OR4B1_HUMAN
ID OR4B1_HUMAN Reviewed; 309 AA.
AC Q8NGF8; Q6IF75; Q96R64;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 4B1;
DE AltName: Full=OST208;
DE AltName: Full=Olfactory receptor OR11-106;
GN Name=OR4B1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-278.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR4B1/term:OR4B1/type:keyword";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065848; BAC06066.1; -; Genomic_DNA.
DR EMBL; AF399579; AAK95064.1; -; Genomic_DNA.
DR EMBL; BK004387; DAA04785.1; -; Genomic_DNA.
DR CCDS; CCDS31485.1; -.
DR RefSeq; NP_001005470.1; NM_001005470.1.
DR AlphaFoldDB; Q8NGF8; -.
DR SMR; Q8NGF8; -.
DR BioGRID; 125660; 1.
DR STRING; 9606.ENSP00000311605; -.
DR GlyGen; Q8NGF8; 1 site.
DR BioMuta; OR4B1; -.
DR DMDM; 38372682; -.
DR PaxDb; Q8NGF8; -.
DR PeptideAtlas; Q8NGF8; -.
DR PRIDE; Q8NGF8; -.
DR Antibodypedia; 26973; 38 antibodies from 15 providers.
DR DNASU; 119765; -.
DR Ensembl; ENST00000309562.3; ENSP00000311605.2; ENSG00000175619.3.
DR GeneID; 119765; -.
DR KEGG; hsa:119765; -.
DR MANE-Select; ENST00000309562.3; ENSP00000311605.2; NM_001005470.1; NP_001005470.1.
DR UCSC; uc010rhs.3; human.
DR CTD; 119765; -.
DR GeneCards; OR4B1; -.
DR HGNC; HGNC:8290; OR4B1.
DR HPA; ENSG00000175619; Not detected.
DR neXtProt; NX_Q8NGF8; -.
DR OpenTargets; ENSG00000175619; -.
DR PharmGKB; PA32250; -.
DR VEuPathDB; HostDB:ENSG00000175619; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000155395; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGF8; -.
DR OMA; HYMNIIS; -.
DR OrthoDB; 1082090at2759; -.
DR PhylomeDB; Q8NGF8; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NGF8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 119765; 13 hits in 670 CRISPR screens.
DR GeneWiki; OR4B1; -.
DR GenomeRNAi; 119765; -.
DR Pharos; Q8NGF8; Tdark.
DR PRO; PR:Q8NGF8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGF8; protein.
DR ExpressionAtlas; Q8NGF8; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 4B1"
FT /id="PRO_0000150528"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 63
FT /note="C -> Y (in dbSNP:rs11606506)"
FT /id="VAR_034189"
FT VARIANT 237
FT /note="T -> N (in dbSNP:rs12292056)"
FT /id="VAR_034190"
SQ SEQUENCE 309 AA; 34456 MW; AD37FF9C88549964 CRC64;
MASTSNVTEL IFTGLFQDPA VQSVCFVVFL PVYLATVVGN GLIVLTVSIS KSLDSPMYFF
LSCLSLVEIS YSSTIAPKFI IDLLAKIKTI SLEGCLTQIF FFHFFGVAEI LLIVVMAYDC
YVAICKPLHY MNIISRQLCH LLVAGSWLGG FCHSIIQILV IIQLPFCGPN VIDHYFCDLQ
PLFKLACTDT FMEGVIVLAN SGLFSVFSFL ILVSSYIVIL VNLRNHSAEG RHKALSTCAS
HITVVILFFG PAIFLYMRPS STFTEDKLVA VFYTVITPML NPIIYTLRNA EVKIAIRRLW
SKKENPGRE
