; 315 AA.
AC Q8NH83; Q6IF84;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 4.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 4A5;
DE AltName: Full=Olfactory receptor OR11-111;
GN Name=OR4A5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4A5";
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DR EMBL; AB065506; BAC05754.1; -; Genomic_DNA.
DR EMBL; AC087377; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004378; DAA04776.1; -; Genomic_DNA.
DR CCDS; CCDS73289.1; -.
DR RefSeq; NP_001005272.3; NM_001005272.3.
DR AlphaFoldDB; Q8NH83; -.
DR SMR; Q8NH83; -.
DR STRING; 9606.ENSP00000367664; -.
DR GlyGen; Q8NH83; 1 site.
DR iPTMnet; Q8NH83; -.
DR PhosphoSitePlus; Q8NH83; -.
DR BioMuta; OR4A5; -.
DR DMDM; 327478606; -.
DR MassIVE; Q8NH83; -.
DR PaxDb; Q8NH83; -.
DR PeptideAtlas; Q8NH83; -.
DR PRIDE; Q8NH83; -.
DR ProteomicsDB; 73683; -.
DR Antibodypedia; 27099; 17 antibodies from 9 providers.
DR DNASU; 81318; -.
DR Ensembl; ENST00000319760.8; ENSP00000367664.2; ENSG00000221840.4.
DR GeneID; 81318; -.
DR KEGG; hsa:81318; -.
DR MANE-Select; ENST00000319760.8; ENSP00000367664.2; NM_001005272.3; NP_001005272.3.
DR UCSC; uc001nhi.3; human.
DR CTD; 81318; -.
DR DisGeNET; 81318; -.
DR GeneCards; OR4A5; -.
DR HGNC; HGNC:15162; OR4A5.
DR HPA; ENSG00000221840; Not detected.
DR neXtProt; NX_Q8NH83; -.
DR OpenTargets; ENSG00000221840; -.
DR VEuPathDB; HostDB:ENSG00000221840; -.
DR eggNOG; ENOG502SJPV; Eukaryota.
DR GeneTree; ENSGT00940000155775; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH83; -.
DR OMA; MRQKNNI; -.
DR OrthoDB; 965113at2759; -.
DR PhylomeDB; Q8NH83; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NH83; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81318; 15 hits in 608 CRISPR screens.
DR GeneWiki; OR4A5; -.
DR GenomeRNAi; 81318; -.
DR Pharos; Q8NH83; Tdark.
DR PRO; PR:Q8NH83; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH83; protein.
DR ExpressionAtlas; Q8NH83; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 4A5"
FT /id="PRO_0000150524"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..286
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 6
FT /note="N -> S (in dbSNP:rs10902343)"
FT /id="VAR_031741"
FT VARIANT 23
FT /note="K -> N (in dbSNP:rs56302591)"
FT /id="VAR_062033"
FT VARIANT 219
FT /note="L -> Q (in dbSNP:rs35083184)"
FT /id="VAR_062034"
FT CONFLICT 16
FT /note="S -> F (in Ref. 1; BAC05754)"
FT /evidence="ECO:0000305"
FT CONFLICT 48..49
FT /note="IA -> FS (in Ref. 1; BAC05754)"
FT /evidence="ECO:0000305"
FT CONFLICT 54..56
FT /note="GSP -> CSA (in Ref. 1; BAC05754)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 34915 MW; E0659F90F54E9921 CRC64;
MRQNNNITEF VLLGFSQDPG VQKALFVMFL LTYLVTVVGN LLIVVDIIAS PSLGSPMYFF
LACLSFIDAA YSTTISPKLI VGLFCDKKTI SFQGCMGQLF IDHFFGGAEV FLLVVMACDR
YVAICKPLHY LTIMNRQVCF LLLVVAMIGG FVHSAFQIVV YSLPFCGPNV IVHFSCDMHP
LLELACTDTY FIGLTVVVNS GAICMVIFNL LLISYGVILS SLKTYSQEKR GKALSTCSSG
STVVVLFFVP CIFIYVRPVS NFPTDKFMTV FYTIITHMLS PLIYTLRNSE MRNAIEKLLG
KKLTIFIIGG VSVLM
