OR4C5_HUMAN
ID OR4C5_HUMAN Reviewed; 326 AA.
AC Q8NGB2; Q6IFB2;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Olfactory receptor 4C5;
DE AltName: Full=Olfactory receptor OR11-99;
GN Name=OR4C5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04748.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C5";
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DR EMBL; AB065910; BAC06125.1; -; Genomic_DNA.
DR EMBL; BK004350; DAA04748.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS86201.1; -.
DR RefSeq; NP_001335152.1; NM_001348223.1.
DR AlphaFoldDB; Q8NGB2; -.
DR SMR; Q8NGB2; -.
DR STRING; 9606.ENSP00000321338; -.
DR GlyGen; Q8NGB2; 1 site.
DR BioMuta; OR4C5; -.
DR DMDM; 74760242; -.
DR PaxDb; Q8NGB2; -.
DR PeptideAtlas; Q8NGB2; -.
DR PRIDE; Q8NGB2; -.
DR ProteomicsDB; 73465; -.
DR Antibodypedia; 72043; 6 antibodies from 6 providers.
DR DNASU; 79346; -.
DR Ensembl; ENST00000319813.3; ENSP00000321338.3; ENSG00000176540.3.
DR GeneID; 79346; -.
DR KEGG; hsa:79346; -.
DR MANE-Select; ENST00000319813.3; ENSP00000321338.3; NM_001348223.2; NP_001335152.1.
DR UCSC; uc058bja.1; human.
DR CTD; 79346; -.
DR GeneCards; OR4C5; -.
DR HGNC; HGNC:14702; OR4C5.
DR HPA; ENSG00000176540; Not detected.
DR neXtProt; NX_Q8NGB2; -.
DR OpenTargets; ENSG00000176540; -.
DR VEuPathDB; HostDB:ENSG00000176540; -.
DR eggNOG; ENOG502T9JX; Eukaryota.
DR GeneTree; ENSGT00940000161803; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGB2; -.
DR OMA; MVTFPID; -.
DR OrthoDB; 968389at2759; -.
DR PhylomeDB; Q8NGB2; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NGB2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79346; 0 hits in 75 CRISPR screens.
DR GenomeRNAi; 79346; -.
DR Pharos; Q8NGB2; Tdark.
DR PRO; PR:Q8NGB2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGB2; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 4C5"
FT /id="PRO_0000150530"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..70
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..240
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 241..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 118..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 326 AA; 36862 MW; 18669FB8FB019166 CRC64;
MYVSNCNPCA IHRKINYPNT KLDFEQVNNI TEFILLGLTQ NAEAQKLLFA VFTLIYFLTM
VDNLIIVVTI TTSPALDSPV YFFLSFFSFI DGCSSSTMAP KMIFDLLTEK KTISFSGCMT
QLFVEHFFGG VEIILLVVMA YDCYVAICKP LYYLITMNRQ VCGLLVAMAW VGGFLHALIQ
MLLIVWLPFC GPNVIDHFIC DLFPLLKLSC TDTHVFGLFV AANSGLMCML IFSILITSYV
LILCSQRKAL STCAFHITVV VLFFVPCILV YLRPMITFPI DKAVSVFYTV VTPMLNPLIY
TLRNTEVKNA MKQLWSQIIW GNNLCD
